243 resultados para compound 48-80

em Chinese Academy of Sciences Institutional Repositories Grid Portal


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白垩纪末至第三纪初(K/T界限,距今约65Ma),恐龙大规模灭绝,爬行类的优势地位被哺乳动物所取代;裸子植物和蕨类急剧衰退,被子植物蓬勃发展,并逐渐成为地表植被的主体,研究这一时期的植物群的结构和特征进而揭示植物演化和环境变迁的规律及其相互关系是当今地球科学、生命科学和环境科学的重要研究内容。黑龙江省嘉荫地区的乌云组产有丰富的植物化石,其地质时代虽未定论,但不超出晚白垩世马斯特里赫特期至早第三纪古新世的范围,处于K/T界限,对其植物群的研究意义重大。乌云植物群以往的研究在古果实学研究方面明显不足、在植物群的性质的认识及乌云组时代的确定等方面存在很大争议。本文重点研究了乌云组的果实和种子化石,增添了新的植物类群,丰富了此植物群的研究内容,对乌云组的时代问题的确定提供了新的证据。 本文研究了乌云组的Nordenskioldia borealis(昆兰树科)、Nyssidium jianyinense sp. nov. (连香树科)、Hypericum zhuii sp. nov. (金丝桃科)、Amersinia obtrullate(广义山茱萸科)、Acer wuyunense sp. nov.(槭树科)等5种果实和种子化石。Nordenskioldia borealis的果无柄、为分果、小果瓣环绕中央柱轮状排列。Nyssidium jianyinense的果序为圆锥果序、蓇葖对生、蓇葖腹缝相对、果皮三层。Hypericum zhuii的种子外形呈长椭圆形、端部具乳突、表面网状、种脊明显、种皮两层、外种皮细胞的垂周壁明显加厚。Amersinia obtrullate果序头状、果镘形、3果室。Acer wuyunense果为翅果、小坚果被明显侧翼、翅强烈下延,包围小坚果。经修订和补充,乌云植物群目前共有维管植物48属60种,其中,蕨类植物4属6种、裸子植物7属7种、被子植物37属48种,被子植物占总种数的80%、占总属数的77%,被子植物占绝对优势。当时的群落类型湿生群落和中生群落类型为主,湿生群落主要有:由Sequoia、Metasequoia、Taxodium、Glyptostrobus等组成的针叶林;以Nyssidium、Trochodendroides占优势的阔叶林。 以Metasequoia占优势的针叶林和以Nyssidium、Trochodendroides等占优势的阔叶林。乌云植物群中热带和亚热带成分占种子植物总属数的54%,而温带成分则占36%,亚热带成分占优势,当时的气候-植被类型为亚热带常绿林或常绿夏绿混交林。Nordenskioldia、Nyssidium、Amersinia、Acer化石的地质分布不早于古新世的地层,这—证据不支持乌云组的地质时代划为晚白垩世,而支持划归古新世的观点。

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The aim of the present Study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, adrenalectomized (ADX) and implanted with a cholesterol pellet, ADX and implanted with a 10 mg CORT pellet, or ADX and 50 mg, of CORT. Different CORT levels or doses of nicotine did not significantly affect startle responses. Baseline PPI was significantly reduced in mice implanted with the highest dose of CORT. In ADX mice implanted with cholesterol, nicotine treatment influenced PPI depending on the prepulse intensity. In ADX mice implanted with 50 mg of CORT, treatment with 10 mg/kg of nicotine caused a significant increase in PPI at all prepulse intensities. Binding studies showed that corticosterone treatment had significantly affected nicotinic acetylcholine receptor (nAChR) density in the mouse brain. Treatment with 50 mg CORT decreased I-125-epibatidine binding in the globus pallidus and I-125-alpha-bungarotoxin binding in the claustrum. These results suggest a possible interaction of corticosterone and nicotine at the level of the alpha4- and alpha7-type nAChR in the regulation of PPI. In situations of high circulating levels of corticosterone, nicotine may be beneficial to restore disruption of PPI. (C) 2004 Elsevier Ltd. All rights reserved.

