Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer

In embracing a multidisciplinary approach to the management of patients with sentinel node biopsy in breast cancer, the pathologist task is to screen sentinel nodes for possible metastasis. The consequences of missing sentinel node micrometastasis can directly influence treatment strategies, and this screening therefore has to be performed with more attention than usual. There is presently great diversity in the histopathological work-up of sentinel nodes, with many centres employing additional techniques such as immunohistochemistry, reverse transcription polymerase chain reaction or flow cytometry in addition to routine haematoxylin and eosin staining. In this review, we address the pathological validation and significance of micrometastasis in sentinel node biopsy in primary breast cancer

Discontinuous Galerkin Computation of the Maxwell Eigenvalues on Simplicial Meshes

This paper is concerned with the discontinuous Galerkin approximation of the Maxwell eigenproblem. After reviewing the theory developed in [5], we present a set of numerical experiments which both validate the theory, and provide further insight regarding the practical performance of discontinuous Galerkin methods, particularly in the case when non-conforming meshes, characterized by the presence of hanging nodes, are employed.

Experience with the use of Acrobat in the CAJUN publishing project

Adobe's Acrobat software, released in June 1993, is based around a new Portable Document Format (PDF) which offers the possibility of being able to view and exchange electronic documents, independent of the originating software, across a wide variety of supported hardware platforms (PC, Macintosh, Sun UNIX etc.). The fact that Acrobat's imageable objects are rendered with full use of Level 2 PostScript means that the most demanding requirements can be met in terms of high-quality typography and device-independent colour. These qualities will be very desirable components in future multimedia and hypermedia systems. The current capabilities of Acrobat and PDF are described; in particular the presence of hypertext links, bookmarks, and yellow sticker annotations (in release 1.0) together with article threads and multi-media plugins in version 2.0, This article also describes the CAJUN project (CD-ROM Acrobat Journals Using Networks) which has been investigating the automated placement of PDF hypertextual features from various front-end text processing systems. CAJUN has also been experimenting with the dissemination of PDF over e-mail, via World Wide Web and on CDROM.