Graph analysis of verbal fluency test discriminate between patients with Alzheimer’s disease, Mild Cognitive Impairment and normal elderly controls

Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the elderly, and different analytical methods are likely to extract even more information from the data generated in this test. Graph theory, a mathematical approach to analyze relations between items, represents a promising tool to understand a variety of neuropsychological states. This study reports a graph analysis of data generated by the semantic verbal fluency test by cognitively healthy elderly (NC), patients with Mild Cognitive Impairment – subtypes amnestic(aMCI) and amnestic multiple domain (a+mdMCI) - and patients with Alzheimer’s disease (AD). Sequences of words were represented as a speech graph in which every word corresponded to a node and temporal links between words were represented by directed edges. To characterize the structure of the data we calculated 13 speech graph attributes (SGAs). The individuals were compared when divided in three (NC – MCI – AD) and four (NC – aMCI – a+mdMCI – AD) groups. When the three groups were compared, significant differences were found in the standard measure of correct words produced, and three SGA: diameter, average shortest path, and network density. SGA sorted the elderly groups with good specificity and sensitivity. When the four groups were compared, the groups differed significantly in network density, except between the two MCI subtypes and NC and aMCI. The diameter of the network and the average shortest path were significantly different between the NC and AD, and between aMCI and AD. SGA sorted the elderly in their groups with good specificity and sensitivity, performing better than the standard score of the task. These findings provide support for a new methodological frame to assess the strength of semantic memory through the verbal fluency task, with potential to amplify the predictive power of this test. Graph analysis is likely to become clinically relevant in neurology and psychiatry, and may be particularly useful for the differential diagnosis of the elderly.

O profissional da informaçao e as habilidades exigidas no mercado de trabalho emergente

Diante de um novo perfil do emprego e do mercado de trabalho - que se transforma marcadamente em face das tecnologias de informação e comunicação (TIC) há uma demanda por profissionais munidos de novas habilidades e competências. Assim, objetiva-se, de modo geral, analisar as novas habilidades demandadas pelo mercado de trabalho atual para o profissional da informação. Para tanto, busca-se especificamente, caracterizar os fatores determinantes do contexto atual; verificar o impacto das TIC no mercado de trabalho do profissional da informação; e conhecer as transformações ocorridas no perfil deste profissional frente a estas mudanças. Para alcançar os objetivos propostos recorreu-se à pesquisa bibliográfica, bem como à análise de anúncios de empregos divulgados no website Catho On-line. A análise dos dados se deu de forma comparativa entre os anos de 2003 e 2005 e, permitiu concluir que as habilidades exigidas para o profissional da informação na atualidade dizem respeito, além dos conhecimentos técnicos, a fluência em idioma estrangeiro, ao domínio da informática, aos conhecimentos gerencias e, principalmente, às habilidades interpessoais_____________________________________________________________________________Facing a new profile of the job and the labor market - that changes remarkably regarding to the new technologies of information and communication (TIC), there is a demand for professionals who posses new abilities and competences. It was aimed at, then, in general, to analyze the new abilities disputed by the labor market for the professional of information, because of the new available resources. In order to do that, it was specifically searched, to characterize the decisive factors of the current context; to verify the impact of the TIC in the labor market of the professional of information; and to know the transformations happened in the profile of these professionals before these changes. To reach the proposed objectives it was realized bibliographical research, as well as to the analysis of advertisements of jobs published in the website Catho On-line, of comparative form between the years of 2003 and 2005. The analysis of the data allowed us to conclude that the abilities demanded for the professional of information at the present time concern, besides the technical knowledge, the fluency in a foreign language, to the domain of the computer science and the managing knowledge