25 resultados para Wilms’ tumor, Wt1, tetracycline system, conditional mouse model, urogenital development
em Chinese Academy of Sciences Institutional Repositories Grid Portal
Resumo:
It is well known that noise and detection error can affect the performances of an adaptive optics (AO) system. Effects of noise and detection error on the phase compensation effectiveness in a dynamic AO system are investigated by means of a pure numerical simulation in this paper. A theoretical model for numerically simulating effects of noise and detection error in a static AO system and a corresponding computer program were presented in a previous article. A numerical simulation of effects of noise and detection error is combined with our previous numeral simulation of a dynamic AO system in this paper and a corresponding computer program has been compiled. Effects of detection error, readout noise and photon noise are included and investigated by a numerical simulation for finding the preferred working conditions and the best performances in a practical dynamic AO system. An approximate model is presented as well. Under many practical conditions such approximate model is a good alternative to the more accurate one. A simple algorithm which can be used for reducing the effect of noise is presented as well. When signal to noise ratio is very low, such method can be used to improve the performances of a dynamic AO system.
Resumo:
The growth behaviour of zero-mean-shear turbulent-mixed layer containing suspended solid particles has been studied experimentally and analysed theoretically in a two-layer fluid system. The potential model for estimating the turbulent entrainment rate of the mixed layer has also been suggested, including the results of the turbulent entrainment for pure two-layer fluid. The experimental results show that the entrainment behaviour of a mixed layer with the suspended particles is well described by the model. The relationship between the entrainment distance and the time, and the variation of the dimensionless entrainment rate E with the local Richardson number Ri1 for the suspended particles differ from that for the pure two-layer fluid by the factors-eta-1/5 and eta-1, respectively, where eta = 1 + sigma-0-DELTA-rho/DELTA-rho-0.
The Intelligent Measuring Sub-System in the Computer Integrated and Flexible Laser Processing System
Resumo:
Based on the computer integrated and flexible laser processing system, develop the intelligent measuring sub-system. A novel model has been built to compensate the deviations of the main frame, a new-developed 3-D laser tracker system is applied to adjust the accuracy of the system. Analyzing the characteristic of all kinds of automobile dies, which is the main processing object of the laser processing system, classify the types of the surface and border needed to be measured and be processed. According to different types of surface and border, develop 2-D adaptive measuring method based on B?zier curve and 3-D adaptive measuring method based on spline curve. During the data processing, a new 3-D probe compensation method has been described in details. Some measuring experiments and laser processing experiments are carried out to testify the methods. All the methods have been applied in the computer integrated and flexible laser processing system invented by the Institute of Mechanics, CAS.
Resumo:
The water-heat transfer process between land and atmosphere in Haibei alpine meadow area has been systematically observed. A multi-layer coupling model for land-atmosphere interaction was presented with special attention paid to the moisture transfer in leaf stomata under unsaturated condition. A profound investigation on the physical process of turbulent transfer inside the vegetation has been performed with a revised formula of water absorption for root system. The present model facilitates the study of vertically distributed physical variables in detail. Numerical simulation was conducted according to the transfer process of Kinesia humility meadow in the area of Haibei Alpine Meadow Ecosystem Station, CAS. The calculated results agree well with observation.
Resumo:
The present paper describes a systematic study of argon plasmas in a bell-jar inductively coupled plasma (ICP) source over the range of pressure 5-20 mtorr and power input 0.2-0.5 kW, Experimental measurements as well as results of numerical simulations are presented. The models used in the study include the well-known global balance model (or the global model) as well as a detailed two-dimensional (2-D) fluid model of the system, The global model is able to provide reasonably accurate values for the global electron temperature and plasma density, The 2-D model provides spatial distributions of various plasma parameters that make it possible to compare with data measured in the experiments, The experimental measurements were obtained using a tuned Langmuir double-probe technique to reduce the RF interference and obtain the light versus current (I-V) characteristics of the probe. Time-averaged electron temperature and plasma density were measured for various combinations of pressure and applied RF power, The predictions of the 2-D model were found to be in good qualitative agreement with measured data, It was found that the electron temperature distribution T-e was more or less uniform in the chamber, It was also seen that the electron temperature depends primarily on pressure, but is almost independent of the power input, except in the very low-pressure regime. The plasma density goes up almost linearly with the power input.