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对HIRFL浅层肿瘤治疗终端提供的碳离子束的物理特性进行了首次测量.结果显示,能量为80.55MeV/u的~(12)C离子束,其束流强度在0.001—0.1nA范围时,直径50mm照射野的均匀性为73.48%,束流强度在一段时间内的稳定性为80.87%.测得了束流在治疗装置等中心处的深度剂量分布,其高剂量的Bragg峰位处在13.866mm的水等效深度,反推出碳离子束在等中心处对应的能量为71.71MeV/u,与计算值基本吻合.对自由空气电离室的读数进行了吸收剂量的标定.测量结果显示,HIRFL浅层肿瘤治疗装置性能与临床治疗的要求相比稍有差距,为了达到治疗终端进行临床试验的要求,须对治癌装置性能做进一步的优化.

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根据天然草地退化程度的差异,采用松耙+补播+施肥+封育(退化较严重的草地)、封育+施肥(轻度退化草地)等措施,植物群落物种组成、多样性等特征值及其植被盖度发生明显变化.研究第2年结果表明,物种数封育+施肥处理最高(32种),对照居中(26种),补播+施肥处理最低(13种);多样性指数大小依次为封育+施肥(3.126)、对照(2.819)、补播+施肥(1.494);均匀度指数大小依次为封育+施肥(0.902)、对照(0.865)、补播+施肥(0.582);群落总盖度大小依次为封育+施肥(85.9%)、补播+施肥(79.7%)、对照(72.9%);补播+施肥+封育处理后地上生物量最大(460.65 g/m2),原生植被+封育+施肥处理居中(310.14 g/m2),对照最低(178.96 g/m2);地下生物量大小依次为封育+施肥(6 920.37 g/m2)、补播+施肥(1 458.96 g/m2)、对照(828.91 g/m2);补播+施肥+封育处理优良牧草较对照提高近50倍,杂草类减少82.81%,封育+施肥处理较对照良牧草比例提高48倍,杂草类比例减少80.46%.半人工草地通过灭除杂草和施肥相结合的示范试验表明:单纯进行灭杂,地上生物量减少,灭杂和施肥相结合不仅可提高地上生物量,而且可提高优良牧草的比例;不同处理区土壤养分含量各不相同,其中封育+施肥处理全氮、全碳、有机碳最高,对照居中,补播+施肥较低.

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由于目前抗HIV 药物价格昂贵且有较强的毒副作用,传统药物将成为未来 HIV 治疗的主流药物。许多植物来源的天然化合物体外具有较好的抗HIV 活性, 有些化合物甚至可以作用在病毒复制周期的不同阶段。HIV 侵入抑制剂目前成 为抗HIV 药物研发的热点。HIV 侵入抑制剂靶定在病毒复制周期的结合或融合 位点,对临床中已产生耐药性突变的病毒株也有较好的抑制作用。该类抑制剂 的出现将为HARRT 疗法提供更多新的药物组合。开发新一代的HIV-1 侵入抑制 剂,与逆转录酶或蛋白酶抑制剂联合使用将增加治疗的有效性并减少毒副作用 的产生。 灯盏花乙素(Scutellarin)与槐花化合物K3 均从天然植物资源中提取,且 前者在我国临床上一直有着广泛应用。我们对这两种化合物的抗HIV-1 活性进 行了研究,检测了其对实验室适应病毒株(HIV-1ⅢB)、耐药株(HIV-174V)和临 床分离病毒株(HIV-1KM018)的抑制活性。灯盏花乙素是从植物滇黄芩中分离出 来的具有多种生物活性的黄酮类化合物,该化合物抑制HIV-1ⅢB 诱导C8166 细 胞合胞体形成的EC50 为26μM,选择指数为36。灯盏花乙素对耐药病毒株和临 床分离株也表现出良好的抑制作用。从槐花中提取的硫酸酯类化合物K3 体外研 究证实也有很好的抗HIV-1 活性,它不仅可以抑制HIV-1 致细胞病变效应,也 可以抑制感染细胞中的HIV-1 特异性抗原表达,该化合物的半数有效抑制浓度 EC50 为5~54μM。 灯盏花乙素与槐花化合物K3 的抗HIV-1 机制研究结果表明:两种化合物均 能有效抑制病毒进入细胞。灯盏花乙素在54μM 时抑制45%的病毒粒子进入细 胞,槐花化合物K3 在40μM 时能够有效抑制56%的HIV-1 进入细胞;灯盏花乙 素与槐花化合物K3 也可以抑制C8166 细胞与慢性感染的H9/HIV-1ⅢB 细胞间的融合,灯盏花乙素的EC50 为15μM,而槐花化合物K3 的EC50 为5μM;两种化 合物对体外重组的HIV-1 逆转录酶有微弱的抑制作用,在433μM 时,灯盏花乙 素可以抑制48%的逆转录酶活性,槐花化合物K3 在300μM 时能够抑制80%的 HIV-1 逆转录酶活性;这两种化合物体外对HIV-1 均无直接杀伤作用,也不能抑 制慢性感染细胞中的病毒复制和HIV-1 蛋白酶活性。因此,灯盏花乙素与槐花 化合物K3 的体外抗HIV-1 作用机制主要源于其能够抑制HIV-1 RT 活性和阻止 HIV-1 进入细胞。 灯盏花乙素和槐花化合物K3的有效抗病毒活性和多种作用途径使其成为具 有发展潜力的抗病毒先导化合物。

