Kun kansa itse ratkaisee arvoituksen. Tattarisuon tapauksen määrittely käytännöllisessä diskurssissa

Pro gradu -tutkielmani käsittelee vuoden 1931 syyskuussa Helsingin lähistöllä paljastunutta ruumiinsilvontarikosta, joka tunnetaan yleisimmin Tattarisuon tapauksen nimellä. Rikoksen selvittäminen osoittautui vaikeaksi, ja poliisi ratkaisi sen monien vaiheiden jälkeen vasta vuoden 1932 elokuussa. Syylliset olivat köyhiä helsinkiläisiä, joiden vaikuttimet liittyivät taikauskoon. Tattarisuon tapaus synnytti syksyllä 1931 suuren mediakohun, josta kirjoitettiin suomalaisissa sanomalehdissä lähes päivittäin. Tapauksen alkuvaiheessa tiedot olivat vähäisiä, joten erilaiset huhut ja tapauksen ratkaisemiseksi kehitetyt teoriat olivat lehtikirjoituksissa näkyvällä sijalla. Niin ikään lehtiä seuranneen yleisön piirissä kehitettiin tapauksesta omia tulkintoja, joista osa saatettiin myös viranomaisten tiedoksi näille lähetetyissä vihjekirjeissä. Tutkielman aineisto koostuu enimmäkseen edellä mainituista sanomalehtikirjoituksista ja vihjekirjeistä, joita tutkin laadullisen sisällönanalyysin keinoin. Tarkoitukseni on selvittää, miten ja miksi Tattarisuon tapauksen johdosta julkisuudessa esitetyt teoriat erosivat sekä toisistaan että poliisin myöhemmin esittämästä ratkaisusta. Työssä käytetyn julkisuuden käsitteen olen mukaillut Hannu Niemisen kansallisen julkisuuden käsitteestä. Aineiston analyysissa on käynyt ilmi, että lehdistöä kontrolloivien kansallisten eliittien oli vaikea hyväksyä sitä, että rikos perustui kansanomaiseen taikauskoon. Eliitit kokivat tällaisen taikauskon esiintymisen Helsingin läheisyydessä vielä 1930-luvulla häpeälliseksi pääkaupungin ja koko Suomen kannalta sekä pelkäsivät tämän vaikuttavan negatiivisesti Suomesta ulkomailla vallitseviin käsityksiin. Vihjekirjeiden perusteella tapausta seuranneen yleisön tulkinnat olivat rauhallisempia, sillä suuri osa yleisöstä näyttää olleen tietoinen taikauskon levinneisyydestä.

Fatigued driving : prevalence, risk factors and groups, and the law

Fatigue and sleepiness are major causes of road traffic accidents. However, precise data is often lacking because a validated and reliable device for detecting the level of sleepiness (cf. the breathalyzer for alcohol levels) does not exist, nor does criteria for the unambiguous detection of fatigue/sleepiness as a contributing factor in accident causation. Therefore, identification of risk factors and groups might not always be easy. Furthermore, it is extremely difficult to incorporate fatigue in operationalized terms into either traffic or criminal law. The main aims of this thesis were to estimate the prevalence of fatigue problems while driving among the Finnish driving population, to explore how VALT multidisciplinary investigation teams, Finnish police, and courts recognize (and prosecute) fatigue in traffic, to identify risk factors and groups, and finally to explore the application of the Finnish Road Traffic Act (RTA), which explicitly forbids driving while tired in Article 63. Several different sources of data were used: a computerized database and the original folders of multidisciplinary teams investigating fatal accidents (VALT), the driver records database (AKE), prosecutor and court decisions, a survey of young male military conscripts, and a survey of a representative sample of the Finnish active driving population. The results show that 8-15% of fatal accidents during 1991-2001 were fatigue related, that every fifth Finnish driver has fallen asleep while driving at some point during his/her driving career, and that the Finnish police and courts punish on average one driver per day on the basis of fatigued driving (based on the data from the years 2004-2005). The main finding regarding risk factors and risk groups is that during the summer months, especially in the afternoon, the risk of falling asleep while driving is increased. Furthermore, the results indicate that those with a higher risk of falling asleep while driving are men in general, but especially young male drivers including military conscripts and the elderly during the afternoon hours and the summer in particular; professional drivers breaking the rules about duty and rest hours; and drivers with a tendency to fall asleep easily. A time-of-day pattern of sleep-related incidents was repeatedly found. It was found that VALT teams can be considered relatively reliable when assessing the role of fatigue and sleepiness in accident causation; thus, similar experts might be valuable in the court process as expert witnesses when fatigue or sleepiness are suspected to have a role in an accident’s origins. However, the application of Article 63 of the RTA that forbids, among other things, fatigued driving will continue to be an issue that deserves further attention. This should be done in the context of a needed attitude change towards driving while in a state of extreme tiredness (e.g., after being awake for more than 24 hours), which produces performance deterioration comparable to illegal intoxication (BAC around 0.1%). Regarding the well-known interactive effect of increased sleepiness and even small alcohol levels, the relatively high proportion (up to 14.5%) of Finnish drivers owning and using a breathalyzer raises some concern. This concern exists because these drivers are obviously more focused on not breaking the “magic” line of 0.05% BAC than being concerned about driving impairment, which might be much worse than they realize because of the interactive effects of increased sleepiness and even low alcohol consumption. In conclusion, there is no doubt that fatigue and sleepiness problems while driving are common among the Finnish driving population. While we wait for the invention of reliable devices for fatigue/sleepiness detection, we should invest more effort in raising public awareness about the dangerousness of fatigued driving and educate drivers about how to recognize and deal with fatigue and sleepiness when they ultimately occur.

