50 resultados para Bismut Connection
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Dissertação de mestrado em Psicologia Aplicada
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Tese de Doutoramento em Engenharia Civil.
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Dissertação de mestrado em Direito Tributário e Fiscal
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In this paper, we investigate the reducibility property of semidirect products of the form V *D relatively to (pointlike) systems of equations of the form x1 =...= xn, where D denotes the pseudovariety of definite semigroups. We establish a connection between pointlike reducibility of V*D and the pointlike reducibility of the pseudovariety V. In particular, for the canonical signature consisting of the multiplication and the (omega-1)-power, we show that V*D is pointlike-reducible when V is pointlike-reducible.
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Dissertação de mestrado em Design e Marketing
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Dissertação de mestrado em Design e Marketing
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Insoluble and fibrillar forms of a-synuclein are the major components of Lewy bodies, a hallmark of several sporadic and inherited neurodegenerative diseases known as synucleinopathies. a-Synuclein is a natural unfolded and aggregation-prone protein that can be degraded by the ubiquitin-proteasomal system and the lysosomal degradation pathways. a-Synuclein is a target of the main cellular proteolytic systems, but it is also able to alter their function further, contributing to the progression of neurodegeneration. Aging, a major risk for synucleinopathies, is associated with a decrease activity of the proteolytic systems, further aggravating this toxic looping cycle. Here, the current literature on the basic aspects of the routes for a-synuclein clearance, as well as the consequences of the proteolytic systems collapse, will be discussed. Finally, particular focus will be given to the sirtuins's role on proteostasis regulation, since their modulation emerged as a promising therapeutic strategy to rescue cells from a-synuclein toxicity. The controversial reports on the potential role of sirtuins in the degradation of a-synuclein will be discussed. Connection between sirtuins and proteolytic systems is definitely worth of further studies to increase the knowledge that will allow its proper exploration as new avenue to fight synucleinopathies.
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Dissertação de mestrado integrado em Arquitectura
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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e Computadores
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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e Computadores
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Dissertação de mestrado integrado em Arquitectura (área de especialização em Cultura Arquitetónica)
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Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação
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Dissertação de mestrado em Biologia Molecular, Biotecnologia e Bioempreendedorismo em Plantas
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Dissertação de mestrado integrado em Engenharia Mecânica
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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e de Computadores