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Within the framework of the dinuclear system (DNS) model, production cross sections of new superheavy nuclei with charged numbers Z=108-114 are analyzed systematically. Possible combinations based on the actinide nuclides U-238, Pu-244, and Cm-248,Cm-250 with the optimal excitation energies and evaporation channels are pointed out to synthesize new isotopes that lie between the nuclides produced in the cold fusion reactions and the Ca-48-induced fusion reactions experimentally, which are feasible to be constructed experimentally. It is found that the production cross sections of superheavy nuclei decrease drastically with the charged numbers of compound nuclei. Larger mass asymmetries of the entrance channels enhance the cross sections in 2n-5n channels.

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A new iron(III) coordination compound exhibiting a two-step spin-transition behavior with a remarkably wide [HS-LS] plateau of about 45 K has been synthesized from a hydrazino Schiff-base ligand with an N,N,O donor set, namely 2-methoxy-6-(pyridine-2-ylhydrazonomethyl) phenol (Hmph). The single-crystal X-ray structure of the coordination compound {[Fe(mph)(2)](ClO4)(MeOH)(0.5)(H2O)(0.5)}(2) (1) determined at 150 K reveals the presence of two slightly different iron(III) centers in pseudo-octahedral environments generated by two deprotonated tridentate mph ligands. The presence of hydrogen bonding interactions, instigated by the well-designed ligand, may justify the occurrence of the abrupt transitions. 1 has been characterized by temperature-dependent magnetic susceptibility measurements, EPR spectroscopy, differential scanning calorimetry, and Fe-51 Mossbauer spectroscopy, which all confirm the occurrence of a two-step transition. In addition, the iron(III) species in the high-spin state has been trapped and characterized by rapid cooling EPR studies.

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The crystal structures of EtEDTB.1.4C(2)H(5)OH.5H(2)O 1 and H4EtEDTB(ClO4)(4).C2H5OH 2 (EtEDTB = N, N,N',N'-tetrakis[2-(1-ethylbenzimidazolyl)methyl]-1,2-ethanediamine) have been determined by single-crystal X-ray diffraction method. Compound 1 crystallizes in the space group P(1) over bar with a = 11.489(2), b = 11.866(3), c = 12.002(3) Angstrom, alpha = 97.47(2), beta = 114.564(13), gamma = 114.11(2)degrees, V = 1266.6(5) Angstrom(3), Z = 1, M-r = 847.48, D-c = 1.111 g/cm(3), F(000) = 456 and mu(MoKalpha) = 0.076 mm(-1). A total of 5207 reflections were measured for 1, of which 4323 were independent. The structure of 1 was solved by direct methods and refined by full-matrix least-squares technique to the final R = 0.0706 and wR = 0.1802 for 1318 observed reflections with I > 2sigma(I). In the structure of 1, centrosymmetric EtEDTB molecules are linked by hydrogen bonds through water and ethanol to form 2-dimensional network. Compound 2 crystallizes in the space group C2/c with a = 24.260(5), b = 13.040(3), c = 17.680(4) Angstrom, beta = 97.50(3)degrees, V = 5545.2(2) Angstrom(3), Z = 4, M-r = 1140.80, D-c = 1.366 g/cm(3), F(000) = 2384 and mu(MoKalpha) = 0.289 mm(-1).