Linnunkiikut ja kallen kaulukset : Kotitekoiset kuukautissiteet 1900-luvun alkupuolen Suomessa

The aim of this thesis was to study what kind of home-made menstrual pads were used in the early 20th century in Finland, how the home-made pads were made and which techniques and materials were used. The use and taking care of menstrual pads were also explored. The history of menstrual pads has been studied in Sweden, Germany and United States but none of those studies has concentrated on home-made pads. Instead, there are many studies about womanhood and menstruation. In many studies home-made menstrual pads are only briefly mentioned. Menstrual pads were not commonly used in Finland at the beginning of the 20th century, but already in the 1940s the use of menstrual pads had become common in every stratum of society. Home-made menstrual pads were used even until the 1960s. In Finland, factory-made disposable menstrual pads became common only in the 1930s and they were only slowly accepted. The study material consisted of nine interviews, three archival inquiries, health care guidebooks from 1893 to 1943 and authentic menstrual pads, menstrual belts and other objects related to them. The interviewed women were born between 1915 and 1939. The narrative approach was used in the study and it also guided the analysis. The interview and archival data were studied according to the basic rules of oral history studies. Literature consisted of publications from several disciplines. The extensive primary material played the most important role in this study. The reconstructions of the menstrual pads were made according to the interviewed women s advice. In Finland there were innumerable variations of home-made menstrual pads. The pads were most commonly crocheted and knitted either by hand or by knitting machine. Pads were also sewn of cloth, old bed linen or old underwear. The menstrual pads were self-made or made by a female relative. Word of mouth was important in spreading information on how to make pads, because there were hardly any instructions available. The biggest pads were 54 cm long and 13 cm wide. The most widely used pad model was a rectangle, which had triangle-shaped ends with a buttonhole or a loop. The pad was attached to the menstrual belt or to the buttons of the suspender belt. Knitted and crocheted pads had one, two or three layers. In sewn pads, there could be even more layers. Cellulose wadding or pieces of cloth could be placed inside the pad to increase the absorption ability. The experiences of the comfort of self-made pads varied. The crocheted and sewn pads were found chafing, knitted ones were found soft and comfortable. The menstrual pads were laborious to wash and boil in lye water. Therefore disposable pads made everyday life easier. The home-made menstrual pads were part of a unique tradition of handicrafts and folk culture. Hand-made pads were one of the most common handicraft products and were a part of every woman s life. Even so, the menstrual pads were unnoticeable. The large number of variations was probably caused by the silence around menstrual topics and by the lack of instructions for making pads. Variations are also explained by the uniqueness of every handicraft product. In Finland the home-made pads were used until relatively recent times. This was caused by the conditions of wartime and the following years and the rarity of commercial pads. Furthermore, until the late 20th century Finland was an agricultural society where all innovations spread slowly. Home-made menstrual pad was a secret handicraft of women and every woman needed to know how to make it by herself.

Ett' varttuisi Suomenmaa : Suomalaisten kasvattaminen kulutusyhteiskuntaan kotimaisissa lyhytelokuvissa 1920-1969

The birth of the Modern Consumer Society in Finnish short films 1920-1969 The main subject of this research is Finnish short films in 1920-1969. These short films were produced by film studios for private enterprises, banks, advisory organizations, communities and the state. The evolution of short films on consumer affairs was greatly influenced by a special tax reduction system that was introduced in 1933 and lasted until 1964. The tax reduction system increased the production volumes of educational short films significantly. This study covers 342 Finnish short films, more than any other study in the field before this. The aim of this research is to examine how short films introduced Finns to modern consumer society. The cinemagoers were an excellent target group for different advisory groups as well as advertisers. Short films were used by organizations and private enterprises from very early on. In the 1920's Finns were still living in rural areas and agriculture was the dominant industry. Consumer society was still in its infancy, and the prevalent attitude to industrially produced goods was that of suspicion. From the cultural and ideological point of view the evolution of trust was one of the first steps towards the birth of the consumer society. Short films were an excellent means for helping to transform public attitudes. During the war period short films were an important means of propaganda. Short films were produced in abundance and shown for big audiences. They guided people how to survive shortages caused by the war. Even though the idea of rationalization was presented in short films somewhat in the 1920's and 1930's it became a national virtue during the war period. The idea of rationalization widened from the industry to households expecially in the late 1940's and the 1950's. New household apparati and the way in which daily chores were taken care of were presented not as luxury consumption but as a way of rationalization and saving money and effort. Banks and the advisory organizations guided the public to save their money for a specific target. Short films were use to help the public to acceps industrial goods and the notions of planning and saving. The ideological change from an agrarian society to consumer society was based on old acricultural ideas and self-sufficiency was evolved into rational and economizing consumerism. This made Finnish consumer society to value durable consumer goods and own homes. The public was also encouraged to consider their own decisions in the national context - especially after the second world war Finland laced capital, and personal savings were strongly presented as a way to help the whole nation. Modern hedonistic values were not dominant in Finland in the1950's and 1960's. Initial traces of modern hedonism can be seen in the films, but they were only marginal paths in the bigger.

