1 resultado para Presynaptic Terminals
em Nottingham eTheses
Filtro por publicador
- Repository Napier (3)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (13)
- Archive of European Integration (2)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (33)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (6)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (14)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (4)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (26)
- Brock University, Canada (7)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (5)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (21)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (17)
- Cochin University of Science & Technology (CUSAT), India (7)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (6)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (12)
- Digital Commons - Michigan Tech (2)
- Digital Commons @ DU | University of Denver Research (2)
- Digital Commons at Florida International University (1)
- Digital Peer Publishing (6)
- DigitalCommons@The Texas Medical Center (28)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (3)
- Greenwich Academic Literature Archive - UK (3)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (7)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (40)
- Instituto Politécnico do Porto, Portugal (1)
- Massachusetts Institute of Technology (3)
- National Center for Biotechnology Information - NCBI (132)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (33)
- Queensland University of Technology - ePrints Archive (55)
- RDBU - Repositório Digital da Biblioteca da Unisinos (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (7)
- Repositório digital da Fundação Getúlio Vargas - FGV (4)
- Repositório Institucional da Universidade de Aveiro - Portugal (4)
- Repositório Institucional da Universidade de Brasília (3)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (73)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (9)
- SerWisS - Server für Wissenschaftliche Schriften der Fachhochschule Hannover (1)
- Universidad de Alicante (11)
- Universidad del Rosario, Colombia (8)
- Universidad Politécnica de Madrid (36)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (10)
- Universidade Federal do Rio Grande do Norte (UFRN) (14)
- Universidade Metodista de São Paulo (1)
- Universitat de Girona, Spain (4)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (4)
- Université de Montréal (1)
- Université de Montréal, Canada (22)
- University of Michigan (44)
- University of Queensland eSpace - Australia (28)
- University of Washington (3)
- WestminsterResearch - UK (2)
Resumo:
Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects. Auditory gating is perturbed in schizophrenic patients and pharmacologically by drugs such as amphetamine, phencyclidine or ketamine, which precipitate schizophrenic-like symptoms in normal subjects. The neurobiological basis underlying this sensory gating can be investigated using local field potential recordings from single electrodes. In this paper we use such technology to investigate the role of cannabinoids in sensory gating. Cannabinoids represent a fundamentally new class of retrograde messengers which are released postsynaptically and bind to presynaptic receptors. In this way they allow fine-tuning of neuronal response, and in particular can lead to so-called depolarization-induced suppression of inhibition (DSI). Our experimental results show that application of the exogenous cannabinoid WIN55, 212-2 can abolish sensory gating as measured by the amplitude of local field responses in rat hippocampal region CA3. Importantly we develop a simple firing rate population model of CA3 and show that gating is heavily dependent upon the presence of a slow inhibitory (GABAB) pathway. Moreover, a simple phenomenological model of cannabinoid dynamics underlying DSI is shown to abolish gating in a manner consistent with our experimental findings.