Cerebrovascular dysfunction in the presence of chronic inflammation

Background: Patients with autoimmune disease have increased incidence of stroke. Hemorrhagic stroke (HS) is associated with loss of cerebrovascular function, leading to micro-vessel burst, and hemorrhage. We believe chronic inflammation is involved in loss of cerebrovascular function and HS. We established a hypertensive-arthritis model in spontaneously hypertensive rats (SHR) fed either standard rodent diet (0.59% NaCl) (RD) or high salt diet (4% NaCl) (HSD) and compared them to non-inflamed SHR. Methods: Complete Freund’s adjuvant (CFA) was injected into the left paw to induce mono-arthritis. Blood pressure and inflammation was monitored. At endpoint, animals were sacrificed and evaluated for HS while middle cerebral artery (MCA) was isolated for functional studies. Results: HS was observed in 90% of CFA-treated groups. The MCA of arthritic RD-SHR exhibited decreased ability to undergo pressure dependent constriction (PDC). All HSD-SHR showed a decreased response to PDC. However, arthritic HSD-SHR also demonstrated a diminished response to vasoactive peptides. Conclusion: HS occurring with CFA injection corresponds with loss of MCA function. Chronic HSD appears to further exacerbate vascular dysfunction in the MCA.

Exploring the Role of Parental Hearsay when Children Witness a Crime

In cases of potential child abuse, parents may provide hearsay testimony on behalf of a child, retelling events from the child’s perspective. However, according to the limited research that exists, parents may have a negative impact on their child’s memory of an event (Principe, DiPuppo, & Gammel, 2013). In order to gain a better understanding of parental hearsay, parents’ descriptions of information children provided in recorded parent-child discussions were compared to the actual information the children provided in the initial discussion and in a 1-week follow-up interview. Children interviewed by parents were also compared to children interviewed by a trained interviewer. To date, 11 children between the ages of 6-9 years have been assessed. While the current sample size was too small to yield many significant results, graphs and effect sizes suggest there are differences in memory accuracy and completeness between parents and children and across children’s interview condition. Whether hearsay testimony or children’s testimony is preferable may depend on how suggestive the initial parent-child discussion is.