"Köyhyydestä ei puhuttu, sitä vaan elettiin." : Köyhyyden kokemus ja selviytyminen 1930-luvun pulan oloissa Suomen maaseudulla

On the material level of poverty, the work shows how the Great Depression forced rural women and children to enhance their work input and find new ways of coping. The most serious impact of the Depression was poor nutrition, as well as scarcity of food and clothes. Women's and men's ways to make a living started to resemble each other; men had also to consent to wages in form of foodstuff. The research also focuses on immaterial poverty by means of exploring experiences of otherness: shame, hatred and expressions of protest. Substantial humiliation was induced by poor relief and begging. A clear gap prevailed between the poor and the better off people in school, work and at leisure. The economic crisis deepened this gap even further. The dissertation specifies the poor people s every day experiences by taking into account the different worlds of men and women. The analysis of four different memory-based sources is the core in the micro-historical research design. The narrators of the research were survivors, unlike many others, who experienced the Great Depression. Moralization and humiliation of the poor have not ceased in contemporary society. Therefore, the historical perspective of both the material and the immaterial side of poverty could increase the understanding of the multifaceted phenomenon of today s poverty.

Corneal recovery after uncomplicated and complicated PRK and LASIK

Refractive errors, especially myopia, seem to increase worldwide. Concurrently, the number of surgical refractive corrections has increased rapidly, with several million procedures performed annually. However, excimer laser surgery was introduced after a limited number of studies done with animals and to date there still are only few long-term follow-up studies of the results. The present thesis aims to evaluate the safety and functional outcome of, as well as to quantify the cellular changes and remodelling in the human cornea after, photorefractive keratectomy (PRK) and laser assisted in situ keratomileusis (LASIK). These procedures are the two most common laser surgical refractive methods. In Study I, myopic ophthalmic residents at Helsinki University Eye Hospital underwent a refractive correction by PRK. Five patients were followed up for 6 months to assess their subjective experience in hospital work and their performance in car driving simulator and in other visuomotor functions. Corneal morphological changes were assessed by in vivo confocal microscopy (ivCM). Study II comprised 14 patients who had undergone a PRK operation in 1993-1994. Visual acuity was examined and ivCM examinations performed 5 years postoperatively. In Study III 15 patients received LASIK refractive correction for moderate to high myopia (-6 - -12 D). Their corneal recovery was followed by ivCM for 2 years. Diffuse lamellar keratitis (DLK) is a common but variable complication of LASIK. Yet, its aetiology remains unknown. In Study IV we examined six patients who had developed DLK as a consequence of formation of an intraoperative or post-LASIK epithelial defect, to assess the corneal and conjunctival inflammatory reaction. In the whole series, the mean refractive correction was -6.46 diopters. The best spectacle corrected visual acuity (BSCVA) improved in 30 % of patients, whereas in four patients BSCVA decreased slightly. The mean achieved refraction was 0.35 D undercorrected. After PRK, the stromal scar formation was highest at 2 to 3 months postoperatively and subsequently decreased. At 5 years increased reflectivity in the subepithelial stroma was observed in all patients. Interestingly, no Bowman s layer was detected in any patient. Subbasal nerve fiber bundle(snfb) regeneration could be observed already at 2 months in 2 patients after PRK. After 5 years, all corneas presented with snfb, the density of which, however, was still lower than in control corneas. LASIK induced a hypocellular area on both sides of the flap interface. A decrease of the most anterior keratocyte density was also observed. In the corneas that developed DLK, inflammatory cell-type objects were present in the flap interface in half of the patients. The other patients presented only with keratocyte activation and highly reflective extracellular matrix. These changes resolved completely with medication and time. Snfb regeneration was first detected at one month post-LASIK, but still after two years the density of snfb, however, was only 64 % of the preoperative values. The performance of ophthalmological examinations and microsurgery without spectacles was easier postoperatively, which was appreciated by the residents. Both PRK and LASIK showed moderate to good accuracy and high safety. In terms of visual perception and subjective evaluation, few patients stated any complaints in the whole series of studies. Instead, the majority of patients experienced a marked improvement in everyday life and work performance. PRK and LASIK have shown similar results, with good long term morphological healing. It seems evident that, even without the benefit of over-20-year follow-up results, these procedures are sufficiently safe and accurate for refractive corrections and corneal reshaping.

