1 resultado para breast tumor
em Illinois Digital Environment for Access to Learning and Scholarship Repository
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (4)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (8)
- Aston University Research Archive (1)
- B-Digital - Universidade Fernando Pessoa - Portugal (3)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (26)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (9)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (9)
- Bioline International (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (45)
- Boston University Digital Common (3)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (3)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (36)
- Cochin University of Science & Technology (CUSAT), India (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Cornell: DigitalCommons@ILR (1)
- Deakin Research Online - Australia (23)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (27)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (3)
- DigitalCommons@The Texas Medical Center (56)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (7)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (54)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (59)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico do Porto, Portugal (1)
- National Center for Biotechnology Information - NCBI (36)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (37)
- Queensland University of Technology - ePrints Archive (367)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (2)
- Repositorio Institucional de la Universidad Nacional Agraria (1)
- Repositorio Institucional de la Universidad Pública de Navarra - Espanha (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (72)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Scientific Open-access Literature Archive and Repository (3)
- Universidad del Rosario, Colombia (2)
- Universidad Politécnica de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (1)
- Universidade Técnica de Lisboa (1)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (6)
- Université de Montréal (1)
- Université de Montréal, Canada (4)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (1)
- University of Queensland eSpace - Australia (10)
- University of Washington (1)
Resumo:
Estrogens can be labeled with the positron-emitting radionuclide fluorine-18 (t$\sb{1/2}$ = 110 min) by fluoride ion (n-Bu$\sb4$N$\sp{18}$F) displacement of a 16$\beta$-trifluoromethanesulfonate (triflate) derivative of the corresponding estrone 3-triflate, and purification by HPLC. That sequence has been used to synthesize the 11$\beta$-methoxy 1 and 11$\beta$-ethyl 2 analogues of the breast tumor imaging agent, 16$\alpha$-($\sp{18}$F) fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios being 43 and 17 at one hour after injection for 1 and 2, respectively. The parent estrogen FES has previously been shown to display an intermediate value for tissue selectivity.