Crescer com valores é valorizar-se

Relatório de estágio de mestrado em Educação Pré-escolar

A perceção dos alunos sobre a Educação Física à entrada do ensino secundário: um estudo comparativo entre o ensino regular e profissional

Relatório de estágio de mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário

Monitoring energy consumption in android applications

Dissertação de Mestrado em Engenharia Informática

Spectrum-based energy leak localization

Dissertação de Mestrado em Engenharia Informática

Categorização do consumo de energia em sistemas de povoamento de Data Warehouses

Os recursos computacionais exigidos durante o processamento de grandes volumes de dados durante um processo de povoamento de um data warehouse faz com que a necessidade da procura de novas implementações tenha também em atenção a eficiência energética dos diversos componentes processuais que integram um qualquer sistema de povoamento. A lacuna de técnicas ou metodologias para categorizar e avaliar o consumo de energia em sistemas de povoamento de data warehouses é claramente notória. O acesso a esse tipo de informação possibilitaria a construção de sistemas de povoamento de data warehouses com níveis de consumo de energia mais baixos e, portanto, mais eficientes. Partindo da adaptação de técnicas aplicadas a sistemas de gestão de base de dados para a obtenção dos consumos energéticos da execução de interrogações, desenhámos e implementámos uma nova técnica que nos permite obter os consumos de energia para um qualquer processo de povoamento de um data warehouse, através da avaliação do consumo de cada um dos componentes utilizados na sua implementação utilizando uma ferramenta convencional. Neste artigo apresentamos a forma como fazemos tal avaliação, utilizando na demonstração da viabilidade da nossa proposta um processo de povoamento bastante típico em data warehouses – substituição encadeada de chaves operacionais -, que foi implementado através da ferramenta Kettle.

Enteroscopia por cápsula e doença de Crohn: Caminhos para a otimização

Tese de Doutoramento em Medicina

Analysis and selection of indicators for a sustainability assessment method for school buildings based on SBTool ‐ PT

Nowadays, the sustainability of buildings has an extreme importance. This concept goes towards the European aims of the Program Horizon 2020, which concerns about the reduction of the environmental impacts through such aspects as the energy efficiency and renewable technologies, among others. Sustainability is an extremely broad concept but, in this work, it is intended to include the concept of sustainability in buildings. Within the concept that aims the integration of environmental, social and economic levels towards the preservation of the planet and the integrity of the users, there are, currently, several types of tools of environmental certification that are applicable to the construction industry (LEED, BREEAM, DGNB, SBTool, among others). Within this context, it is highlighted the tool SBTool (Sustainable Building Tool) that is employed in several countries and can be subject to review in institutions of basic education, which are the base for the formation of the critical masses and for the development of a country. The main aim of this research is to select indicators that can be used in a methodology for sustainability assessment (SBTool) of school buildings in Portugal and in Brazil. In order to achieve it, it will also be analyzed other methodologies that already incorporate parameters directly related with the schools environment, such as BREEAM or LEED.

The importance of the category of consciousness and education for sustainability in methodologies for eco‐efficiency in school buildings

This document reports the importance of the category of consciousness and education for sustainability in the school environment. Education in school has a potential to make the benefits of the building construction visible for society and media, showing to the students, parents and communities how sustainability in built environment could improve the people life in economic, social and environment aspects. Thus, this paper addresses the main events related to sustainability, such as the Stockholm Conference, the Brundtland report, United Nations Conference on Environment and Development (UNCED) and Agenda 21, until reaching the necessity of the elaboration of Methodologies for environmental assessment of building, and later, the development of the specific methodologies according to the buildings. It is also described some examples of sustainability in schools in Germany, Finland and Italy and what kind of sustainable systems those countries are currently using.

