5 resultados para IL-18 BP
em Universidade do Minho
Resumo:
Numa sociedade e cultura em que problemáticas biopsicoafetivas nas escolas emergem a cada dia, parece justificar-se ponderar formas eficazes de prevenir comportamentos sexuais de risco. Esta Investigação-Ação inicial e exploratória tem como fundamento a avaliação-intervenção e reflexão sobre ideias/pensamentos de jovens acolhidos em Lares de Infância e Juventude (LIJs), no sentido de se entender melhor o impacto de fatores de risco e de fatores de equilíbrio/moderadores, em LIJ´s, com condições de vida problemáticas associadas: orfandade, situação socioeconómica frágil, exposição a modelos educativos desajustados, entre outros critérios de relação e cultura distinta de “meios naturais de vida”. Parecem evidentes as consequências negativas do afastamento familiar, absentismo escolar, limitações de competências sociais-pessoais, para se melhorar/potenciar a existência de menores. Compreendem-se dificuldades na área da implementação da Educação Sexual, consistente e prolongada, assim como a emergência de condutas psicossexuais desajustadas, que possam comprometer uma sexualidade saudável. Assim, foram efetuadas entrevistas semiestruturadas a 8 jovens, de 18-26 anos, antigos residentes de LIJs, com permanência (prolongada), excedendo os quatro anos, o que possibilita apresentar, por método e técnicas de Analise de Discurso, conceções de sexualidade e consequentemente poder delinear um plano interventivo com outros mais jovens. Entre outros dados, apreende-se que nenhum dos participantes refere motivos plenos para a sua institucionalização, ignorando ou rejeitando a adversidade e maus tratos/abuso na sua infância.
Resumo:
Within a research project on «academic excellence in the state school», this paper is a contribution to the sociological reflection on the cultural and organisational characteristics of the school and its relationship with the academic success of students. The data we present stem from a case study underway at a secondary school in the north of Portugal, referring to the universe of students that since 2003 have distinguished themselves for achieving grades equal to or greater than 18 (on a scale of 0 to 20) and have thus been included in the school’s Framework of Excellence. From a contextual approach to this educational practice, we focused on the cultural characteristics of the school/subject as analytical support for the study of school and non-school dimensions in their mutual connections. To this end, we used the information from document analysis and data collected from a questionnaire survey administered to more than two-thirds of the students included in the above-mentioned Framework of Excellence. Subsequently, we will use the data from this survey to understand the extent to which academic excellence is perceived as an indivisible social construction of the school’s political and organisational matrix, particularly in terms of the educational and teaching guidelines adopted by the management body. We will conclude by questioning the meaning of the school’s management policies regarding the emphasis on educational outcomes, with particular focus on the representations of excellent students in the processes of school leadership, teaching organisation, school merit and justice.
Resumo:
The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL-17 inhibits p53, and impacts on the intrinsic apoptotic pathway, by increasing the Bcl2 and decreasing Bax expression, decreasing cytochrome c release from the mitochondria, and inhibiting caspase-3 activation. The same effect of IL-17 was observed in infected macrophages upon blockade of p53 nuclear translocation. These results reveal a previously unappreciated role for the IL-17/p53 axis in the regulation of mycobacteria-induced apoptosis and can have important implications in a broad spectrum of diseases where apoptosis of the infected cell is an important host defense mechanism.
Resumo:
The sol-gel method was employed in the synthesis of di-urethane cross-linked poly( caprolactone) (PCL(530)/siloxane biohybrid ormolytes incorporating either a mixture of lithium triflate (LiCF3SO3) and the ionic liquid (IL) 1-ethyl-3-methyl imidazolium tetrafluoroborate ([Emim]BF4), or solely with [Emim]BF4 or LiCF3SO3. The ormolyte doped with [Emim]BF4 is thermally more stable and exhibits higher ionic conductivity (4 x 10-4 and 2 x 10-3 S cm-1 at 36 and 98 ºC, respectively) than those containing the LiCF3SO3/[Emim]BF4 mixture or just LiCF3SO3. The three ormolytes were employed in the production of glass/ITO/ormolyte/WO3/ITO/glass electrochromic devices (ECDs) designated as ECD@Y with Y = Li-[Emim]BF4, [Emim]BF4 and Li. The three ECDs displayed fast switching speed (ca. 30 s). ECD@Li-[Emim]BF4 exhibited an electrochromic contrast of 18.4 % and an optical density change of 0.11 in the visible region, the coloration efficiency attained at 555 nm was 159 and 80.2 cm-2 C-1 in the “on” and “off” states, respectively, and the open circuit memory was 48 hours. In the “on” state the CIE 1931 color space coordinates were x = 0.29 and y = 0.30, corresponding to blue color.
Resumo:
Tese de Doutoramento em Medicina.