Production of mexican brown macroalgae fucoidan and fucosidases under an integral green technology bioproceses by the biorefinery concept

Marine ecosystem can be considered a rather exploited source of natural substances with enormous bioactive potential. In Mexico macro-algae study remain forgotten for research and economic purposes besides the high amount of this resource along the west and east coast. For that reason the Bioferinery Group of the Autonomous University of Coahuila, have been studying the biorefinery concept in order to recover high value byproducts of Mexican brown macro-algae including polysaccharides and enzymes to be applied in food, pharmaceutical and energy industry. Brown macroalgae are an important source of fucoidan, alginate and laminarin which comprise a complex group of macromolecules with a wide range of important biological properties such as anticoagulant, antioxidant, antitumoral and antiviral and also as rich source of fermentable sugars for enzymes production. Additionally, specific enzymes able to degrade algae matrix (fucosidases, sulfatases, aliginases, etc) are important tools to establish structural characteristics and biological functions of these polysaccharides. The aims of the present work were the integral study of bioprocess for macroalgae biomass exploitation by the use of green technologies as hydrothermal extraction and solid state fermentation in order to produce polysaccharides and enzymes (fucoidan and fucoidan hydrolytic enzymes). This work comprises the use of the different bioprocess phases in order to produce high value products with lower time and wastes.

“Big Brother”: um programa que mapeou a informação televisiva

(Excerto) Poder-se-á dizer que há uma informação televisiva “pré” e “pós” “Big Brother”? Detendo-nos nos programas de informação não-diária dos canais generalistas portugueses, procuraremos perceber de que forma o horário nobre, nomeadamente dos canais privados, se esvaziou desse tipo de programação. Esta é uma pequena parte de uma investigação que estamos a desenvolver no projecto de doutoramento e, por outro lado, integra-se num trabalho do grupo Mediascópio que recentemente analisou casos que, no início deste século, alteraram o modo de encarar/fazer jornalismo. Tendo aqui como referência os anos de 1999 (altura em que ainda não estavam no ar as chamadas “novelas da vida real”) e de 2003 (ano após o qual todos os canais generalistas já tinham emitido esse tipo de programas), procederemos a uma análise da informação não-diária no segmento do “prime time”, salientando as tendências do jornalismo televisivo que, nos últimos anos, se vem desenhando no pequeno ecrã.

Triple negative breast cancer: nanosolutions for a big challenge

Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.

Text mining na análise de sentimentos em contextos de big data

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

Big data e data analysis: visualização de informação

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação