Novas abordagens à visualização e interacção com dados turísticos

Com o forte crescimento tecnológico tem-se verificado, cada vez mais, o crescente aumento de Web sites, voltados para o contacto directo com o consumidor, onde é possível procurar, escolher e adquirir um determinado produto I serviço directamente ao fornecedor. As plataformas de suporte à pesquisa de produtos de turismo possibilitam a entrega de um grande volume de dados mediante a pesquisa efectuada. Esta informação é, na sua maior parte, informação textual e é geralmente disponibilizada ao utilizador (via uma página Web) sob a forma de uma listagem ou tabela. Este trabalho incide então sobre a proposta e implementação de um conjunto de interfaces com elevada ergonomia, que permitam uma interacção simples e intuitiva entre o utilizador e os dados de turismo, mais concretamente com reservas de aviação e hotel. Para este propósito foi desenvolvida uma Rich Internet Application que permite ao utilizador o ajuste de determinados factores, que influenciam estes produtos de turismo, de modo a encontrar com maior facilidade o que mais se enquadra nos seus gostos I objectivos no vasto conjunto de resultados da pesquisa. ABSTRACT; With the constant growth of information technology tools we have witnessed increase in the number of web Sites aimed to direct contact with the consumer, where users can search, select and purchase a product/service directly to the supplier. The platforms that support the search for tourism data enable the delivery of a large volume of data, as a result of the search that was done. This information is mostly textual and is, in general available to the user (via a web page) in a form of a large list or table. This work focuses on a proposal and implementation of a set of interfaces with high ergonomics. allowing a simple and intuitive interaction between the user and the tourism data, more specifically with air fares and hotels reservations. For this purpose was developed an Rich Internet Application that allows the user to adjust some factors that influence the tourism products, in order to more accurately find what fits their tastes objectives in the wide range of search results.

Rethinking Le Corbusier: Urban Design and History

It is generally assumed that Le Corbusier’s urban planning made a break with the past, and that the public spaces designed by him had nothing to do with anything that existed before – a conviction fostered by both the innovative character of his proposals and by the proliferation in his manifestos of watchwords that mask any evocation of the past – words like civilisation machiniste, l’esprit nouveau, l’architecture de demain. However, in his writings, Le Corbusier often mentioned the powerful analogy that exists between the architecture of other times and the logic of modern production. Vers une architecture, for example, contains a mixture of photographs showing silos, cars, aeroplanes, ships (i.e. the fruits of 19th and 20th century civil architecture and mechanical engineering) alongside photographs of Greek and Roman buildings. While Le Corbusier, at the end of the 1920s, claimed “I have only one teacher: the past; only one education: the study of the past”, a series of sketches in the first volume of the Œuvre complète, done during his youth at the archaeological sites visited during his Grand Tour, shows that his interest in the past went far beyond a simple reference.

Design, Synthesis and Bioassays of 3-substituted-3-hydroxyoxindoles for cholinesterase inhibition

Based on the positive bioassay results of the known oxindole hit compound rac-1-benzyl-3-hydroxy-3-phenylindolin-2-one which showed significant inhibition of butyrylcholinesterase (BuChE) (IC50=7.41 μM), a library of 31 analogues of 3-substituted-3-hydroxyoxindoles was synthesized and screened for both acetylcholinesterase (AChE) and BuChE activity. Our bioassays revealed that some of the new compounds exhibited moderate inhibition of eel AChE (EeAChE) and very good inhibition of equine serum BuChE (EqBuChE) with a best IC50 of 1.02 μM. On the basis of these results, the lead compound 1-((1-benzylpiperidin-4-yl)methyl)-3-hydroxy-3-phenylindolin-2-one was designed, which was shown to interact well with the enzymes active sites by molecular docking, was synthesized and upon bioassay gave an IC50 of 6.61 μM for BuChE. Interestingly, when we separated rac-benzyl-3-hydroxy-3-phenylindolin-2-one into the individual enantiomers (R)- and (S)-benzyl-3-hydroxy-3-phenylindolin-2-one it was the latter enantiomer that gave the best IC50 of 6.19 μM for BuChE.