郭永怀先生诞辰九十周年纪念文集

目录

High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China

The southeastern region of Yunnan province is a key site for drug trafficking and HIV-1 infection spread from the west of Yunnan and Laos to southeastern China. To investigate the prevalence of HIV-1 infection and hepatitis C virus (HCV) coinfection among injection drug users (IDUs) in southeastern Yunnan, three cohorts of 285 addicts, including 242 IDUs and 43 oral drug users, living in the cities of Gejiu and Kaiyuan and the county of Yanshan were studied. HIV-1 and HCV infections were detected by enzyme-linked immunosorbent assay and/or polymerase chain reaction. Data on the age, sex, risk behavior, drug use history, employment, ethnic background, and marriage status were obtained by interview. The overall prevalence of HIV-1 infection was 71.9%. The rate of HCV coinfection among 138 HIV-1-infected IDUs was 99.3%. Most HIV-infected IDUs were 20 to 35 years old (86.7%) and were ethnic Han (75.9%), suggesting that the epidemic in Yunnan is no longer confined to non-Han ethnic minorities, HIV prevalence in female IDUs (81.2%) was significantly higher than in male IDUs (68.2%) (p <.05). The prevalence of HIV infection reached 68.4% after 1 year of injection drug use. Needle/syringe sharing is the major high risk factor for the spread of HIV-1 and HCV infections. Large-scale educational campaigns are urgently needed to reduce the spread of HIV and HCV infection in these regions.

Insecticide resistance in Chinese populations of the Culex pipiens complex through esterase overproduction

In most parts of China, mosquitoes have been subjected to organophosphate (OP) insecticide treatments since the mid-1960s, and resistance gene monitoring in the Culex pipiens complex (Diptera: Culicidae) started in only a few locations from the end of the 1980s. Many resistant alleles at the Ester locus have been found in field populations, including those commonly found around the world (Ester(B1) and Ester(2)), and those endemic to China (Ester(B6), Ester(B7), Ester(8), and Ester(9)). This situation is atypical, and may represent a complex situation for the evolution of insecticide resistance genes in China. To increase our understanding of the Chinese situation and our ability to manage resistance in the C. pipiens complex, a large study was performed. Twenty field populations were sampled from Beijing to Guangzhou. Bioassays with five insecticides (dichlorvos, parathion, chlorpyrifos, 2-sec-butylphenyl methyl carbamate, and propoxur) disclosed resistance levels variable according to the geographic origin, and up to 85-fold for dichlorvos. Six overproduced esterases were identified, including two that have not been previously described. Most of them were found in all samples, although at variable frequencies, suggesting variable selection or a transient situation, e.g., each one was recently restricted to a particular geographic area. The results are discussed in the context of recent alterations to insecticide campaigns, and of the evolution of resistance genes in Chinese C. pipiens populations.

Environmental threats to children's health in Southeast Asia and the Western Pacific

The Southeast Asia and Western Pacific regions contain half of the world's children and are among the most rapidly industrializing regions of the globe. Environmental threats to children's health are widespread and are multiplying as nations in the area undergo industrial development and pass through the epidemiologic transition. These environmental hazards range from traditional threats such as bacterial contamination of drinking water and wood smoke in poorly ventilated dwellings to more recently introduced chemical threats such as asbestos construction materials; arsenic in groundwater; methyl isocyanate in Bhopal, India; untreated manufacturing wastes released to landfills; chlorinated hydrocarbon and organophosphorous pesticides; and atmospheric lead emissions from the combustion of leaded gasoline. To address these problems, pediatricians, environmental health scientists, and public health workers throughout Southeast Asia and the Western Pacific have begun to build local and national research and prevention programs in children's environmental health. Successes have been achieved as a result of these efforts: A cost-effective system for producing safe drinking water at the village level has been devised in India; many nations have launched aggressive antismoking campaigns; and Thailand, the Philippines, India, and Pakistan have all begun to reduce their use of lead in gasoline, with resultant declines in children's blood lead levels. The International Conference on Environmental Threats to the Health of Children, held in Bangkok, Thailand, in March 2002, brought together more than 300 representatives from 35 countries and organizations to increase awareness on environmental health hazards affecting children in these regions and throughout the world. The conference, a direct result of the Environmental Threats to the Health of Children meeting held in Manila in April 2000, provided participants with the latest scientific data on children's vulnerability to environmental hazards and models for future policy and public health discussions on ways to improve children's health. The Bangkok Statement, a pledge resulting from the conference proceedings, is an important first step in creating a global alliance committed to developing active and innovative national and international networks to promote and protect children's environmental health.

