Nanocomposites: the contribution of multiscale modelling to improve the dispersion levels

Tese de Doutoramento em Ciência e Engenharia de Polímeros e Compósitos

Evolution of the gene regulatory network controlling flower dorsoventral asymmetry

Tese de Doutoramento em Biologia de Plantas.

Avaliação da sustentabilidade de soluções construtivas para a reabilitação da envolvente exterior dos edifícios

Dissertação de mestrado Internacional em Sustentabilidade do Ambiente Construído

Avaliação de vigas de madeira de Castanho tendo por base a classificação visual e ensaios não destrutivos

Dissertação de mestrado Internacional em Sustentabilidade do Ambiente Construído

Indicadores chave de sustentabilidade para edifícios residenciais em estrutura metálica

Dissertação de mestrado integrado em Engenharia Civil

Literatura russa em Portugal: das vias de difusão aos sentidos de receção: o caso de Leão Tolstói

Tese de Doutoramento em Ciências da Literatura (área de especialização em Literatura Comparada).

Modelação numérica de túneis com consideração explícita das heterogeneidades do maciço

Dissertação de mestrado integrado em Engenharia Civil

Development of Janus hydrogel microcapsules as novel biomaterials-stem cells construct for 3D co-culture applications

Co-cultures of two or more cell types and biodegradable biomaterials of natural origin have been successfully combined to recreate tissue microenvironments. Segregated co-cultures are preferred over conventional mixed ones in order to better control the degree of homotypic and heterotypic interactions. Hydrogel-based systems in particular, have gained much attention to mimic tissue-specific microenvironments and they can be microengineered by innovative bottom-up approaches such as microfluidics. In this study, we developed bi-compartmentalized (Janus) hydrogel microcapsules of methacrylated hyaluronic acid (MeHA)/methacrylated-chitosan (MeCht) blended with marine-origin collagen by droplet-based microfluidics co-flow. Human adipose stem cells (hASCs) and microvascular endothelial cells (hMVECs) were co-encapsulated to create platforms of study relevant for vascularized bone tissue engineering. A specially designed Janus-droplet generator chip was used to fabricate the microcapsules (<250â μm units) and Janus-gradient co-cultures of hASCs: hMVECs were generated in various ratios (90:10; 75:25; 50:50; 25:75; 10:90), through an automated microfluidic flow controller (Elveflow microfluidics system). Such monodisperse 3D co-culture systems were optimized regarding cell number and culture media specific for concomitant maintenance of both phenotypes to establish effective cell-cell (homotypic and heterotypic) and cell-materials interactions. Cellular parameters such as viability, matrix deposition, mineralization and hMVECs re-organization in tube-like structures, were enhanced by blending MeHA/MeCht with marine-origin collagen and increasing hASCs: hMVECs co-culture gradient had significant impact on it. Such Janus hybrid hydrogel microcapsules can be used as a platform to investigate biomaterials interactions with distinct combined cell populations.

Bioactive ceramics for tissue engineering and regenerative medicine derived from marine sponges

Publicado em "Journal of tissue engineering and regenerative medicine". Vol. 8, suppl. s1 (2014)

Arquitetura e paisagem monásticas no território bracarense: o caso de Dume (S. Martinho)

Dissertação de mestrado em Arqueologia

O hospital da misericórdia de Penafiel (1600-1850)

Tese de Doutoramento em História - Especialidade de Idade Moderna

Relacionamentos em MMORPGs: online e offline

Dissertação de mestrado em Comunicação, Arte e Cultura

Factoriality and the pin-reutenauer procedure

We consider implicit signatures over finite semigroups determined by sets of pseudonatural numbers. We prove that, under relatively simple hypotheses on a pseudovariety V of semigroups, the finitely generated free algebra for the largest such signature is closed under taking factors within the free pro-V semigroup on the same set of generators. Furthermore, we show that the natural analogue of the Pin-Reutenauer descriptive procedure for the closure of a rational language in the free group with respect to the profinite topology holds for the pseudovariety of all finite semigroups. As an application, we establish that a pseudovariety enjoys this property if and only if it is full.

Empresas sociais em Portugal: que realidade?

Dissertação de mestrado em Economia Social

Cessação do vínculo de emprego público: “a conjuntura jurídica dos contratados”

Dissertação de mestrado em Direito Administrativo (área de especialização em Emprego Público)