“Biomarkers in a One Health perspective: current knowledge of their ability to merge human and animal health

Biomarkers are nowadays essential tools to be one step ahead for fighting disease, enabling an enhanced focus on disease prevention and on the probability of its occurrence. Research in a multidisciplinary approach has been an important step towards the repeated discovery of new biomarkers. Biomarkers are defined as biochemical measurable indicators of the presence of disease or as indicators for monitoring disease progression. Currently, biomarkers have been used in several domains such as oncology, neurology, cardiovascular, inflammatory and respiratory disease, and several endocrinopathies. Bridging biomarkers in a One Health perspective has been proven useful in almost all of these domains. In oncology, humans and animals are found to be subject to the same environmental and genetic predisposing factors: examples include the existence of mutations in BR-CA1 gene predisposing to breast cancer, both in human and dogs, with increased prevalence in certain dog breeds and human ethnic groups. Also, breast feeding frequency and duration has been related to a decreased risk of breast cancer in women and bitches. When it comes to infectious diseases, this parallelism is prone to be even more important, for as much as 75% of all emerging diseases are believed to be zoonotic. Examples of successful use of biomarkers have been found in several zoonotic diseases such as Ebola, dengue, leptospirosis or West Nile virus infections. Acute Phase Proteins (APPs) have been used for quite some time as biomarkers of inflammatory conditions. These have been used in human health but also in the veterinary field such as in mastitis evaluation and PRRS (porcine respiratory and reproductive syndrome) diagnosis. Advantages rely on the fact that these biomarkers can be much easier to assess than other conventional disease diagnostic approaches (example: measured in easy to collect saliva samples). Another domain in which biomarkers have been essential is food safety: the possibility to measure exposure to chemical contaminants or other biohazards present in the food chain, which are sometimes analytical challenges due to their low bioavailability in body fluids, is nowadays a major breakthrough. Finally, biomarkers are considered the key to provide more personalized therapies, with more efficient outcomes and fewer side effects. This approach is expected to be the correct path to follow also in veterinary medicine, in the near future.

O apoio pedagógico e educacional a crianças e jovens hospitalizados: A escola nos hospitais

O presente estudo teve como objectivo, partindo de uma análise comparativa entre dois hospitais, descrever e identificar aspectos que pudessem comprovar que as actividades escolares desenvolvidas no contexto hospitalar podem contribuir para amenizar o sofrimento de crianças hospitalizadas assim como contribuem para o seu desenvolvimento integral. As bases de assistência à criança hospitalizada têm vindo a modificar-se nas últimas décadas derivado aos resultados de pesquisas nas áreas das ciências médicas, humanas e sociais. Tendo estas concepções como base, criam-se então, perspectivas de como apoiar melhor a criança no processo de hospitalização que tem de enfrentar, esclarecendo e auxiliando também os profissionais que têm como objectivo primordial o bem-estar da criança, a todos os níveis: físico, pedagógico, social, afectivo e psicológico. A inserção da escola nos hospitais, adequada às necessidades e situação de cada criança, recupera a socialização desta por um processo de inclusão, dando continuidade à sua escolarização e valorizando as suas novas aprendizagens. Para a realização desta investigação, muito contaram as participações, tanto do Instituto de Português de Oncologia de Lisboa, como do Hospital do Espírito Santo de Évora, EPE, que me deram acesso aos seus respectivos serviços de Pediatria, assim como permitiram o meu contacto com todos os actores envolvidos. Foi realizada uma análise qualitativa tanto da recolha bibliográfica como das comunicações recolhidas através das entrevistas realizadas e das observações efectuadas nos contextos de pesquisa. Obtive consideráveis informações que me permitiram ratificar a considerável importância e eficácia das actividades pedagógicas e educacionais no desenvolvimento da criança em situação de hospitalização, permitindo assim também amenizar esta fase menos boa da vida destas crianças. ABSTRACT; This study aims to, by way of a comparative analysis between two hospitais, describe and identify aspects that are able to prove that the school activities developed in hospitals can help to ease the suffering of hospitalized children as well as contribute to their full development. Over the last decades, the type of support given to hospitalized children has been changing due to the influence of studies conducted in the medical, human and social sciences fields. With these conceptions as a basis, perspectives have been created regarding how to provide better support to children during their stay at the hospital, clarifying and helping the professionals whose fundamental goal is the child's welfare at all levels: physical, pedagogical, social, emotional and psychological. Within the hospital walls, a classroom suited to the needs and situation of each child greatly benefits their socialization recovery through a process of inclusion, thereby permitting a continuation of the learning process. ln carrying out this research, the participation of the Portuguese Institute of Oncology and of the Évora Hospital was essential, wherein I was granted access to their pediatric services and to all the persons involved in this context. A qualitative analysis was conducted using data extracted from bibliographic research as well as from speeches gathered during interviews performed within the research framework. The substantial amount of information allows me to ratify the considerable importance and success of the pedagogic and educational activities in the development of hospitalized children, allowing, as was said before, to ease this difficult stage of children’s.