需求变更影响分析模型及相关技术研究

需求是后续开发活动的基准，早期的一些研究者认为应该在需求完全确定之后再进行后续开发，Royce所提出的瀑布模型就是这种思想的一个体现。但是，实践经验告诉我们，不管前期的需求分析做的多么完美，需求还是会发生变更。一方面是因为需求本身很复杂，对它的分析、理解和描述是一个循序渐进的过程，不可能一蹴而就；另一方面由于用户期望和偏好的改变、市场环境的转变、使用环境的日益复杂、技术的革新等都会使得原有的软件系统无法满足各涉众的利益。因此，需求变更是软件开发中固有的规律，是不可避免和普遍存在的。 需求变更通常会导致需求间及需求与后续工作产品间的不一致。因此，频繁的需求变更会造成产品质量下降、进度延期、成本超支等问题。变更影响分析(Change Impact Analysis)通过分析变更对象及其相关工作产品间的关系来评估变更造成的影响，从而控制变更。现有方法多数是从软件维护的角度，对代码的变更影响进行分析，过于细节和技术化，不能对需求变更影响分析提供有力支持。即使针对需求变更的影响分析方法也只是基于形式化需求规约，通过分析需求间的关系来识别影响范围，并未考虑需求变更对后续工作产品造成的影响，同时形式化需求规约的应用困难也限制了该方法的实用性。此外，随着需求和工作产品的规模与复杂性日益增加，使得手工建立和维护需求间及需求与工作产品间关系面临着不小的难度。 基于以上分析，本文提出了针对自然语言需求规约的需求变更影响分析模型RCIAM (Requirement Change Impact Analysis Model)，围绕着如何自动识别和筛选需求间的关系——横向需求跟踪关系(Horizontal Requirement Traceability)、如何自动识别和筛选需求与工作产品间的关系——纵向需求跟踪关系(Vertical Requirement Traceability)、如何较全面的进行需求变更影响计算和决策三个问题展开了研究。 本文的主要贡献有： (1) 提出了需求变更影响分析模型RCIAM 本文对RCIAM进行了形式化定义。该模型不但提供了需求变更影响分析算法和对决策的支持，还提供了自动识别横向和纵向需求跟踪关系的方法。RCIAM主要包含数据处理和数据分析两个层次。数据处理层采用了文本处理(Text Processing)技术实现了横向和纵向需求跟踪关系的自动识别，为数据分析层提供需求跟踪关系数据；数据分析层基于需求跟踪关系数据，在产生需求变更申请(Change Request)时，进行量化影响计算，并提供决策支持。 (2) 提出了横向需求跟踪关系的识别与筛选方法 在对自然语言需求规约文档进行深入分析后，我们发现了两种与需求变更影响密切相关的关系类型，并从文本相似性的角度将它们定义为相似跟踪关系和引用跟踪关系。在将需求项拆分为需求片段的基础上，利用信息检索技术(Information Retrieval，IR)计算需求片段间的文本相似度，并设计了相应的算法对相似跟踪关系和引用跟踪关系进行自动识别。最后，提出了“变更影响跟踪”的规则来辅助对候选跟踪关系的人工筛选。 (3) 提出了纵向需求跟踪关系的识别与筛选方法 已有的研究多采用IR技术来自动建立需求与工作产品之间的跟踪关系，但是却存在着精度不理想的问题。我们从查全率(Recall)和查准率(Precision)的角度，分析了应用IR技术自动建立需求与代码跟踪关系的方法中产生的错误关系，发现了造成精度问题的根源所在。依据这一发现，基于现有方法，本文方法加入了相关反馈(Relvant Feedback)辅助识别和代码注释信息辅助识别等改进措施，并提供了人工筛选策略。 (4) 提出了需求变更影响分析计算与决策方法 本文通过矩阵运算说明了需求变更影响通过需求跟踪关系传播到其它需求和工作产品的过程，并设计了相应的需求变更影响分析算法。该算法考虑变更发生在不同阶段时对不同类型工作产品的影响，采用变更类型和关系强度两个因子加权计算影响值，并提出了根据影响值来进行变更决策的方法。 (5) 应用研究 结合中科方德公司Qone平台的开发，对以上工作进行了应用研究和性能分析。在Qone平台的需求管理工具版本1.0的开发中，首先采用本文方法对横向和纵向需求跟踪关系进行了自动识别，然后对开发期间发生的十次需求变更申请进行了影响分析和决策。在项目完成后，设计了实验对横向和纵向需求跟踪关系的识别进行了性能分析。结果表明，本文方法能够有效辅助进行需求变更影响分析。

