Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain

Estrogens can be labeled with the positron-emitting radionuclide fluorine-18 (t$\sb{1/2}$ = 110 min) by fluoride ion (n-Bu$\sb4$N$\sp{18}$F) displacement of a 16$\beta$-trifluoromethanesulfonate (triflate) derivative of the corresponding estrone 3-triflate, and purification by HPLC. That sequence has been used to synthesize the 11$\beta$-methoxy 1 and 11$\beta$-ethyl 2 analogues of the breast tumor imaging agent, 16$\alpha$-($\sp{18}$F) fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios being 43 and 17 at one hour after injection for 1 and 2, respectively. The parent estrogen FES has previously been shown to display an intermediate value for tissue selectivity.

An experimental investigation of air flow and convective heat transfer in enclosures having large ventilative flow rates

The prediction of convective heat transfer in enclosures under high ventilative flow rates is primarily of interest for building design and simulation purposes. Current models are based on experiments performed forty years ago with flat plates under natural convection conditions.

Algebraic geometric codes over rings

The techniques of algebraic geometry have been widely and successfully applied to the study of linear codes over finite fields since the early 1980's. Recently, there has been an increased interest in the study of linear codes over finite rings. In this thesis, we combine these two approaches to coding theory by introducing and studying algebraic geometric codes over rings.