Regiões de estabilidade no ambiente de um sistema de asteroide triplo

This work was developed from the study by Araujo, R.A.N. et al. Stability regions around the components of the triple system 2001 SN263. (Monthly Notices Of The Royal Astronomical Society, 2012, v. 423(4), 3058-3073 p.) where it was studied the stable and unstable regions system (2001 SN263), which is a triple asteroid system, and these are celestial orbiting our sun. Being close to the Earth is characterized as NEA (Near-Earth Asteroids), asteroids and which periodically approach the Earth's orbit, given that there is great interest in the study and exploitation of these objects, it is the key can carry features that contribute to better understand the process of formation of our solar system. Study the dynamics of bodies that govern those systems proves to be greatly attractive because of the mutual gravitational perturbation of bodies and also by external disturbances. Recently, NEA 2001 SN263 was chosen as a target of Aster mission where a probe is sent for this triple system, appearing therefore the need for obtaining information for characterizing stable regions internal and external to the system, with respect to the effects of radiation pressure. First, this study demonstrated that the integrator used showed satisfactory results of the orbital evolution of bodies in accordance with previous studies and also the characterization of stable and unstable regions brought similar results to the study by Araujo et al. (2012). From these results it was possible to carry out the implementation of the radiation pressure in the system in 2001 SN263, in a region close to the central body, where the simulations were carried out, which brought as a result that the regions before being characterized as stable in unstable true for small particles size from 1 to 5 micrometers. So the next orbital region to the central body and the ... ( Complete abstract click electronic access below)

Estudo acelerado de estabilidade de hiclato de doxiciclina em comprimidos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise das perturbações de qualidade de energia em sistemas de distribuição e a adequação as tendências regulatórias do PRODIST

The public consultation n° 018/2014, for review the Module 8 of Procedures of Electricity Distribution (PRODIST), conducted by National Agency of Electric Energy (ANEEL), aims to improve the regulation of power quality, considering the phenomena harmonic distortion, voltage unbalance, voltage fluctuation and short term voltage variation. These regulatory changes impact in the way of analysis and treatment, of power quality disruption, by the electricity distribution. The developed work makes a study about the applications of these new regulatory requests and hopes to contribute with a better understanding. Through power quality measurements, in distribution substations, with different load profiles (industrial, urban and rural), was obtained a real view of the system, under the aspect of power quality, to evaluate the regulation adherence to the current version and proposed. In this case study, although being in accordance with the current methodology, happened a transgression of propose. With a comparative analysis, was possible to identify some phenomena that were more flexible in the proposed revision and others with more severe monitoring

Desenvolvimento e validação de método bioanalítico para quantificação de tiazolilhidrazona-9 (TZH-9) e determinação da estabilidade em plasma ex vivo

A doença de Chagas é uma doença parasitária causada pelo protozoário Trypanosoma cruzi (T. cruzi), que acomete o sistema digestivo e, principalmente, o cardíaco. É uma doença endêmica principalmente nos países da América Latina. A busca por novos fármacos para o tratamento dessa doença é de suma importância já que os existentes podem causar severos efeitos adversos e são efetivos somente na fase aguda. A molécula tiazolilhidrazona-9 (TZH-9) tem se destacado como uma excelente candidata a fármaco para tratamento da doença de Chagas e a continuidade de seu desenvolvimento deve envolver estudos de farmacocinética e metabolismo. Para a realização destes estudos é necessário o desenvolvimento e validação de um método bioanalítico para a determinação do composto em plasma, assim como avaliar a estabilidade do fármaco nesta matriz biológica com o intuito de verificar a ação de enzimas plasmáticas. Neste trabalho, foi desenvolvido e validado o método bioanalítico para quantificar o TZH-9 em plasma de ratos e humano que apresentou limites de confiança adequados. Também, avaliou-se a estabilidade do TZH-9 nessas matrizes biológicas, em plasma de ratos, o composto apresentou instabilidade após 2 horas na concentração inferior, sugerindo ação de enzimas plasmáticas no seu metabolismo; e em plasma de humanos, apresentou instabilidade após 15 minutos em ambas concentrações, sugerindo a susceptibilidade a ação das enzimas plasmáticas