On-line voltammetric monitoring of dissolved Cu and Ni in the Gulf of Cadiz, south-west Spain

Geochemical processes in estuarine and coastal waters often occur on temporally and spatially small scales, resulting in variability of metal speciation and dissolved concentrations. Thus, surveys, which are aimed to improve our understanding of metal behaviour in such systems, benefit from high-resolution, interactive sampling campaigns. The present paper discusses a high-resolution approach to coastal monitoring, with the application of an automated voltammetric metal analyser for on-line measurements of dissolved trace metals in the Gulf of Cadiz, south-west Spain. This coastal sea receives metal-rich inputs from a metalliferous mining area, mainly via the Huelva estuary. On-line measurements of dissolved Cu, Zn, Ni and Co were carried out on-board ship during an eight-day sampling campaign in the study area in June 1997. A pumping system operated continuously underway and provided sampled water from a depth of ca. 4 m. Total dissolved metal concentrations measured on-line in the Gulf of Cadiz ranged between <5 nM Cu (<3 nM Ni) ca. 50 km off-shore and 60–90 nM Cu (5–13 nM Ni) in the vicinity of the Huelva estuary. The survey revealed steep gradients and strong tidal variability in the dissolved metal plume extending from the Huelva estuary into the Gulf of Cadiz. Further on-line measurements were carried out with the automatic metal monitor from the bank of the Odiel estuary over a full tidal cycle, at dissolved metal concentrations in the μM range. The application confirmed the suitability of the automated metal monitor for coastal sampling, and demonstrated its adaptability to a wide range of environmental conditions in the dynamic waters of estuaries and coastal seas. The near-real time acquisition of dissolved metal concentrations at high resolution enabled an interactive sampling campaign and therefore the close investigation of tidal variability in the development of the Huelva estuary metal plume.

Trends in heavy metal levels in the dissolved and particulate phase in the Dutch rhine-meuse (MAAS) delta*

Levels of the heavy metals Cd, Cr, Cu, Pb and Zn, in both the dissolved and particulate phase, were determined in two sampling campaigns in August 1978 and August 1984 in the Dutch Rhine-Meuse (Maas) Delta. Besides the heavy metal concentrations, other important parameters were determined, such as the concentrations of seston, chlorophyll and nutrients. The concentrations of dissolved Cd and of Cd, Pb and Cu in particulate matter were much higher in 1978 than in 1984, especially for Cd. This may be due to the strict regulations implemented in Germany to reduce the pollution of natural waters by heavy metals. The correlation between the high Cd content and the chlorophyll content is explained by the binding of Cd to living and dead organisms. The distribution of the metals between the dissolved and the particulate phase, indicated by the distribution quotient Kd , increases from low values of Kd for Cu and Zn, to higher values for Cd and Cr, and the highest values for Pb. The differences are explained by various binding forms of each of these metals in natural waters

