Biosensors for fermentation process control

Two biosensors for fermentation process control have been introduced, which were developed in our lab recently. One is an enzyme electrode-based on-line monitoring system for glutamate fermentation process control and the other is an H+-ISFET-based ENFET for penicillin G fermentation process control.

Biosensors for fermentation process control

Two biosensors for fermentation process control have been introduced, which were developed in our lab recently. One is an enzyme electrode-based on-line monitoring system for glutamate fermentation process control and the other is an H+-ISFET-based ENFET for penicillin G fermentation process control.

软件质量管理中的统计过程控制

统计过程控制（SPC, Statistical Process Control）是一种借助数理统计工具的过程控制方法，它利用统计工具及技术（如控制图）对过程或过程输出进行分析，找出过程中的不确定因素并及时消除，控制、管理、改进过程产品的质量或过程能力，从而达到保证产品质量的目的。它能帮助用户采取适当措施来保证过程处于统计意义的受控状态，并且帮助用户提高生产能力，以满足或超越顾客的期望。SPC最早是在工业界提出的，在工业界的成功也促使它被应用于其它许多商业领域。本文主要探讨统计过程控制在软件质量管理中的实施。

基于统计过程控制的机器人系统故障预测技术研究

针对机器人系统维护特点,提出将故障预测与健康管理(PHM)技术应用到机器人系统的维护上。论述了PHM关键技术——故障预测技术的特点和研究内容,对故障预测技术进行分类和分析。最后提出了基于统计过程控制(SPC)进行故障预测的方法,描述了其控制图的原理和判断准则,并利用实际过程能力指数进行预测,阐述了进一步研究可能遇到的问题。

Spatial distribution of soil heavy metal pollution estimated by different interpolation methods: Accuracy and uncertainty analysis

Mapping the spatial distribution of contaminants in soils is the basis of pollution evaluation and risk control. Interpolation methods are extensively applied in the mapping processes to estimate the heavy metal concentrations at unsampled sites. The performances of interpolation methods (inverse distance weighting, local polynomial, ordinary kriging and radial basis functions) were assessed and compared using the root mean square error for cross validation. The results indicated that all interpolation methods provided a high prediction accuracy of the mean concentration of soil heavy metals. However, the classic method based on percentages of polluted samples, gave a pollution area 23.54-41.92% larger than that estimated by interpolation methods. The difference in contaminated area estimation among the four methods reached 6.14%. According to the interpolation results, the spatial uncertainty of polluted areas was mainly located in three types of region: (a) the local maxima concentration region surrounded by low concentration (clean) sites, (b) the local minima concentration region surrounded with highly polluted samples; and (c) the boundaries of the contaminated areas. (C) 2010 Elsevier Ltd. All rights reserved.

Enrichment and hydrogen production by marine anaerobic hydrogen-producing microflora

Acid, alkali, heat-shock, KNO3 and control pretreatment methods applied to anaerobic sludge were evaluated for their ability to selectively enrich the marine hydrogen-producing mixed microflora. Seawater culture medium was used as the substrate. The hydrogen yield of pretreated microflora was higher than that of the un-pretreated control (P < 0.05). Among the pretreatment methods studied, heat-shock pretreatment yielded the greatest hydrogen production, which was 14.6 times that of the control. When the effect of initial pH on hydrogen production of heat-shock pretreated samples was studied, hydrogen was produced over the entire pH range (pH 4-10). The hydrogen yield peaked at initial pH 8 (79 mL/g sucrose) and then steadily decreased as the initial pH increased. Sucrose consumption was high at neutral initial pH. During the process of hydrogen production, pH decreased gradually, which indicated that the acquired microflora consisted of acidogenic bacteria.

