46 resultados para Drug delivery system
Filtro por publicador
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (5)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (16)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (6)
- Aston University Research Archive (79)
- B-Digital - Universidade Fernando Pessoa - Portugal (2)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (17)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (4)
- Bioline International (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (27)
- Bucknell University Digital Commons - Pensilvania - USA (2)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (26)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (29)
- Cochin University of Science & Technology (CUSAT), India (2)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Deakin Research Online - Australia (65)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (4)
- Digital Commons @ DU | University of Denver Research (2)
- Digital Commons at Florida International University (13)
- DigitalCommons@The Texas Medical Center (10)
- DRUM (Digital Repository at the University of Maryland) (5)
- Duke University (3)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (3)
- FUNDAJ - Fundação Joaquim Nabuco (6)
- Greenwich Academic Literature Archive - UK (7)
- Helda - Digital Repository of University of Helsinki (5)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (2)
- Indian Institute of Science - Bangalore - Índia (46)
- Institutional Repository of Leibniz University Hannover (1)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (2)
- Instituto Politécnico do Porto, Portugal (3)
- Massachusetts Institute of Technology (2)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (6)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (163)
- Queensland University of Technology - ePrints Archive (68)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (149)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- The Scholarly Commons | School of Hotel Administration; Cornell University Research (1)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (6)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (11)
- Université de Lausanne, Switzerland (2)
- Université de Montréal (1)
- Université de Montréal, Canada (17)
- University of Innsbruck Digital Library - Austria (1)
- University of Michigan (5)
- University of Queensland eSpace - Australia (39)
- University of Washington (3)
- WestminsterResearch - UK (3)
Resumo:
We report the fabrication of dual enzyme responsive hollow nanocapsules which can be targeted to deliver anticancer agents specifically inside cancer cells. The enzyme responsive elements, integrated in the nanocapsule walls, undergo degradation in the presence of either trypsin or hyaluronidase leading to the release of encapsulated drug molecules. These nanocapsules, which were crosslinked and functionalised with folic acid, showed minimal drug leakage when kept in pH 7.4 PBS buffer, but released the drug molecules at a rapid rate in the presence of either one of the triggering enzymes. Studies on cellular interactions of these nanocapsules revealed that doxorubicin loaded nanocapsules were taken up by cervical cancer cells via folic acid receptor medicated endocytosis. Interestingly the nanocapsules were able to disintegrate inside the cancer cells and release doxorubicin which then migrated into the nucleus to induce cell death. This study indicates that these nanocapsules fabricated from biopolymers can serve as an excellent platform for targeted intracellular drug delivery to cancer cells.