新模糊形态学联想记忆网络的初步研究

人工神经网络理论已经被成功地应用于各种不同的模式识别问题 .重点研究了联想记忆网络 ,提出了一种新的基于形态学和模糊运算的联想记忆网络 ,即模糊形态学联想记忆网络FMAM .它与经典联想记忆和模糊联想记忆FAM有显著不同 .文中分析了FMAM的记忆能力和抗腐蚀 /膨胀噪声的能力 .自联想FMAM具有无限存储能力 ,能保证完全回忆 ,并且回忆在一步内完成 ,可模糊性解释等 .仿真实验验证了自联想FMAM的良好性能

改善三维波动方程叠前深度偏移处理效果的方法研究

3D wave equation prestack depth migration is the effective tool for obtaining the exact imaging result of complex geology structures. It's a part of the 3D seismic data processing. 3D seismic data processing belongs to high dimension signal processing, and there are some difficult problems to do with. They are: How to process high dimension operators? How to improve the focusing? and how to construct the deconvolution operator? The realization of 3D wave equation prestack depth migration, not only realized the leap from poststack to prestack, but also provided the important means to solve the difficult problems in high dimension signal processing. In this thesis, I do a series research especially for the solve of the difficult problems around the 3D wave equation prestack depth migration and using it as a mean. So this thesis service for the realization of 3D wave equation prestack depth migration for one side and improve the migration effect for another side. This thesis expatiates in five departs. Summarizes the main contents as the follows: In the first part, I have completed the projection from 3D data point area to low dimension are using de big matrix transfer and trace rearrangement, and realized the liner processing of high dimension signal. Firstly, I present the mathematics expression of 3D seismic data and the mean according to physics, present the basic ideal of big matrix transfer and describe the realization of five transfer models for example. Secondly, I present the basic ideal and rules for the rearrange and parallel calculate of 3D traces, and give a example. In the conventional DMO focusing method, I recall the history of DM0 process firstly, give the fundamental of DMO process and derive the equation of DMO process and it's impulse response. I also prove the equivalence between DMO and prestack time migration, from the kinematic character of DMO. And derive the relationship between DMO base on wave equation and prestack time migration. Finally, I give the example of DMO process flow and synthetic data of theoretical models. In the wave equation prestak depth migration, I firstly recall the history of migration from time to depth, from poststack to prestack and from 2D to 3D. And conclude the main migration methods, point out their merit and shortcoming. Finally, I obtain the common image point sets using the decomposed migration program code.In the residual moveout, I firstly describe the Viterbi algorithm based on Markov process and compound decision theory and how to solve the shortest path problem using Viterbi algorithm. And based on this ideal, I realized the residual moveout of post 3D wave equation prestack depth migration. Finally, I give the example of residual moveout of real 3D seismic data. In the migration Green function, I firstly give the concept of migration Green function and the 2D Green function migration equation for the approximate of far field. Secondly, I prove the equivalence of wave equation depth extrapolation algorithms. And then I derive the equation of Green function migration. Finally, I present the response and migration result of Green function for point resource, analyze the effect of migration aperture to prestack migration result. This research is benefit for people to realize clearly the effect of migration aperture to migration result, and study on the Green function deconvolution to improve the focusing effect of migration.

加工深度、记忆材料类型对FOK和FOnK判断的影响

Predecessors’ research found that feeling-of-knowing and feeling-of-not-knowing was two different cognitional processes. Processing depth had more good effects on FOK judgment, but it had little effects on FOnK judgment, furthermore, it perhaps decreased the accuracy of FOnK judgment. On the base of predecessors’ research the experiment discussed the different effects on FOK judgment and FOnK judgment by processing depth and memory materials of different kinds. The first purpose was to find that the effects of processing depth on FOK judgment and FOnK judgment were different or not. The second purpose was to reveal the two different memory materials of the Paired-Chinese-words and the Paired- Chinese-phonetic-alphabet would cause difference on the grade and accuracy of FOK judgment or not, and if the two different kinds of memory materials took different effects on FOK judgment and FOnK judgment. The third purpose was to search if there was interaction on processing depth and different kinds of memory materials. The experiment used the Paired-Chinese-words and the Paired- Chinese-phonetic-alphabet as the materials, and regarded processing depth in the time of encoding stage and different kinds of memory materials as the independent variable. The experiment regarded validity of memory; the grade of FOK judgment; the accuracy of FOK judgment; the accuracy of FOnK judgment as the dependent variable. The experiment adopted the “RJR” normal researching form of FOK judgment projected by Hart. The result of the researching proved that in the condition of deep processing in the time of encoding stage, the validity of memory; the grade of FOK judgment; the accuracy of FOK judgment were higher than in the condition of superficial processing, but processing depth had little effect on accuracy of FOnK judgment. FOK judgment and FOnK judgment were two different cognitional processes. Memory materials of different kinds led clear difference on the dependent variable of the validity of memory; the grade of FOK judgment; the accuracy of FOK judgment, and also had little effect on accuracy of FOnK judgment. Processing depth and different kinds of memory materials had interaction on their effects on FOK judgment. Regard the accuracy of recall, the percentage of “feeling of knowing”, the percentage of “feeling of not knowing”, and the grade of FOK judgment as the dependent variables, memory materials of different kinds make little effect in the condition of superficial processing in the time of encoding stage, but in the condition of deep processing in the time of encoding stage, Chinese characters was higher than Chinese phonetic alphabet.

