1 resultado para Soto, Hernando de, ca. 1500-1542.
em Nottingham eTheses
Filtro por publicador
- Rhode Island School of Design (8)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (6)
- Adam Mickiewicz University Repository (8)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (3)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (6)
- Aquatic Commons (16)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (10)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (4)
- Biblioteca Digital da Câmara dos Deputados (3)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (14)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (19)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Biblioteca Digital Loyola - Universidad de Deusto (6)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (79)
- Brock University, Canada (22)
- Bucknell University Digital Commons - Pensilvania - USA (4)
- CaltechTHESIS (3)
- Cámara de Comercio de Bogotá, Colombia (1)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (28)
- Center for Jewish History Digital Collections (8)
- Chapman University Digital Commons - CA - USA (12)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (158)
- Cochin University of Science & Technology (CUSAT), India (6)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (14)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- Digital Peer Publishing (2)
- Diposit Digital de la UB - Universidade de Barcelona (2)
- Dokumentenserver der Akademie der Wissenschaften zu Göttingen (1)
- Duke University (2)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- FAUBA DIGITAL: Repositorio institucional científico y académico de la Facultad de Agronomia de la Universidad de Buenos Aires (2)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (22)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (5)
- Indian Institute of Science - Bangalore - Índia (67)
- Instituto Politécnico do Porto, Portugal (1)
- Livre Saber - Repositório Digital de Materiais Didáticos - SEaD-UFSCar (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (4)
- Martin Luther Universitat Halle Wittenberg, Germany (1)
- Massachusetts Institute of Technology (1)
- Ministerio de Cultura, Spain (41)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (9)
- Publishing Network for Geoscientific & Environmental Data (12)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (84)
- Queensland University of Technology - ePrints Archive (39)
- RDBU - Repositório Digital da Biblioteca da Unisinos (2)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Aberto da Universidade Aberta de Portugal (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- REPOSITORIO DIGITAL IMARPE - INSTITUTO DEL MAR DEL PERÚ, Peru (1)
- Repositorio Institucional da UFLA (RIUFLA) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (107)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- School of Medicine, Washington University, United States (1)
- Universidad Autónoma de Nuevo León, Mexico (16)
- Universidad del Rosario, Colombia (31)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universidade Metodista de São Paulo (1)
- Universitat de Girona, Spain (20)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (1)
- Université de Montréal, Canada (3)
- University of Michigan (31)
- University of Queensland eSpace - Australia (1)
- WestminsterResearch - UK (1)
Resumo:
We investigate key characteristics of Ca⁺ puffs in deterministic and stochastic frameworks that all incorporate the cellular morphology of IP[subscript]3 receptor channel clusters. In a first step, we numerically study Ca⁺ liberation in a three dimensional representation of a cluster environment with reaction-diffusion dynamics in both the cytosol and the lumen. These simulations reveal that Ca⁺ concentrations at a releasing cluster range from 80 µM to 170 µM and equilibrate almost instantaneously on the time scale of the release duration. These highly elevated Ca⁺ concentrations eliminate Ca⁺ oscillations in a deterministic model of an IP[subscript]3R channel cluster at physiological parameter values as revealed by a linear stability analysis. The reason lies in the saturation of all feedback processes in the IP[subscript]3R gating dynamics, so that only fluctuations can restore experimentally observed Ca⁺ oscillations. In this spirit, we derive master equations that allow us to analytically quantify the onset of Ca⁺ puffs and hence the stochastic time scale of intracellular Ca⁺ dynamics. Moving up the spatial scale, we suggest to formulate cellular dynamics in terms of waiting time distribution functions. This approach prevents the state space explosion that is typical for the description of cellular dynamics based on channel states and still contains information on molecular fluctuations. We illustrate this method by studying global Ca⁺ oscillations.