1 resultado para MARINE NATURAL-PRODUCT
em Institutional Repository of Leibniz University Hannover
Filtro por publicador
- Repository Napier (1)
- Aberdeen University (5)
- Aberystwyth University Repository - Reino Unido (2)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (4)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- Aquatic Commons (59)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (14)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (6)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (37)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (39)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Biodiversity Heritage Library, United States (5)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (31)
- Boston University Digital Common (1)
- Brock University, Canada (6)
- Bucknell University Digital Commons - Pensilvania - USA (2)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (13)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (23)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (65)
- Cochin University of Science & Technology (CUSAT), India (29)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (12)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (39)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (8)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (4)
- DigitalCommons@University of Nebraska - Lincoln (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (6)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (4)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (3)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (54)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico de Viseu (2)
- Instituto Politécnico do Porto, Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Memorial University Research Repository (2)
- National Center for Biotechnology Information - NCBI (22)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (73)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- Publishing Network for Geoscientific & Environmental Data (85)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (40)
- Queensland University of Technology - ePrints Archive (35)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (122)
- SAPIENTIA - Universidade do Algarve - Portugal (4)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (3)
- Universidad Politécnica de Madrid (6)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade dos Açores - Portugal (1)
- Universidade Federal do Pará (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (8)
- Universitat de Girona, Spain (1)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Connecticut - USA (1)
- University of Michigan (9)
- University of Queensland eSpace - Australia (32)
- University of Washington (5)
Resumo:
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. We have proposed that desertomycin A and similar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl-CoA but with 4-guanidinylbutanoyl-CoA, to avoid facile cyclization of the starter unit. This hypothesis requires that there be a final-stage de-amidination of the corresponding guanidino-substituted natural product, but no enzyme for such a process has been described. We have now identified candidate amidinohydrolase genes within the desertomycin and primycin clusters. Deletion of the putative desertomycin amidinohydrolase gene dstH in Streptomyces macronensis led to the accumulation of desertomycin B, the guanidino form of the antibiotic. Also, purified DstH efficiently catalyzed the in vitro conversion of desertomycin B into the A form. Hence this amidinohydrolase furnishes the missing link in this proposed naturally evolved example of protective-group chemistry.