学习不良儿童的元认知偏差及矫正

Metacognitive illusions or metacognitive bias is a concept that is a homologous with metacognitve monitor accuracy. In the dissertation, metacognitive illusions mainly refers to the absolute differences between judgment of learning (JOL) and recall because individuals are misguided by some invalid cues or information. JOL is one kind of metacognitive judgments, which is the prediction about the future performance of learned materials. Its mechanism and accuracy are the key issues in the study of JOL. Cue-utilization framework proposed by Koriat (1997) summarized the previous findings and provided a significant advance in understanding how people make JOL. However, the model is not able to explain individual differences in the accuracy of JOL. From the perspective of people’s cognitive bound, our study use posterior associative word pairs easy to produce metacognitive bias to explore the deeper psychological mechanism of metacontive bias. Moreover, we plan to investigate the cause to result in higher metacognitive illusions of children with LD. Based on these, the study tries to look for the method of mending metacognitive illusions. At the same time, we will summarize the findings of this study and previous literatures, and propose a revesied theory for explaining children’s with LD cue selection and utilization according to Koriat’s cue-utilization model. The results of the present study indicated that: (1) Children showed stable metacognitive illusions for the weak associative and posterior associative word pairs, it was not true for strong associative word pairs. It was higher metacognitive illusions for children with LD than normal children. And it was significant grade differences for metacognitive illusions. A priori associative strength exerted a weaker effect on JOL than it did on recall. (2) Children with LD mainly utilized retrieval fluency to make JOL across immediate and delay conditions. However, for normal children, it showed some distinction between encoding fluency and retrieval fluency as potential cues for JOL across immediate and delay conditions. Obviously, children with LD lacked certain flexibility for cue selection and utilization. (3)When word pairs were new list, it showed higher metacognitve transfer effects for analytic inferential group than heuristic inferential group for normal children in the second block. And metacognitive relative accuracy got increased for both children with and without LD across the experimental conditions. However, it was significantly improved only for normal children in analytic inferential group.