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Nanocrystalline intermetallic Co3Fe7 was produced on the surface of cobalt via surface mechanical attrition (SMA). Deformationinduced diffusion entailed the formation of a series of solid solutions. Phase transitions occurred depending on the atomic fraction of Fe in the surface solid solutions: from hexagonal close-packed (<4% Fe) to face-centered cubic (fcc) (4-11% Fe), and from fcc to body-centered cubic (>11% Fe). Nanoscale compositional probing suggested significantly higher Fe contents at grain boundaries and triple junctions than grain interiors. Short-circuit diffusion along grain boundaries and triple junctions dominate in the nanocrystalline intermetallic compound. Stacking faults contribute significantly to diffusion. Diffusion enhancement due to high-rate deformation in SMA was analyzed by regarding dislocations as solute-pumping channels, and the creation of excess vacancies. Non-equilibrium, atomic level alloying can then be ascribed to deformation-induced intermixing of constituent species. The formation mechanism of nanocrystalline intermetallic grains on the SMA surface can be thought of as a consequence of numerous nucleation events and limited growth. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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<正> 我国水能资源丰富,其特点是80%的水能蕴藏在深山峡谷的江河之中,水量充沛,落差集中,这是优点;但另一方面,深谷江河上谷窄山高,水深流急,交通不便,给用常规方法筑坝带来难以克服的困难。能否找到适合深谷

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本文对条带积分方法作进一步的简化,在给定各物理量剖面分布规律并补充以合理的尾迹边界发展规律后,将尾述在对称轴上所满足的守恒方程组作数值积分,计算了高超音速飞行器在零攻角飞行时的非平衡尾迹流场的流动参数和电子数密度的分布。考虑的情况为;半锥角11°的小钝头锥体,飞行速度7.6公里/秒,高程80、70、59、48公里四种,混合空气计及八种组元,14个化学反应关系式。 针对细长飞行器高超音速尾迹而言,本方法与多条带积分方法及差分方法相比具有处理简单,计算量小的优点,结果可以较好地给出沿尾迹轴上电子密度及其它物理量的变化情况。

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林同骥先生是我国著名流体力学家.在稀薄气体力学、高超声速、跨声速空气动力学和不可压缩流体动力学等广泛的领域中都有重要的研究成果,尤其是在再入飞行器防热、再人物体的表面烧蚀和不可压缩振荡流等方面,为我国航天事业和海洋工程的发展作出了贡献.林同骥先生在1979~1990年期间先后任《力学学报》副主编、主编.为《力学学报》在改革开放新形势下的发展和进人国际交流大网络倾注了大量心血.在纪念林同骥先生诞辰80周年之际,我们向读者介绍这位毕生献中华的科学家,并刊出他的学生们的一些论文,以表达怀念与崇敬之情.

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The surface mechanical attrition treatment (SMAT) technique was developed to synthesize a nanocrystalline (NC) layer on the surface of metallic materials for upgrading their overall properties and performance. In this paper, by means of SMAT to a pure zirconium plate at the room temperature, repetitive multidirectional peening of steel shots (composition (wt%): 1C, 1.5Cr, base Fe) severely deformed the surface layer. A NC surface layer consisting of the intermetallic compound FeCr was fabricated on the surface of the zirconium. The microstructure characterization of the surface layer was performed by using X-ray diffraction analysis, optical microscopy, scanning and transmission electron microscopy observations. The NC surface layer was about 25 mu m thick and consisted of the intermetallic compound FeCr with an average grain size of 25 +/- 10 nm. The deformation-induced fast diffusion of Fe and Cr from the steel shots into Zr occurred during SMAT, leading to the formation of intermetallic compound. In addition, the NC surface layer exhibited an ultrahigh nanohardness of 10.2 GPa.

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High-efficiency separation of the oil/gas/water mixtures is a significant issue in offshore oil industry. To reduce the total cost by means of reduction in weight and space compared with conventional separators, a novel compact compound oil/gas/water separator is developed. The research works on oil-gas-water separation by compound separating techniques is described in this paper. The innovative separator is a gravity settling tank with helical pipes within and T-shaped pipes outside. Both experiments and numerical simulations are presented to study the separating performance and efficiency of the helical pipes, which are the main part of the separator.

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