Si, CdTe and CdZnTe radiation detectors for imaging applications

The structure and operation of CdTe, CdZnTe and Si pixel detectors based on crystalline semiconductors, bump bonding and CMOS technology and developed mainly at Oy Simage Ltd. And Oy Ajat Ltd., Finland for X- and gamma ray imaging are presented. This detector technology evolved from the development of Si strip detectors at the Finnish Research Institute for High Energy Physics (SEFT) which later merged with other physics research units to form the Helsinki Institute of Physics (HIP). General issues of X-ray imaging such as the benefits of the method of direct conversion of X-rays to signal charge in comparison to the indirect method and the pros and cons of photon counting vs. charge integration are discussed. A novel design of Si and CdTe pixel detectors and the analysis of their imaging performance in terms of SNR, MTF, DQE and dynamic range are presented in detail. The analysis shows that directly converting crystalline semiconductor pixel detectors operated in the charge integration mode can be used in X-ray imaging very close to the theoretical performance limits in terms of efficiency and resolution. Examples of the application of the developed imaging technology to dental intra oral and panoramic and to real time X-ray imaging are given. A CdTe photon counting gamma imager is introduced. A physical model to calculate the photo peak efficiency of photon counting CdTe pixel detectors is developed and described in detail. Simulation results indicates that the charge sharing phenomenon due to diffusion of signal charge carriers limits the pixel size of photon counting detectors to about 250 μm. Radiation hardness issues related to gamma and X-ray imaging detectors are discussed.

Kerjääminen ja kaupustelu kielletty. Kerjäämisen vastustaminen Helsingissä 1930-luvun laman aikana ja kontrollin diskurssit.

Opinnäytetyössäni tarkastelen kerjuun kontrollin muotoja Helsingissä 1930-luvun laman aikana. Kontrollitoimenpiteiden lisäksi tutkin kerjuun määrittelemistä ongelmaksi ja ilmiön tuomitsemista. Poimin moniäänisestä diskurssista keskeisiä argumentteja, jotka määrittivät kerjäämistä ja sen kitkemiseksi valittuja keinoja. Diskursseja analysoimalla pyrin paljastamaan sosiaalisiin ongelmiin ja poikkeavuuden kontrolloimiseen liittyneitä pyrkimyksiä ja valtarakenteita. 1930-luvun lama saattoi Suomessa kymmenet tuhannet henkilöt työttömiksi ja köyhäinhoidon varaan. Köyhäinhoidossa ja irtolaishuollossa työnteon rooli oli ensisijainen ja tilannetta pyrittiin lievittämään varatyöjärjestelmin. Kerjuu oli tarkasteluajanjaksolla kielletty vuoden 1879 vaivaishoitoasetuksella. Kerjuu kuitenkin lisääntyi huomattavasti. Maanteillä liikkuvat kulkurit ja ovilla pyytävät kerjäläiset herättivät virkamiesten, papiston ja kansalaisten huomion ja köyhyydestä tuli paitsi sosiaalinen, myös hyvin poliittinen ongelma. Helsingissä poliisi pidätti pahimpina aikoina yhdeksän kertaa enemmän kerjäläisiä kuin normaaliaikana. Useimmiten pidätetyt lähetettiin kotipaikkakunnalleen, heille annettiin köyhäinhoitoviranomaisten varoitus tai heidät alistettiin maaherran kuulusteluihin. Kerjäämisestä myös tuomittiin yleiseen pakkotyöhön. Seurakunnat ryhtyivät valtion työttömyyskomitean sihteerin pyynnöstä organisoimaan pula-ajan avustustoimenpiteitä ja vastustamaan kerjuuta Helsingissä. Vuonna 1931 perustettiin Diakoniakeskus johtamaan tätä työtä. Propagandallaan Diakoniakeskus pyrki lopettamaan almujen antamisen ovilla, keskittämään avustustoimintaa ja saamaan myös yleisöstä kannattavia jäseniä toiminnalleen. Diakoniakeskuksen toiminta perustui hätäapuaseman ja yösuojan ylläpitämiseen ja se asettui yhteistyöhön myös köyhäinhoitoviranomaisten kanssa. Vallitsevissa diskursseissa kerjääminen esitettiin paheksuttavana ja demoralisoivana toimintana ja sen katsottiin kulkevan käsi kädessä valehtelemisen ja rikollisuuden kanssa. Myös viittaukset nälkävuosiin ja sisällissotaan nousivat esiin viranomaisten esittämissä vaatimuksissa kerjäämisen hillitsemiseksi. Diskursseista ja toiminnasta paljastui voimakkaita kerjäläisten seulomiseen ja laitostamiseen tähdänneitä pyrkimyksiä. Sopeutumattomiksi määritellyt yksilöt tuli alistaa holhouksen ja kontrollin alaisiksi, ja heidät tuli siivota arkipäivän yhteiskunnasta jopa pakkotyölaitoksiin. Diakoniakeskus, viranomaiset ja yleisö olivat kaikki osapuolia siinä kerjuun yhteiskunnalle vahingollisena määrittelevässä diskurssissa, joka heijasteli myös ajan henkeä. Diskursseista nousevatkin esiin ajan hengen mukaiset medikalisoituneen moralismin diskurssit sekä vallanpitäjien moraalinen paniikki köyhyyden äärellä. Vuonna 1937 astuivat voimaan uudet huoltolait, jolloin kerjääminen muuttui köyhäinhoidollisesta kysymyksestä järjestyskysymykseksi ja osaksi irtolaisuutta. Kerjuun vähetessä myös Diakoniakeskuksen toiminnan kannattavuus väheni ja se siirsikin propagandansa painopistettä pois kerjäämisen vastustamisesta. Tutkielman lopussa tarkastelen vielä lyhyesti 2000-luvun romanikerjäläisdiskurssia ja sen yhteneväisyyksiä 1930-luvun keskusteluun ja toimenpiteisiin. Keskeisen lähdeaineiston tutkielmalle muodostavat Helsingin seurakuntayhtymän arkistossa säilytettävät Diakoniakeskuksen lentolehtiset, pöytäkirjat, kirjeet ja lehtileikekokoelma, virallisjulkaisut sekä Huoltaja- ja Poliisimies-lehdissä sekä Suomen Kuvalehdessä julkaistu aikalaiskirjallisuus. Muun lähdeaineiston hankkimisessa olen käyttänyt aineistoja huoltoviraston arkistosta, Helsingin poliisilaitoksen arkistosta sekä Helsingin yliopiston kirjaston käsikirjoituskokoelmista.