心理旋转中的整体优先效应及其机制

In the history of psychology research, more attention had been focused on the relation between local processing and global processing. For the global information and the local information, which is processed earlier? And which is processed faster? Precedence of the global over the local level in visual perception has been well established by Navon with compound stimuli, and Navon’s original study gave rise to many publications, including replications, generalization to other kinds of stimuli (nonverbal material, digits), populations (infants, children, brain-damaged subjects), and tasks (lateral visual hemifield presentation, copy drawing, memory recognition, and recall), and triggered some debate about the conditions in which global precedence is and is not observed (number, size, sparsity, and goodness of the stimuli, exposure duration, etc.). However, whether there is a global advantage or precedence in other cognitive processes was less tested. Most researches had suggested that there was a functional equivalency between visual perception and visual image processing. However, it’s still unknown whether there will be a global advantage on mental rotation. In the present study, we combined the mental rotation task with the compound stimuli to explore whether the global or local advantage also existed at the mental imagery transformation stages. In two pilot studies, the perceptual global precedence was found to be present in a normal/mirror-image judgment task when the stimuli exposure time was short; while the stimuli exposure time was prolonged (stimuli kept available till subjects’ response) the perceptual global precedence was showed to be eliminated. In all of the subsequent experiments, stimili would be presented till subjects’ response. Then mental rotation was added in normal/mirror-image judgment (some of the stimuli were rotated to certain angles from upright) in normal experiments, experiment 1 and 2 observed a global advantage on mental rotation both with a focused-attention design (Experiment 1) and divided-attention design (Experiment 2). Subjects’ reaction times were increased with rotation angles, and the accuracy was decreased with rotation angles, suggesting that subject need a mental rotation to make a normal/mirror judgment. The most important results were that subjects’ response to global rotation was faster than that to local rotation. The analysis of slope of rotation further indicated that, to some extend, the speed of global rotation was faster than that of local rotation. These results suggest a global advantage on mental rotation. Experiment 3 took advantage of the high temporal resolution of event-related potentials to explore the temporal pattern of global advantage on mental rotation. Event-related potential results indicated the parietal P300 amplitude was inversely related to the character orientation, and the local rotation task delayed the onset of the mental-rotation-related negativity at parietal electrodes. None clear effect was found for occipital N150. All these results suggested that the global rotation was not only processed faster than local rotation, but also occurred earlier than local rotation. Experiments 4 and 5 took the effect size of global advantage as the main dependent variable, and visual angle and exposure duration of the stimuli as independent variables, to examine the relationship between perceptual global precedence and global advantage on mental rotation. Results indicated that visual angle and exposure duration did not influence the effect size of global advantage on mental rotation. The global advantage on mental rotation and the perceptual global advantage seemed to be independent but their effects could be accumulated at some condition. These findings not only contribute to revealing a new processing property of mental rotation, but also deepen our understanding of the problem of global/local processing and shed light on the debate on locus of global precedence.

记忆年老化与焦虑

It is well established that memory functioning deteriorates with advancing age. However, research indicates that the magnitude of age-related memory deficits varies across different types of memory, and broad individual differences can be observed in the rate and timing of memory aging. The general aim of this study was to investigate the selectivity and variability of memory functioning in relation to anxiety. Firstly, memory effectiveness was assessed in episodic memory tasks with reality monitoring and external source monitoring paradigms, semantic memory tasks referred to general knowledge and word fluency, and perceptual priming task reflected in word completion. According to the scores on trait version of STAI, the high-trait and low-trait anxious subjects were screened respectively from young and old participants matched for educational level. Secondly, based on the results of the first part, concurrent primary and secondary tasks with probe technique assessing spare processing capacity were used to explore the relation between memory efficiency and anxiety. The first main findings were that: (a) there were no age-related differences in semantic memory assessed by general knowledge and PRS, whereas age effects were observed in episodic memory and semantic memory assessed by word fluency with stringent time restraints. (b) Furthermore, comparison of age-related deficits in source and item was not related to the presentation ways and encoding effort for source, but was affected by types of source. Specifically, memory was more sensitive to aging than item memory in external source monitoring processes involved in discriminating two external sources (i.e., female vs. male voices), but not in reality monitoring processes in discriminating between internal and external sources (i.e., acting vs. listening). The second main findings were that: (a) Anxiety had no effects on the effectiveness and efficiency of semantic memory in recall of general knowledge and PRS, but impaired those of semantic memory in word fluency. (b) The effects of anxiety on episodic memory were different between the old and the young. Both the effectiveness and the efficiency of episodic memory of the old were affected adversely by anxiety. More importantly, source recall in external source monitoring processes was observed to be more vulnerable to anxiety than item memory. The effectiveness of episodic memory of the young was relatively unrelated to anxiety, while anxiety might have adverse effect on their memory efficiency. These results indicated that: First, the selectivity of age-related memory deficits existed not only between memory systems, but also within episodic memory system. The tendency to forget the source even when the fact was retained in external source monitoring was suggested to be a specific feature of cognitive aging. Second, anxiety had adverse impact on the individual differences in memory aging, and mediated partial age-related differences in episodic memory performance.