Modelo para calcular a resistência à punção de lajes lisas simétricas reforçadas com fibras de aço

O presente artigo discute a metodologia de um novo modelo para calcular a resistência à punção simétrica de lajes de concreto reforçado com fibras de aço (CRFA). O modelo é fundamentado na teoria da fissura crítica de cisalhamento de Muttoni e seus coautores e na proposta do ModelCode10 para simular o comportamento pós-fissuração do CRFA. O desempenho do modelo é avaliado a partir de um banco de dados (BD), coletado da literatura técnica, que totaliza 154 lajes. Os resultados são avaliados em função da precisão, da dispersão e do nível de conservadorismo, a partir do parâmetro λ=Vexp/Vteo, sendo Vexp e Vteo, respectivamente, os resultados obtidos do BD e do modelo. Finalmente, para confirmar o desempenho do modelo, os seus resultados são comparados a outros 7 modelos da literatura técnica e ambos são classificados segundo o critério modificado de Collins, o Demerit Points Classifications – DPC.

Escavações arqueológicas no Mosteiro de S. Martinho de Tibães: campanha de janeiro de 1997 a fevereiro de 1998: Terreiro de S. João, claustro do refeitório e claustro do cemitério: relatório científico

Entre Janeiro de 1997 e Fevereiro de 1998 decorreu mais uma campanha de escavações arqueológicas no mosteiro de S. Martinho de Tibães. Conforme explicitado em relatórios e memorandos anteriores, a intervenção arqueológica visa fundamentalmente minimizar o impacte das amplas obras de consolidação, restauro e adaptação de que o edificado é objeto e que decorrerão até ao ano 2000. Subsidiariamente, os trabalhos arqueológicos visam a recolha de dados que permitam aumentar o conhecimento sobre a evolução arquitetónica do mosteiro.

Possible uses of augmented reality as a tool for guidance of users of packages

Acioly, A. S. G., Soares, M. M., & Arezes, P. M. (2015). Possible uses of augmented reality as a tool for guidance of users of packages. Paper presented at the Occupational Safety and Hygiene III - Selected Extended and Revised Contributions from the International Symposium on Safety and Hygiene.

Foreword [Occupational Safety and Hygiene III]

[Excerpt] This book is the third edition of this series of publications that are entitled “Occupational Safety and Hygiene”. The main contributions for this book were, once again, the works previously submitted and approved to be presented at the annual Symposium of the Portuguese Society of Occupational Safety and Hygiene (SPOSHO), which is celebrating its 11th edition in 2015. The SHO2015—International Symposium on Occupational Safety and Hygiene, similarly to the past seven years, was held in the School of Engineering at University of Minho in Guimarães, Portugal.

Late-medieval construction site management at the Monastery of Jerónimos in Lisbon

Through the analysis of the exceptional accounting documents of 1517 related to the construction of the Monastery of Jerónimos (Lisbon), this paper discusses the main characteristics of a new model of construction site organization. In the later Middle Ages we can find, among others, two main models of constructing site organization. One, older and more widespread, consisted in a centralized and pyramidal management model. The other, apparently more recent, was based in the existence of several autonomous teams working simultaneously, each one responsible for building a specific part or section of the building. This paper describes and discusses this new organizational model as it was adopted and implemented by João de Castilho (1470–1552) for the construction of the Monastery of Jerónimos in 1517, probably for the first time in Portugal, but with some parallels in other places in Europe.

Otimização com restrições de complementaridade: algoritmos e aplicações

Tese de Doutoramento em Engenharia Industrial e de Sistemas (PDEIS)

Racionalização de processos administrativos: Sonae SR

Dissertação de mestrado integrado em Engenharia e Gestão Industrial

Estimating the colors of paintings

Observers can adjust the spectrum of illumination on paintings for optimal viewing experience. But can they adjust the colors of paintings for the best visual impression? In an experiment carried out on a calibrated color moni- tor images of four abstract paintings obtained from hyperspectral data were shown to observers that were unfamiliar with the paintings. The color volume of the images could be manipulated by rotating the volume around the axis through the average (a*, b*) point for each painting in CIELAB color space. The task of the observers was to adjust the angle of rotation to produce the best subjective impression from the paintings. It was found that the distribution of angles selected for data pooled across paintings and observers could be de- scribed by a Gaussian function centered at 10o, i.e. very close to the original colors of the paintings. This result suggest that painters are able to predict well what compositions of colors observers prefer.

Targeting lactate transport suppresses in vivo breast tumour growth.

BACKGROUND Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as "Warburg effect". Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described MCT1 up-regulation in breast carcinoma samples and demonstrated the importance of in vitro MCT inhibition. In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment. RESULTS The effect of MCT knockdown was evaluated on lactate efflux, proliferation, cell biomass, migration and invasion and induction of tumour xenografts in nude mice. MCT knockdown led to a decrease in in vitro tumour cell aggressiveness, with decreased lactate transport, cell proliferation, migration and invasion and, importantly, to an inhibition of in vivo tumour formation and growth. CONCLUSIONS This work supports MCTs as promising targets in cancer therapy, demonstrates the contribution of MCTs to cancer cell aggressiveness and, more importantly, shows, for the first time, the disruption of in vivo breast tumour growth by targeting lactate transport.

“Fantasia Lusitana”, de João Canijo: O Portugal ficcional vs. o país real. O Estado Novo e a ‘portugalidade’. A construção da identidade

ISBN: 978-989-96858-3-3

João de Guimarães Golias, o homem e o diplomata (1599-1653)

Dissertação de mestrado em História