1 resultado para Evaluation model
em Institutional Repository of Leibniz University Hannover
Filtro por publicador
- JISC Information Environment Repository (1)
- Repository Napier (1)
- Aberdeen University (1)
- Aberystwyth University Repository - Reino Unido (5)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (5)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (7)
- Aston University Research Archive (17)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (7)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (19)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (2)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (19)
- Boston University Digital Common (2)
- Brock University, Canada (5)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (30)
- CentAUR: Central Archive University of Reading - UK (142)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (29)
- Cochin University of Science & Technology (CUSAT), India (5)
- Collection Of Biostatistics Research Archive (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Cornell: DigitalCommons@ILR (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (1)
- Dalarna University College Electronic Archive (8)
- Deakin Research Online - Australia (28)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (10)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (4)
- Diposit Digital de la UB - Universidade de Barcelona (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (8)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (13)
- Greenwich Academic Literature Archive - UK (10)
- Helda - Digital Repository of University of Helsinki (7)
- Indian Institute of Science - Bangalore - Índia (59)
- Institutional Repository of Leibniz University Hannover (1)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (2)
- Instituto Politécnico de Bragança (2)
- Instituto Politécnico do Porto, Portugal (5)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Massachusetts Institute of Technology (3)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- Ministerio de Cultura, Spain (4)
- National Center for Biotechnology Information - NCBI (1)
- Open University Netherlands (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (66)
- Queensland University of Technology - ePrints Archive (198)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (3)
- Repositório Aberto da Universidade Aberta de Portugal (2)
- REPOSITÓRIO ABERTO do Instituto Superior Miguel Torga - Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (6)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (3)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (4)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (10)
- Repositório Institucional da Universidade de Brasília (3)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (25)
- Repositorio Institucional Universidad de Medellín (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (8)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (6)
- Universidad Politécnica de Madrid (17)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universitat de Girona, Spain (4)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (5)
- Université de Lausanne, Switzerland (9)
- Université de Montréal (1)
- Université de Montréal, Canada (17)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (1)
- University of Michigan (19)
- University of Queensland eSpace - Australia (10)
- University of Washington (1)
- WestminsterResearch - UK (5)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Statistical association between a single nucleotide polymorphism (SNP) genotype and a quantitative trait in genome-wide association studies is usually assessed using a linear regression model, or, in the case of non-normally distributed trait values, using the Kruskal-Wallis test. While linear regression models assume an additive mode of inheritance via equi-distant genotype scores, Kruskal-Wallis test merely tests global differences in trait values associated with the three genotype groups. Both approaches thus exhibit suboptimal power when the underlying inheritance mode is dominant or recessive. Furthermore, these tests do not perform well in the common situations when only a few trait values are available in a rare genotype category (disbalance), or when the values associated with the three genotype categories exhibit unequal variance (variance heterogeneity). We propose a maximum test based on Marcus-type multiple contrast test for relative effect sizes. This test allows model-specific testing of either dominant, additive or recessive mode of inheritance, and it is robust against variance heterogeneity. We show how to obtain mode-specific simultaneous confidence intervals for the relative effect sizes to aid in interpreting the biological relevance of the results. Further, we discuss the use of a related all-pairwise comparisons contrast test with range preserving confidence intervals as an alternative to Kruskal-Wallis heterogeneity test. We applied the proposed maximum test to the Bogalusa Heart Study dataset, and gained a remarkable increase in the power to detect association, particularly for rare genotypes. Our simulation study also demonstrated that the proposed non-parametric tests control family-wise error rate in the presence of non-normality and variance heterogeneity contrary to the standard parametric approaches. We provide a publicly available R library nparcomp that can be used to estimate simultaneous confidence intervals or compatible multiplicity-adjusted p-values associated with the proposed maximum test.