Resumo:
讨论了光学微分方法在图像深度估计问题中的应用。基于线性成像理论对Farid提出的光学微分模型进行了推广,即用于图像深度估计的两幅图像在成像过程中可以满足任意阶的线性微分关系。此模型拓宽了光学微分的概念,使两次成像之间关系有了更多的光学微分形式。围绕如何选择合适的光学微分关系以使系统的整体性能达到最优,分析了光学成像系统的参量对于图像深度估计的精度以及纵向分辨力的影响,并且对光学微分方法中的关键光学元件—光学掩模板的构建方法及优化问题也作了初步的探讨。
Resumo:
针对高功率激光装置四程放大系统的特点,利用矩阵光学原理,建立了四程放大准直系统的数学模型;基于此模型,设计了四程放大系统的准直调整方案;得出了近、远场偏移量与调整量关系的解析解.
Resumo:
多级安全数据库的安全策略需要各种模型来表达,访问控制模型是其中之一.强制访问控制(MAC)模型保证多级数据库中的信息流动符合系统的安全策略.利用基于角色的访问控制(RBAC)来实现MAC能方便多级安全数据库的权限管理.提出了一种MAC与RBAC的综合模型,定义了多级角色与内部角色的概念,并给出了综合模型中经过修改后的操作,使得系统能自动地完成符合强制访问控制策略的用户权限的管理.该模型方便了管理员的权限管理,适合用户较多,安全层次比较复杂的多级关系数据库系统.最后给出了模型的部分实现机制.
Resumo:
基于实时取证的思想,提出了一种安全可取证操作系统(security forensics operating system,简称SeFOS)的概念和实现思路.提出了其总体结构,建立了该系统的取证行为模型,对其取证服务和取证机制进行了分析并作了有关形式化描述,阐述了证据数据的采集和安全保护方法,提出把取证机制置于内核,基于进程、系统调用、内核资源分配和网络数据等获取证据的方法,并通过模拟实验验证了SeFOS的可取证性.可取证操作系统的研究对于进一步研究可取证数据库管理系统(forensic database management system,简称FDBMS)和可取证网络系统(forensic network,简称FNetWork)具有重要意义.
Resumo:
Using the isospin- and momentum-dependent hadronic transport model 1BUU04, we have investigated the influence of the entrance-channel isospin asymmetry on the sensitivity of the pre-equilibrium neutron/proton ratio to symmetry energy in central heavy-ion collisions induced by high-energy radioactive beams. Our analysis and discussion are based on the dynamical simulations of the three isotopic reaction Systems Sn-132+Sn-124, Sn-124+Sn-112 and Sn-112+(112)Su which are of the same total proton number but, different isospin asymmetry. We find that, the kinetic-energy distributions of the pre-equilibrium neutron/proton ratio are quite sensitive to the density-dependence of symmetry energy at incident beam energy E/A = 400 MeV, and the sensitivity increases as the isospin asymmetry of the reaction system increases.
Resumo:
目的:三价铬作为葡萄糖耐量因子的有效活性成分,具有改善糖尿病人的糖代谢和脂代谢的作用,因此补充三价铬是糖尿病治疗中的有效的营养措施,富铬酵母是目前向人体提供三价铬的有效途径,并且葡萄糖耐量因子可以提高靶组织对胰岛素的敏感性而不促进胰腺的胰岛素分泌,为治疗糖尿病提供了一种新方法。 方法:(1)取昆明种小鼠,分对照与实验组,适应性喂养后实验组小鼠按40mg/kg体重注射STZ,对照组注射相应体积柠檬酸缓冲液,连续注射5天,3天后测血糖值,取血糖值≥11.1mmol/L为成功模型。成模小鼠分为两组,一组灌胃富铬酵母悬液4周,另一组灌胃蒸馏水4周,测血糖值。(2)取昆明种小鼠,分对照与实验组,适应性喂养后实验组小鼠按200mg/kg体重注射STZ,对照组注射相应体积柠檬酸缓冲液,3d后测血糖,取血糖值≥11.1mmol/L为成功模型。成模小鼠分为两组,一组灌胃富铬酵母悬液4周,另一组灌胃蒸馏水4周,测血糖值。(3)取C57BL/6J断乳小鼠,随机分为正常饲料组和高脂饲料组,分别用相应饲料喂养3 周。高脂饲料组又分为高脂饲料对照组和高脂饲料实验组。第3 周末, 高脂饲料实验组腹腔内按100mg/kg体重一次性腹腔注射STZ;正常饲料组和高脂饲料对照组腹腔注射相应体积的无菌柠檬酸缓冲液。继续喂养4 周。小鼠以第7周末血糖为准,≥11.1mmol/L为成功模型。成模小鼠分为2组,1组每日灌胃富铬酵母悬液,另一组灌服相应体积的去离子水,4周后,测血糖值。 结果:对Ⅰ型糖尿病小鼠,富铬酵母治疗2周后,治疗组血糖明显低于对照组血糖(p<0.05),4周后显著低于(p<0.01);对Ⅱ型糖尿病小鼠,富铬酵母治疗2周后,治疗组血糖明显低于对照组血糖(p<0.05),3周后显著低于(p<0.01);对肥胖引起的Ⅱ型糖尿病小鼠,富铬酵母治疗2周后,治疗组血糖显 著低于对照组血糖(p<0.01),且血清胰岛素浓度之间没有明显差异。 结论:富铬酵母具有明显的降血糖作用,且不刺激胰岛素分泌
Resumo:
在分析薛家沟流域土地利用现状、持续利用条件和限制因素的基础上 ,依据流域立体分异特性 ,提出川平地以粮食种植、坡地以经济果木和防护林为主导的山地林果药菌立体开发的土地利用模式
Resumo:
Cyclic voltammetry was employed to study the influence of sterols on the lipophilic ion transport through the BLM. The mole fraction of the sterols (cholesterol, oxidized cholesterol). as referred to total lipid, was varied in a range of 0-0.8. Data demonstrate that a thin-layer model is suitable to this BLM system. By this model, the number of charges transported per lipophilic ion, the concentration of the ion in the membrane bulk phase and the aqueous/membrane phase partition coefficient could be calculated. These parameters proved that sterols had an obvious influence on the lipophilic ion transport. Cholesterol had a stronger influence on