Produção científica da Universidade do Minho indexada na Web of Science e Scopus 2009-2013

Este relatório segue a metodologia utilizada no estudo da produção científica da Universidade do Minho do quinquénio 2008-2012. No estudo da produção de 2009-2013, para além da análise dos dados indexados na Web of Science, optou-se por acrescentar a análise dos dados indexados na Scopus, procedendo-se à comparação dos resultados entre ambas as bases de dados sempre que adequado e possível.

Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of non-B and -G Subtypes

Existing data supports Portugal as the Western Europe country with highest HIV-1 subtype diversity. However, detailed phylogenetic studies of Portuguese HIV-1 epidemics are still scarce. Thus, our main goal was to analyze the phylodynamics of a local HIV-1 infection in the Portuguese region of Minho. Molecular epidemiological analysis was applied to data from 289 HIV-1 infected individuals followed in the reference Hospital of the province of Minho, Portugal, in which isolated viruses had been sequenced between 2000 and 2012. Viruses of the G (29.1%) and B (27.0%) subtypes were the most frequent, followed by recombinant forms (17.6%), C (14.5%), F1 (7.3%) and A1 (4.2%) subtypes. Multinomial logistic regression revealed that the odds of being infected with A1 and F1 subtype increased over the years when compared with B, G, C or recombinant viruses. As expected, polyphyletic patterns suggesting multiple and old introductions of subtypes B and G were found. However, transmission clusters of non-B and -G viruses among native individuals were also found with the dates of the most recent common ancestor estimated to the early 2000s. Our study supports that the HIV-1 subtype diversity in the Portuguese region of Minho is high and has been increasing in a manner that is apparently driven by factors other than immigration and international travel. Infections with A1 and F1 viruses in the region of Minho are becoming established and were mainly found in sexually transmitted clusters, reinforcing the need for more efficacious control measures targeting this infection route.

Myeloid Sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control

Sirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several transcription factors and enzymes. Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria monocytogenes infection. The impact of this molecule in the context of chronic infections remains unknown. We found that specific Sirt2 deletion in the myeloid lineage transiently increased Mycobacterium tuberculosis load in the lungs and liver of conditional mice. Sirt2 did not affect long-term infection since no significant differences were observed in the bacterial burden at days 60 and 120 post-infection. The initial increase in M. tuberculosis growth was not due to differences in inflammatory cell infiltrates in the lung, myeloid or CD4+ T cells. The transcription levels of IFN-?, IL-17, TNF, IL-6 and NOS2 were also not affected in the lungs by Sirt2-myeloid specific deletion. Overall, our results demonstrate that Sirt2 expression has a transitory effect in M. tuberculosis infection. Thus, modulation of Sirt2 activity in vivo is not expected to affect chronic infection with M. tuberculosis.

IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages

The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL-17 inhibits p53, and impacts on the intrinsic apoptotic pathway, by increasing the Bcl2 and decreasing Bax expression, decreasing cytochrome c release from the mitochondria, and inhibiting caspase-3 activation. The same effect of IL-17 was observed in infected macrophages upon blockade of p53 nuclear translocation. These results reveal a previously unappreciated role for the IL-17/p53 axis in the regulation of mycobacteria-induced apoptosis and can have important implications in a broad spectrum of diseases where apoptosis of the infected cell is an important host defense mechanism.

Serviços para suporte à gestão de dados científicos: plano de intervenção dos SDUM

Os Serviços de Documentação da Universidade do Minho (SDUM) estabeleceram para os anos de 2014 e 2015 um plano de intervenção para os serviços de suporte à Gestão dos Dados Científicos na UMinho. Esta apresentação pretende resumir o plano traçado e a metodologia para a elaboração desta estratégia de atuação, identificando as áreas e os eixos de intervenção definidos pelos SDUM. Descreve algumas das ações já realizadas ou em desenvolvimento e destaca os principais resultados obtidos através de um estudo diagnóstico, realizado por questionário junto dos investigadores e centros de investigação da universidade, com o intuito de se obter um melhor conhecimento sobre o tipo de dados produzidos, as práticas de gestão associadas e averiguar a pertinência de serviços de suporte neste domínio.