Matemática e estatística aplicadas a gestão da qualidadade nos cursos de Engenharia de Produção no Brasil: um contraponto entre a formação e o mercado de trabalho

Pós-graduação em Educação Matemática - IGCE

Síntese e avaliação biológica de novos compostos das séries LAPDESF FUR-PQ E LAPDESF FUR-TS contra Trypanosoma cruzi

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da atividade antifúngica de peptídeos derivados da histatina-5 para o tratamento de candidose bucal

Os peptídeos têm sido amplamente estudados e demonstrados como uma estratégia promissora no combate a micro-organismos patogênicos, devido aos inovadores mecanismos de ação que apresentam e a menor indução de resistência nos microorganismos. Os peptídeos da família das Histatinas, naturalmente presentes na saliva humana, são os principais agentes que auxiliam na cicatrização e oclusão de feridas, re-epitelização e, além disso, dispõem de mecanismos de ação contra microorganismos, em especial, a Candida albicans. O agente etiológico da Candidiose bucal é a Candida albicans, um patógeno de origem fúngica, que acomete indivíduos de todas as idades, indivíduos imunologicamente debilitados e, especialmente, os usuários de próteses dentárias. Um importante fator de virulência da Candida albicans é a habilidade de formar biofilmes, estrutura comunitária microbiana revestida por exopolissacarídeos, capaz de aderir-se a superfícies lisas. Os biofilmes associam-se com a capacidade de causar infecções, com o desenvolvimento de resistência contra o sistema imune do hospedeiro e contra os antifúngicos. O uso indiscriminado e a exposição prolongada aos antifúngicos induz o surgimento de resistência a esses medicamentos, além disso existem cepas de Candida albicans resistentes ao tratamento com antifúngicos azólicos. Devido a isso surge a necessidade de desenvolvimento de novos alvos terapêuticos. O objetivo desse estudo consiste no desenvolvimento de análogos da Histatina-5 com algumas modificações estruturais, a fim de potencializar a ação terapêutica já comprovada dos peptídeos da família das Histatinas. A Histatina-5GH apresenta maior carga positiva que os demais peptídeos devido a troca de duas glicinas na estrutura da Histatina-5 por duas histidinas. Por sua vez, a Histatina-5SC possui o resíduo de serina C-terminal substituído por...

Avaliação das causas e consequências das patologias dos sistemas impermeabilizantes: um estudo de caso

This work aims to assess a case ofwaterproofing pathology, from the presentation of the pathological manifestations, thecharacterization and quantification of negotiationsproposals. With these data, graphs were elaborated with thepurpose ofemphasizing the cost increase from the time of intervention, to give an increase of 1,429.00 % inthe presented study. Also show the proportion of spending on finishes and waterproofing,demonstratingthe greatinfluence of the finishes in the composition of the treatment costs. Inthisstudy, it was foundthat these finishes made up89% of the total cost. In the bibliographic reference, presented to the active mechanisms, the characterization of waterproofing systems and the most common pathologies. It follows the importance of sealing to ensure integrity of a construction

Avaliação da atividade mutagênica de complexos heterolépticos de Rutênio(II) com atividade anti - Mycobacterium tuberculosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência da cultura organizacional na implementação de um programa de melhoria contínua de uma empresa de grande porte

The objective of this study was to identify the facilitators and restrictive factors promoted by the organizational culture on the implementation of a continuous improvement program in a company. The influence of organizational culture on tools used to improve processes and results demonstrate critical factors for international competitiveness, reflecting a company's strategy. Depending on how new working methods are implemented, organizational changes to reduce variation and waste, such as lean production, can affect the employee experience in the workplace and their learning conditions. Changes and formalization of the work process can be coercive, characterized by forced compliance, introduction of rules, and focus on technical and financial methods; or may be favorable, encouraging employee involvement in problem solving and stressing learning and innovation. The basis of the analysis lies with two models for assessing organizational culture - Denison Model and Competing Values Framework. The methodology used was: conducting interviews, a questionnaire, literature review and documentary analysis of a large company equipment industry. Results suggest that organizational culture plays an important role in the adoption of Lean practices. It can contribute to its effectiveness and job satisfaction, but it is not decisive feature of their success. The conclusion is that the organizational culture becomes a driving factor when aligned to the proposed practices and when taken into consideration for planning, acting as a limitation when it does not promote development and a participative environment

Avaliação da rigidez torcional do chassi de um protótipo Baja SAE através do método de elementos finitos e de ensaio experimental

The torsional stiffness of chassis is one of the most important properties of a vehicle's structure and therefore its measurement is important. For the first time, the torsional stiffness was considered on the design of a prototype Baja SAE of the team from UNESP - FEG, Equipe Piratas do Vale Bardahl. According to the team's opinion, the increase of stiffness on this prototype, called MB1114, made possible a great improvement in its performance during competitions. In this work, the experimental evaluation of the torsional stiffness from this prototype is performed, detailing the analysis of results, as well as, the hysteresis' effect, least-squares regression and uncertainty analysis. It also shows that it is possible to measure the torsional stiffness of chassis with a low experimental uncertainty without expending many resources. The test rig costed R$ 32,50 due the reuse of materials and the use of instrumentation already available on campus. Furthermore, it is simple to produce and can be easily stocked. Those features are important for Baja and Formula SAE teams. Lastly, the measured value is used to validate the finite element analysis performed by the team during this prototype's design, because similar studies will be performed for the new cars. After investigating the finite element analysis, one result 13,5% higher than the measured value was reached. This difference is believed to be occurred due the imperfections of the finite element model, in other words, for not been possible to simulate every phenomena present on the real model

Implementação de CADD nos cursos de graduação em engenharia mecânica

This study aims to demonstrate the importance of computer-aided design and drafting (CADD) software for mechanical engineers. In addition, evaluate the software: Inventor 2015, Creo 3.0 and Solid Edge ST8, developed by consolidate companies in the market. In order to accomplish those goals, software application and its advantages will be demonstrated for the industry and for the academia. The evaluation process consists in modeling two mechanical assemblies, in order to compare functional aspects among the software. At the end, it is concluded that the learning of CADD software is of great importance also is the basis for using Computer-aided Engineering (CAE) and Computer-Aided Manufacturing (CAM) tools. Furthermore, it is suggested that Inventor and Solid Edge are more likely to be used in the academia

Avaliação dos níveis de vibração no operador de um trator agrícola ensaiado em pista normatizada em diferentes velocidades de deslocamento

Pós-graduação em Agronomia (Energia na Agricultura) - FCA