the ion transport than oxidized cholesterol. Its incorporation into egg lecithin membranes increased the partition coefficient beta of the ion up to more than 3-fold. Yet, oxidized cholesterol incorporated into egg lecithin membranes only increased the beta up to less than 2-fold, and the beta had no great variation at different oxidized cholesterol mole fractions. The higher beta obtained was partly due to the trace amount of solvent existing in the core of the lipid bilayers. At the different sterol mole fractions, combining the change of beta with the change of peak current, we also concluded that sterols had somewhat inhibiting effect on the ion transport at the higher sterols mole fraction (>0.4). These results are explained in terms of the possible change of dipole potential of the membrane produced by sterols and the decrease of the membrane fluidity caused by the condensation effect of sterols and the thinning effect caused by sterols. The substituting group (in the oxidized cholesterol) had some inhibiting effects on the ion transport at higher mole fractions (oxidized cholesterol mole fraction >0.4).
Resumo:
The high mortality rate of immunocompromised patients with fungal infections and the limited availability of highly efficacious and safe agents demand the development of new antifungal therapeutics. To rapidly discover such agents, we developed a high-throughput synergy screening (HTSS) strategy for novel microbial natural products. Specifically, a microbial natural product library was screened for hits that synergize the effect of a low dosage of ketoconazole (KTC) that alone shows little detectable fungicidal activity. Through screening of approximate to 20,000 microbial extracts, 12 hits were identified with broadspectrum antifungal activity. Seven of them showed little cytotoxicity against human hepatoma cells. Fractionation of the active extracts revealed beauvericin (BEA) as the most potent component, because it dramatically synergized KTC activity against diverse fungal pathogens by a checkerboard assay. Significantly, in our immunocompromised mouse model, combinations of BEA (0.5 mg/kg) and KTC (0.5 mg/kg) prolonged survival of the host infected with Candida parapsilosis and reduced fungal colony counts in animal organs including kidneys, lungs, and brains. Such an effect was not achieved even with the high dose of 50 mg/kg KTC. These data support synergism between BEA and KTC and thereby a prospective strategy for antifungal therapy.
Resumo:
Near-space, defined as the altitude region between 20 and 100 km, offers many capabilities that are not accessible for low Earth-orbit (LEO) satellites or airplanes because it is above storm and not constrained by orbital mechanics and high fuel consumption. Hence, a high flying speed can be obtained for the maneuvering vehicles operating in near-space. This offers a promising solution to simultaneous high-resolution and wide-swath synthetic aperture radar (SAR) imaging. As such, one near-space wide-swath SAR imaging technique is presented in this letter. The system configuration, signal model, and imaging scheme are described. An example near-space SAR system is designed, and its imaging performance is analyzed. Simulation results show that near-space maneuvering vehicle SAR indeed seems to be a promising solution to wide-swath SAR imaging.