Zubiri y Ellacuría: fundamentos filosóficos para una teoría estructural y una praxeología crítica de las relaciones internacionales

La hipótesis de partida de esta tesis es que la teoría de las Relaciones Internacionales (RRII) se encuentra ante un problema de carácter filosófico que impide su adecuada fundamentación. El objeto mismo de la teoría de las RRII ha sido foco de numerosas disputas a lo largo y ancho de los debates con que la disciplina ha explicado sus diversos posicionamientos y enfoques. De igual manera, diferentes aproximaciones metodológicas han ido evolucionando al albur de los avances que la Filosofía de la Ciencia venía incorporando. Así, los diversos puntos de vista han tratado de adaptarse a las novedades de carácter epistemológico que incorporaba la Teoría de la Ciencia en forma de nuevos paradigmas y programas de investigación sin detenerse lo suficiente en revisar los postulados sustanciales sobre los que partió y se desarrollaron las distintas teorizaciones. Con demasiada frecuencia, los conceptos que guiaron los esfuerzos de la revisión de dichos postulados fueron utilizados de forma superficial, tratando con ello más bien de sustentar las teorías pre-configuradas que de realizar una aproximación reflexiva a la realidad sobre la que se pretendía teorizar, lo que ha evidenciado una insuficiencia conceptual de la teoría de las RRII para hacer frente a la realidad (Ashley 1984; Bohman 2009; Cox y Schechter 2002; Jackson 2008; Lapid 2003; Monteiro y Ruby 2009; Walker 1993)...

Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock

UNLABELLED Since its discovery in the early 2000s, methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) has become a rapidly emerging cause of human infections, most often associated with livestock exposure. We applied whole-genome sequence typing to characterize a diverse collection of CC398 isolates (n = 89), including MRSA and methicillin-susceptible S. aureus (MSSA) from animals and humans spanning 19 countries and four continents. We identified 4,238 single nucleotide polymorphisms (SNPs) among the 89 core genomes. Minimal homoplasy (consistency index = 0.9591) was detected among parsimony-informative SNPs, allowing for the generation of a highly accurate phylogenetic reconstruction of the CC398 clonal lineage. Phylogenetic analyses revealed that MSSA from humans formed the most ancestral clades. The most derived lineages were composed predominantly of livestock-associated MRSA possessing three different staphylococcal cassette chromosome mec element (SCCmec) types (IV, V, and VII-like) including nine subtypes. The human-associated isolates from the basal clades carried phages encoding human innate immune modulators that were largely missing among the livestock-associated isolates. Our results strongly suggest that livestock-associated MRSA CC398 originated in humans as MSSA. The lineage appears to have undergone a rapid radiation in conjunction with the jump from humans to livestock, where it subsequently acquired tetracycline and methicillin resistance. Further analyses are required to estimate the number of independent genetic events leading to the methicillin-resistant sublineages, but the diversity of SCCmec subtypes is suggestive of strong and diverse antimicrobial selection associated with food animal production. IMPORTANCE Modern food animal production is characterized by densely concentrated animals and routine antibiotic use, which may facilitate the emergence of novel antibiotic-resistant zoonotic pathogens. Our findings strongly support the idea that livestock-associated MRSA CC398 originated as MSSA in humans. The jump of CC398 from humans to livestock was accompanied by the loss of phage-carried human virulence genes, which likely attenuated its zoonotic potential, but it was also accompanied by the acquisition of tetracycline and methicillin resistance. Our findings exemplify a bidirectional zoonotic exchange and underscore the potential public health risks of widespread antibiotic use in food animal production.