Functional Surfaces for Microfluidics in Proteomic Analysis

Microchips for use in biomolecular analysis show a lot of promise for medical diagnostics and biomedical basic research. Among the potential advantages are more sensitive and faster analyses as well as reduced cost and sample consumption. Due to scaling laws, the surface are to volume ratios of microfluidic chips is very high. Because of this, tailoring the surface properties and surface functionalization are very important technical issues for microchip development. This thesis studies two different types of functional surfaces, surfaces for open surface capillary microfluidics and surfaces for surface assisted laser desorption ionization mass spectrometry, and combinations thereof. Open surface capillary microfluidics can be used to transport and control liquid samples on easily accessible open surfaces simply based on surface forces, without any connections to pumps or electrical power sources. Capillary filling of open partially wetting grooves is shown to be possible with certain geometries, aspect ratios and contact angles, and a theoretical model is developed to identify complete channel filling domains, as well as partial filling domains. On the other hand, partially wetting surfaces with triangular microstructures can be used for achieving directional wetting, where the water droplets do not spread isotropically, but instead only spread to a predetermined sector. Furthermore, by patterning completely wetting and superhydrophobic areas on the same surface, complex droplet shapes are achieved, as the water stretches to make contact with the wetting surface, but does not enter into the superhydrophobic domains. Surfaces for surface assisted laser desorption ionization mass spectrometry are developed by applying various active thin film coatings on multiple substrates, in order to separate surface and bulk effects. Clear differences are observed between both surface and substrate layers. The best performance surfaces consisted of amorphous silicon coating and an inorganic-organic hybrid substrate, with nanopillars and nanopores. These surfaces are used for matrix-free ionization of drugs, peptides and proteins, and for some analytes, the detection limits were in the high attomoles. Microfluidics and laser desorption ionization surfaces are combined on a functionalized drying platforms, where the surface is used to control the shape of the deposited analyte droplet, and the shape of the initial analyte droplet affects the dried droplet solute deposition pattern. The deposited droplets can then directly detected by mass spectrometry. Utilizing this approach, results of analyte concentration, splitting and separation are demonstrated.

Hila- ja kuviotason laskennan vaikutus kuvion kokonaistilavuuteen, tallennustilaan ja laskentaaikaan teoreettista läpimittajakaumaa ja runkolukusarjaa käyttämällä

Metsäsuunnittelussa tarvittavan metsävaratiedon keräämisessä ollaan Suomessa siirtymässä kuvioittaisesta arvioinnista laserkeilaus- ja ilmakuvapohjaiseen kaukokartoitukseen. Tämän tutkimuksen tarkoitus oli selvittää kuvion kokonaistilavuuden ja läpimittajakauman ennustamisen tarkkuus koealan metsikkö- ja puustotunnuksista MSN-, PRM-, ML- ja FMM-menetelmiä sekä Weibull-jakaumaa hyödyntäen seuraavilla tavoilla: 1. PRM-menetelmällä hilatasolla, 2. PRMmenetelmällä kuviotasolla, 3. ML-menetelmällä hilatasolla ja 4. ML-menetelmällä kuviotasolla. Lisäksi kuvion kokonaistilavuuden ennustamisen tarkkuus selvitettiin hyödyntäen kuviolle tuotettua runkolukusarjaa. Tulokset laskettiin puulajikohtaisesti männylle, kuuselle, koivulle ja muille puulajeille. Puulajien tulokset laskettiin kuviotasolla yhteen. Lisäksi selvitettiin menetelmien laskenta-ajan ja tallennustilan tarve. Tutkimuksen aineistona käytettiin Hämeen ammattikorkeakoulun Evon toimipisteen metsistä mitattuja kiinteäsäteisiä ympyräkoealoja, joita oli 249 kappaletta. Hakkuukoneella mitattiin 12kuvion, joiden pinta-alat vaihtelivat välillä 0,2 – 1,94 hehtaaria, puustotiedot. Aluepohjaisen laserkeilausaineiston pulssin tiheys oli 1,8/m2 ja ilmakuvien pikselikoko 0,5 metriä. Kuvion kokonaistilavuus ennustettiin tai estimoitiin laserkeilaus- ja ilmakuva-aineiston piirteiden avulla koealojen puustotunnuksista. Tulokset laskettiin erikseen kaikille kuvioille ja kuvioille, joiden pinta-ala oli yli 0,5 hehtaaria. Yli 0,5 hehtaarin kuvioita oli 8 kappaletta. Kuvion hilojen naapureina käytettiin 1 - 10 koealaa. Menetelmästä ja naapurien määrästä riippuen kokonaistilavuuden suhteellinen RMSE ja harha vaihtelivat välillä 20,76 – 52,86 prosenttia ja -12,04 – 46,54 prosenttia. Vastaavat luvut yli 0,5 hehtaarin kuvioilla olivat 6,74 – 59,41 prosenttia ja -8,04 – 49,59 prosenttia. Laskenta-aika vaihteli menetelmien ja käytettyjen naapurien määrän mukaan voimakkaasti. Kehittyneemmällä ohjelmoinnilla ja ohjelmistolla laskenta-ajat voivat laskea merkittävästi. Tallennustila ei testatuilla menetelmillä ole rajoittava tekijä laajassakaan mittakaavassa. Läpimittajakauman perusteella PRM-menetelmä ennustaa puulajille erittäin kapean läpimittajakauman, jos koeala koostuu vain muutamasta lähes samankokoisesta puusta. Tämä vaikutti tuloksiin erityisesti menetelmällä PRM2.

Associations of interleukin-1 (IL-1) gene variation and IL-1 receptor antagonist phenotypes with immunological responses, metabolic dysregulation and type 2 diabetes

The upstream proinflammatory interleukin-1 (IL-1) cytokines, together with a naturally occurring IL-1 receptor antagonist (IL-1Ra), play a significant role in several diseases and physiologic conditions. The IL-1 proteins affect glucose homeostasis at multiple levels contributing to vascular injuries and metabolic dysregulations that precede diabetes. An association between IL-1 gene variations and IL-1Ra levels has been suggested, and genetic studies have reported associations with metabolic dysregulation and altered inflammatory responses. The principal aims of this study were to: 1) examine the associations of IL-1 gene variation and IL-1Ra expression in the development and persistence of thyroid antibodies in subacute thyroiditis; 2) investigate the associations of common variants in the IL-1 gene family with plasma glucose and insulin concentrations, glucose homeostasis measures and prevalent diabetes in a representative population sample; 3) investigate genetic and non-genetic determinants of IL-1Ra phenotypes in a cross-sectional setting in three independent study populations; 4) investigate in a prospective setting (a) whether variants of the IL-1 gene family are predictors for clinically incident diabetes in two population-based observational cohort studies; and (b) whether the IL-1Ra levels predict the progression of metabolic syndrome to overt diabetes during the median follow-up of 10.8 and 7.1 years. Results from on patients with subacte thyroiditis showed that the systemic IL-1Ra levels are elevated during a specific proinflammatory response and they correlated with C-reactive protein (CRP) levels. Genetic variation in the IL-1 family seemed to have an association with the appearance of thyroid peroxidase antibodies and persisting local autoimmune responses during the follow-up. Analysis of patients suffering from diabetes and metabolic traits suggested that genetic IL-1 variation and IL-1Ra play a role in glucose homeostasis and in the development of type 2 diabetes. The coding IL-1 beta SNP rs1143634 was associated with traits related to insulin resistance in cross-sectional analyses. Two haplotype variants of the IL-1 beta gene were associated with prevalent diabetes or incident diabetes in a prospective setting and both of these haplotypes were tagged by rs1143634. Three variants of the IL-1Ra gene and one of the IL-1 beta gene were consistently identified as significant, independent determinants of the IL-1Ra phenotype in two or three populations. The proportion of the phenotypic variation explained by the genetic factors was modest however, while obesity and other metabolic traits explained a larger part. Body mass index was the strongest predictor of systemic IL-1Ra concentration overall. Furthermore, the age-adjusted IL-1Ra concentrations were elevated in individuals with metabolic syndrome or diabetes when compared to those free of metabolic dysregulation. In prospective analyses the systemic IL-1Ra levels were found as independent predictors for the development of diabetes in people with metabolic syndrome even after adjustment for multiple other factors, including plasma glucose and CRP levels. The predictive power of IL-1Ra was better than that of CRP. The prospective results also provided some evidence for a role of common IL-1 alpha promoter SNP rs1800587 in the development of type 2 diabetes among men and suggested that the role may be gender specific. Likewise, common variations in the IL-1 beta coding region may have a gender specific association with diabetes development. Further research on the potential benefits of IL-1Ra measurements in identifying individuals at high risk for diabetes, who then could be targeted for specific treatment interventions, is warranted. It has been reported in the recent literature that IL-1Ra secreted from adipose tissue has beneficial effects on glucose homeostasis. Furthermore, treatment with recombinant human IL-1Ra has been shown to have a substantial therapeutic potential. The genetic results from the prospective analyses performed in this study remain inconclusive, but together with the cross-sectional analyses they suggest gender-specific effects of the IL-1 variants on the risk of diabetes. Larger studies with more extensive genotyping and resequencing may help to pinpoint the exact variants responsible and to further elucidate the biological mechanisms for the observed associations. This would improve our understanding of the pathways linking inflammation and obesity with glucose and insulin metabolism.

Matalan syntyvyyden syitä ja seurauksia julkisen eläkejärjestelmän ylläpidon ja uudistamisen näkökulmasta

Viime vuosikymmeninä teollistuneissa OECD-maissa yksi suurimmista väestöllisistä muutoksista on tapahtunut syntyvyydessä. Sotien jälkeen syntyneiden suurten ikäluokkien jälkeen useissa teollistuneissa maissa väestönkasvun trendi on ollut laskeva, mikä puolestaan on johtanut kasvavaan huoleen matalan syntyvyyden sosioekonomisista seurauksista. Matala syntyvyyden taso on monissa kehittyneissä maissa luonut varjon valtion ylläpitämän sosiaaliturvajärjestelmän ylle ja sen rahoituspohjan heikentyminen on kasvattanut huolta järjestelmän tulevaisuudesta. Myös muun muassa viime vuosikymmenten taloudelliset taantuma-ajat, väestön ikärakenteessa ja työmarkkinoilla tapahtuneet muutokset, sekä väestön ikääntyminen ja veronmaksajien väheneminen ovat luoneet uudenlaiset paineet julkisen sosiaaliturva- ja eläkejärjestelmän ylläpidolle ja rahoittamiselle. Mietittäessä puolestaan syitä syntyvyyden madaltumiseen viime vuosikymmeninä, ovat tutkimukset osoittaneet, etteivät talous- ja sosiaalijärjestelmien rakenne sekä niissä tapahtuneet muutokset ole olleet tässä muutoksessa merkityksettömiä. Verotuksella ja valtion myöntämillä sosiaalituilla on osoitettu olevan vaikutus yksilön lapsenhankinta- ja myös perheenmuodostamispäätökseen. Tässä tutkielmassa tutkimuksen kohteena ovat matala syntyvyys, sekä sen syyt ja seuraukset taloustieteellisestä näkökulmasta. Tutkielman tarkoituksena on selvittää matalan syntyvyyden ja perheen perustamisen sekä jakojärjestelmäisen eläkejärjestelmän välistä yhteyttä, ja löytää todisteita siitä, millaisia kannustimia julkisella eläkejärjestelmällä syntyvyyden suhteen on. Li-säksi tutkielmassa perehdytään julkisen eläkejärjestelmän tulevaisuuteen väestöllisten haastei-den edessä, ja tarkastellaan järjestelmän uudistamismahdollisuuksia. Matalaa syntyvyyttä tarkastellaan muun muassa väestöllisen transition teorian avulla. Matalan syntyvyyden ja jakojärjestelmäisen eläkejärjestelmän suhdetta tutkitaan Zhangin ja Zhangin (2007) matemaattisella mallinnuksella, jonka avulla saadaan selville, että julkisen eläkejärjes-telmän käyttö sosiaalisen hyvinvoinnin optimoinnissa on pääomainvestointien ulkoisvaikutusten myötä oikeutettua, ja että järjestelmällä ja sitä rahoittavalla tuloverolla on negatiivinen vaikutus syntyvyyteen, mikäli vanhemmat preferoivat lastensa laadullisia, hyvinvointiin liittyviä ominai-suuksia niiden lukumäärään. Perheen perustamisen ja eläkejärjestelmän suhdetta puolestaan tarkastellaan Ehrlichin ja Kimin (2007) tutkimuksen pohjalta. Ehrlichin ja Kimin tutkimuksen tulos on, että julkista eläkejärjestel-mää rahoittavan tuloveron ja sen korottamisen vaikutus syntyvyyteen ja perheen perustamiseen on negatiivinen. Julkisen eläkejärjestelmän viittä eri uudistamisvaihtoehtoa ja niiden hyvinvointi-vaikutuksia käsitellään tutkielmassa pääosin Attanasion, Kitaon ja Violanten (2007) mallin avul-la. Jokaisella reformilla on Attanasion, Kitaon ja Violanten mukaan erilaisia makrotaloudellisia vaikutuksia, joita tarkastellaan tutkielmassa pääosin sanallisesti ja graafisesti, sekä eri tutkimus-ten tuloksia vertailemalla. Tutkielmassa käsite syntyvyys rinnastetaan taloustieteellisessä mielessä lasten kysynnäksi, ja sitä tutkitaan pääosin makrotaloudellisesta näkökulmasta. Kaikki tutkielmassa käytettävät matemaattiset mallit ovat limittäisten sukupolvien malleja ja julkisella eläkejärjestelmällä viitataan jakojärjestelmäiseen, pay-as-you-go -eläkejärjestelmään.

Texts "Con and Pro" : The Early Modern Medical Controversy over Tobacco

The habit of "drinking smoke" , meaning tobacco smoking, caused a true controversy in early modern England. The new substance was used both for its alleged therapeutic properties as well as its narcotic effects. The dispute over tobacco continues the line of written controversies which were an important means of communication in the sixteenth and seventeenth century Europe. The tobacco controversy is special among medical controversies because the recreational use of tobacco soon spread and outweighed its medicinal use, ultimately causing a social and cultural crisis in England. This study examines how language is used in polemic discourse and argumentation. The material consists of medical texts arguing for and against tobacco in early modern England. The texts were compiled into an electronic corpus of tobacco texts (1577 1670) representing different genres and styles of writing. With the help of the corpus, the tobacco controversy is described and analyzed in the context of early modern medicine. A variety of methods suitable for the study of conflict discourse were used to assess internal and external text variation. The linguistic features examined include personal pronouns, intertextuality, structural components, and statistically derived keywords. A common thread in the work is persuasive language use manifested, for example, in the form of emotive adjectives and the generic use of pronouns; the latter is especially pronounced in the dichotomy between us and them. Controversies have not been studied in this manner before but the methods applied have supplemented each other and proven their suitability in the study of conflictive discourse. These methods can also be applied to present-day materials.

Traditionally Protected Forests´ Role within Transforming Natural Resource Management Regimes in Taita Hills, Kenya

In Taita Hills, south-eastern Kenya, remnants of indigenous mountain rainforests play a crucial role as water towers and socio-cultural sites. They are pressurized due to poverty, shortage of cultivable land and the fading of traditional knowledge. This study examines the traditional ecological knowledge of Taitas and the ways it may be applied within transforming natural resource management regimes. I have analyzed some justifications for and hindrances to ethnodevelopment and participatory forest management in light of recently renewed Kenyan forest policies. Mixed methods were applied by combining an ethnographic approach with participatory GIS. I learned about traditionally protected forests and their ecological and cultural status through a seek out the expert method and with remote sensing data and tools. My informants were: 107 household interviewees, 257 focus group participants, 73 key informants and 87 common informants in participatory mapping. Religious leaders and state officials shared their knowledge for this study. I have gained a better understanding of the traditionally protected forests and sites through examining their ecological characteristics and relation to social dynamics, by evaluating their strengths and hindrances as sites for conservation of cultural and biological diversity. My results show that, these sites are important components of a complex socio-ecological system, which has symbolical status and sacred and mystical elements within it, that contributes to the connectivity of remnant forests in the agroforestry dominated landscape. Altogether, 255 plant species and 220 uses were recognized by the tradition experts, whereas 161 species with 108 beneficial uses were listed by farmers. Out of the traditionally protected forests studied 47 % were on private land and 23% on community land, leaving 9% within state forest reserves. A paradigm shift in conservation is needed; the conservation area approach is not functional for private lands or areas trusted upon communities. The role of traditionally protected forests in community-based forest management is, however, paradoxal, since communal approaches suggests equal participation of people, whereas management of these sites has traditionally been the duty of solely accredited experts in the village. As modernization has gathered pace such experts have become fewer. Sacredness clearly contributes but, it does not equal conservation. Various social, political and economic arrangements further affect the integrity of traditionally protected forests and sites, control of witchcraft being one of them. My results suggest that the Taita have a rich traditional ecological knowledge base, which should be more determinately integrated into the natural resource management planning processes.