Do comunismo à União Europeia: 20 anos que mudaram a história política e económica da Bulgária: Uma abordagem pela teoria e prática da condicionalidade

O mecanismo da condicionalidade pode ser considerado como um dos sucessos da UE na avaliação da forma como este afectou os processos de transição nos países pós-comunistas, em particular no caso dos países envolvidos no Quinto Alargamento. Este trabalho avalia a importância do mecanismo da condicionalidade na região da Europa de Leste, buscando analisar as políticas da UE em relação à Bulgária no período de 20 anos de difícil transição de um sistema comunista planificado para uma economia de mercado. Avaliamos também as políticas europeias de pré-adesão e as condições de adesão. Além disso, prestamos ainda atenção ao fenómeno do mecanismo da condicionalidade específico da UE, como tal, comparamos o seu impacto com os mecanismos do FMI e do Banco Mundial. Concluímos com a tentativa de fornecer alguns elementos sobre a utilidade prática do mecanismo de condicionalidade no Sudeste da Europa, definindo as suas principais realizações, bem como os problemas enfrentados. Através de uma revisão da literatura disponível, e adoptando uma perspectiva histórica, procuramos avaliar também as novas responsabilidades que a Bulgária assumiu ao alargar a fronteira exterior da UE e as consequências que daí decorreram para as relações políticas e económicas com os países vizinhos. /ABSTRACT: The conditionality mechanism can be considered one of the successes of the EU when estimated its influence over the transition process in the post-communist countries, especially for the countries involved in the Fifth Enlargement. This study evaluates the significance of the mechanism of conditionality in the region of Eastern Europe, analyzing the policies of the EU for Bulgaria during the 20 years of difficult transition from a planned communist system to a market economy. The European policies of pre-accession and the accession conditions are evaluated. Also, it pays attention to the phenomenon of the conditionality mechanism specific for EU, comparing its impact with the mechanisms of the IMF and World Bank. And concludes with an attempt to provide some elements about how useful has been the conditionality mechanism in South East Europe, defining the main achievements and difficulties that it faces. Having a look at the available literature and also reviewing it from historical point of view, it's evaluated the new responsibilities that Bulgaria assumed after extending the external frontiers of EU and the consequences for the political and economic relations with neighbor countries.

Transcriptomic analysis of genes involved in the lipid metabolism of the Alentejano pig

The Alentejano pig is an autochthonous breed scarcely selected, that due to its high trend for fat deposition present poorer meat yields than modern commercial breeds. However, its higher contents of intramuscular fat (IMF) increase pork sensory attributes and consumers’ acceptability. Animal cells can obtain fatty acids (FA) from three distinct pathways: diet ingested fats, lipolysis of stored lipids in cells and through de novo synthesis. Betaine has been used as a dietary supplement in pig nutrition to reduce fat deposition and increase lean muscle mass with inconsistent results so far. This study compares the expression of genes involved in lipid metabolism from pigs consuming a control diet, and the control diet supplemented with betaine (WB). The expression of two genes involved in lipogenesis and lipolysis were evaluated in L. lumborum and B. femoris: ACC, which mediates the carboxylation of acetyl CoA into malonyl CoA concluding the first step of de novo synthesis, and MCPT1 which is responsible for the transport of acyl groups into the mitochondria for the start of β-oxidation.

Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed

This study evaluates the effects of betaine supplementation (1 g kg−1 for 20 weeks) on the regulation of genes involved in lipid and cholesterol metabolism of Longissimus lumborum and Biceps femoris from obese Alentejano pigs. Betaine supplementation led to an increase in total cholesterol in both muscles, complementing results previously published indicating a significant increase on the intramuscular lipid content. The expression of twelve genes involved in lipogenesis, lipolysis/FA oxidation, FA transport, and cholesterol metabolism, as well as two transcription factors were also evaluated. Genes related to lipid and cholesterol synthesis plus FA transport were consistently up-regulated in both muscles of betaine fed pigs. On the other hand, genes related to lipolysis/FA oxidation were not affected or down-regulated by betaine supplementation. Our data suggest that the underlying mechanism regulating IMF and cholesterol accumulation in Alentejano pigs supplemented with betaine is associated with the up-regulation of genes involved in lipid synthesis, FA transport, and cholesterol synthesis.