5 resultados para big-box retailing
em Universidade do Minho
Resumo:
(Excerto) Poder-se-á dizer que há uma informação televisiva “pré” e “pós” “Big Brother”? Detendo-nos nos programas de informação não-diária dos canais generalistas portugueses, procuraremos perceber de que forma o horário nobre, nomeadamente dos canais privados, se esvaziou desse tipo de programação. Esta é uma pequena parte de uma investigação que estamos a desenvolver no projecto de doutoramento e, por outro lado, integra-se num trabalho do grupo Mediascópio que recentemente analisou casos que, no início deste século, alteraram o modo de encarar/fazer jornalismo. Tendo aqui como referência os anos de 1999 (altura em que ainda não estavam no ar as chamadas “novelas da vida real”) e de 2003 (ano após o qual todos os canais generalistas já tinham emitido esse tipo de programas), procederemos a uma análise da informação não-diária no segmento do “prime time”, salientando as tendências do jornalismo televisivo que, nos últimos anos, se vem desenhando no pequeno ecrã.
Numerical Assessment of the out-of-plane response of a brick masonry structure without box behaviour
Resumo:
This paper presents the assessment of the out-of-plane response due to seismic loading of a masonry structure without rigid diaphragm. This structure corresponds to real scale brick masonry specimen with a main façade connected to two return walls. Two modelling approaches were defined for this evaluation. The first one consisted on macro modelling, whereas the second one on simplified micro modelling. As a first step of this study, static nonlinear analyses were conducted to the macro model aiming at evaluating the out-of-plane response and failure mechanism of the masonry structure. A sensibility analyses was performed in order to assess the mesh size and material model dependency. In addition, the macro models were subjected to dynamic nonlinear analyses with time integration in order to assess the collapse mechanism. Finally, these analyses were also applied to a simplified micro model of the masonry structure. Furthermore, these results were compared to experimental response from shaking table tests. It was observed that these numerical techniques simulate correctly the in-plane behaviour of masonry structures. However, the
Resumo:
Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.
Resumo:
Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação
Resumo:
Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação