2 resultados para Potential antichagasic agents

em Repositório Científico da Universidade de Évora - Portugal


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A presente proposta de investigação, ao abordar os dilemas inerentes à cooperação transfronteiriça, no âmbito da educação/formação, no Alentejo-Extremadura, traduz-se assim, num diagnóstico a nível meso, já que aborda em termos micro, o papel dos professores das Escolas Oficiais de Idiomas da Extremadura enquanto potenciais agentes de regulação da cooperação transfronteiriça, através das suas relações interpessoais, funcionando esta regulação como uma ponte ou forma intermediária de atingir a regulação macro, entendida aqui como a regulação nacional e internacional, no panorama transfronteiriço Portugal/Espanha. A Escola Oficial de Idiomas, ao possuir uma estrutura organizacional geradora de uma dinâmica das relações sociais dos actores, permitiu diagnosticar, no seu dinamismo, a importância das interdependências entre os indivíduos, e destes com o exterior, as quais poderão constituir "redes emergentes'' de cooperação, assentes essencialmente em relações débeis e muitas informais, servindo de eventuais nós na criação de redes de cooperação transfronteiriça mais formais. / Summary: This research proposal, as it tackles the dilemmas inherent in cross-border cooperation concerning education/training in Alentejo-Extremadura, is thus a meso level analysis, since it deals, at the micro levei, with the role of the teachers in the Official Language Schools of Extremadura as potential regulation agents of cross-border cooperation, through their interpersonal relationships. This regulation acts as a bridge or an intermediary way of achieving macro regulation, which refers to the national and international regulation in Portugal/Spain's cross-border context. The Official Language School, possessing an organizational structure that brings dynamics into the actors’ social relations, has made it possible, within its dynamism, to establish the importance of the interdependence between individuals, and between them and the outside, which may create "emerging networks" of cooperation, based mostly in feeble and many informal relationships, operating as possible ties in the creation of more formal networks of cross-border cooperation.

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Several biosurfactants with antagonistic activity are produced by a variety of microorganisms. Lipopeptides (LPPs) produced by some Bacillus strains, including surfactin, fengycin and iturin are synthesized nonribosomally by mega-peptide synthetase (NRPS) units and they are particularly relevant as antifungal agents. Characterisation, identification and evaluation of the potentials of several bacterial isolates were undertaken in order to establish the production of active lipopeptides against biodeteriogenic fungi from heritage assets. Analysis of the iturin operon revealed four open reading frames (ORFs) with the structural organisation of the peptide synthetases. Therefore, this work adopted a molecular procedure to access antifungal potential of LPP production by Bacillus strains in order to exploit the bioactive compounds synthesis as a green natural approach to be applied in biodegraded cultural heritage context. The results reveal that the bacterial strains with higher antifungal potential exhibit the same morphological and biochemical characteristics, belonging to the genera Bacillus. On the other hand, the higher iturinic genetic expression, for Bacillus sp. 3 and Bacillus sp. 4, is in accordance with the culture antifungal spectra. Accordingly, the adopted methodology combining antifungal screening and molecular data is represent a valuable tool for quick identification of iturin-producing strains, constituting an effective approach for confirming the selection of lipopeptides producer strains.