Individual Differences in Reactions to Peer Victimization: The Moderating Role of Temperament and Sex

This study examined whether temperamental traits and sex moderate the effects of peer victimization on children’s adjustment over a year to identify factors that put victimized children at heightened risk for adjustment difficulties. Children (N = 282; M age = 7.94 years, SD = 0.32) and teachers reported on exposure to peer victimization. Parents provided ratings of children’s temperament (i.e., inhibitory control and negative emotionality) and depressive symptoms, and teachers provided ratings of children’s aggression. Results revealed that overt victimization predicted aggression in girls with low levels of inhibitory control. Results also revealed that total victimization predicted depressive symptoms in girls with high levels of negative emotionality and in boys with low levels of negative emotionality. This research identifies temperament and sex as contributors to individual differences in children’s reactions to peer victimization. The findings are discussed in the context of temperament x environment and diathesis-stress frameworks.

Studies of Protein-Protein and Protein-Water Interactions by Small Angle X-Ray Scattering, Terahertz Spectroscopy, ASMOS, And Computer Simulation

The protein folding problem has been one of the most challenging subjects in biological physics due to its complexity. Energy landscape theory based on statistical mechanics provides a thermodynamic interpretation of the protein folding process. We have been working to answer fundamental questions about protein-protein and protein-water interactions, which are very important for describing the energy landscape surface of proteins correctly. At first, we present a new method for computing protein-protein interaction potentials of solvated proteins directly from SAXS data. An ensemble of proteins was modeled by Metropolis Monte Carlo and Molecular Dynamics simulations, and the global X-ray scattering of the whole model ensemble was computed at each snapshot of the simulation. The interaction potential model was optimized and iterated by a Levenberg-Marquardt algorithm. Secondly, we report that terahertz spectroscopy directly probes hydration dynamics around proteins and determines the size of the dynamical hydration shell. We also present the sequence and pH-dependence of the hydration shell and the effect of the hydrophobicity. On the other hand, kinetic terahertz absorption (KITA) spectroscopy is introduced to study the refolding kinetics of ubiquitin and its mutants. KITA results are compared to small angle X-ray scattering, tryptophan fluorescence, and circular dichroism results. We propose that KITA monitors the rearrangement of hydrogen bonding during secondary structure formation. Finally, we present development of the automated single molecule operating system (ASMOS) for a high throughput single molecule detector, which levitates a single protein molecule in a 10 µm diameter droplet by the laser guidance. I also have performed supporting calculations and simulations with my own program codes.