Clínica médica e cirúrgica em animais de companhia

O presente relatório foi realizado no âmbito do Mestrado Integrado de Medicina Veteri-nária, estando divido em duas partes. A primeira parte refere-se à casuística acompanhada ao longo do estágio curricular, realizado no Centro Hospitalar Veterinário do Porto, no período de-corrido entre 1 de setembro de 2015 e 29 de fevereiro de 2016. A segunda parte engloba uma monografia sobre o tema “Cetoacidose Diabética em canídeos”, incluindo ainda o relato de três casos clínicos acompanhados no decorrer do estágio. A cetoacidose diabética (CAD) é uma complicação urgente do diabetes mellitus, ocorrendo principalmente em animais nunca antes tratados com insulina de longa ação. O diagnóstico de CAD passa pela anamnese, sinais clínicos e deteção de hiperglicemia severa, glicosúria e cetonúria. O diagnóstico e tratamento de doenças concomitantes constituem o passo mais desafiante. O prognóstico depende da severidade da acidose, das doenças concomitantes e das limitações financeiras dos proprietários; Abstract: Small Animal Practice This report was carried out for the completion of the Master degree in veterinary medicine and is divided in two parts. The first part includes the accompanied cases throughout the train-eeship, which was held at the Centro Hospitalar Veterinário of Porto, between September 1st 2015 and February 29th 2016. The second part includes a monograph on "Diabetic Ketoacidosis in dogs ", including the report of three clinical cases followed during the internship. Diabetic ke-toacidosis (DKA) is an urgent complication of diabetes mellitus, occurring mainly in animals that were never treated with long-action insulin. The diagnosis of DKA involves the history, clinical signs and detection of severe hyperglycemia, glycosuria and ketonuria. The diagnosis and treat-ment of concomitant diseases are the most challenging steps. The prognosis depends on the severity of acidosis and concomitant diseases, as well as the financial restrictions of the owners.

Metformin adsorption onto activated carbons prepared by hydrothermal carbonization and activation

The hydrothermal carbonization can be considered an environmental friendly process for the production of carbon materials with tailored properties, such as regular porous structure and specific surface chemistry. This process is easy to perform and uses mild temperatures without the use of solvents or gases, which results in a positive environmental balance when compared with the usual pyrolysis process [1]. Diabetes affects more than 152 million people in Europe and is on the rise all over the World. Metformin is one of the most used drugs to treat type 2 diabetes. This drug is an endocrine disruptor with a potential negative impact in the environment due to the fact that metformin is almost not metabolized in the human body and the incorrect disposal into the domestic garbage. Another relevant aspect is the danger of overdose intake of the drug that can lead to lactic acidosis, which in extreme cases can be lethal. The work now reported study the in vitro adsorption of metformin onto activated carbons using simulated gastric and intestinal fluids.