大气季节内振荡对东亚夏季风活动的影响研究

利用ERA40逐日再分析资料、NCEP/NCAR2逐日再分析资料、中国740个测站日降水资料、上海台风研究所提供的西太平洋热带气旋资料、Kaplan等重建的月平均SSTA资料、NOAA逐日长波辐射（OLR）等资料，应用离散功率谱分析、带通滤波、EOF分析等统计方法，研究了东亚夏季风(EASM）的移动特征、东亚地区季节内振荡(ISO)的基本特征、季节内振荡对东亚夏季风活动的影响、季节内振荡对东亚夏季风异常活动的影响机理。主要结论如下： （1）综合动力和热力因素定义了可动态描述东亚夏季风移动和强度的指数，并利用该指数研究了东亚夏季风的爆发和移动的季节内变化及其年际和年代际变化特征。研究发现，气候平均东亚夏季风前沿分别在28候、33候、36候、38候、40候、44候出现了明显的跳跃。东亚夏季风活动具有显著的年际变率，主要由于季风前沿在某些区域异常停滞和突然跨越北跳或南撤引起，造成中国东部旱涝灾害频繁发生。东亚夏季风的活动具有明显的年代际变化，在1965年、1980年、1994年发生了突变，造成中国东部降水由“南旱北涝”向“南涝北旱”的转变。 （2）东亚季风区季节内变化具有10~25d和30~60d两个波段的季节内振荡周期，以30-60d为主。存在三个主要低频模态，第一模态主要表征了EASM在长江中下游和华北地区活动期间的低频形势；第二模态印度洋-菲律宾由低频气旋式环流控制，主要表现了ISO在EASM爆发期间的低频形势；第三模态主要出现在EASM在华南和淮河活动期间的低频形势。第一模态和第三模态是代表东亚夏季风活动异常的主要低频形势。 （3）热带和副热带地区ISO总是沿垂直切变风的垂直方向传播。因此，在南海-菲律宾东北风垂直切变和副热带西太平洋北风垂直切变下，大气热源激发菲律宾附近交替出现的低频气旋和低频反气旋不断向西北传播，副热带西太平洋ISO以向西传播为主。中高纬度地区，乌拉尔山附近ISO以向东、向南移动或局地振荡为主；北太平洋中部ISO在某些情况下向南、向西传播。 （4）季风爆发期，伴随着热带东印度洋到菲律宾一系列低频气旋和低频反气旋， 冷空气向南输送，10~25天和30~60天季节内振荡低频气旋同时传入南海加快了南海夏季风的爆发。在气候态下，ISO活动表现的欧亚- 太平洋（EAP）以及太平洋-北美（PNA）低频波列分布特征(本文提出的EAP和PNA低频波列与传统意义上的二维定点相关得到的波列不同)。这种低频分布形式使得欧亚和太平洋中高纬度的槽、脊及太平洋副热带高压稳定、加强，东亚地区的低频波列则成为热带和中高纬度ISO相互作用影响东亚夏季风活动的纽带。不同的阶段表现不同的低频模态，30~60d低频模态的转变加快了EASM推进过程中跳跃性；30-60d低频模态的维持使得EASM前沿相对停滞。 （5）30-60d滤波场，菲律宾海域交替出现的低频气旋和低频反气旋不断向西北传播到南海-西太平洋一带。当南海-西太平洋地区低频气旋活跃时，季风槽加强、东伸，季风槽内热带气旋（TC）频数增加；当南海-西太平洋低频反气旋活跃时，季风槽减弱、西退，TC处于间歇期，生成位置不集中。 （6）在El Nino态下，大气季节内振荡偏弱，北传特征不明显，但ISO由中高纬度北太平洋中部向南和副热带西太平洋向西的传播特征显著，东亚地区ISO活动以第三模态为主，EASM集中停滞在华南和淮河流域，常伴随着持续性区域暴雨的出现，易造成华南和江淮流域洪涝灾害，长江和华北持续干旱。在La Nina态下，大气季节内振荡活跃，且具有明显的向北传播特征，PNA低频波列显著，东亚地区ISO活动以第一模态单峰为主；EASM主要停滞在长江中下游和华北地区，这些地区出现异常持续强降水，华南和淮河流域多干旱；在El Nino态向La Nina态转换期，ISO活动以第一模态双峰为主，长江中下游常常出现二度梅。

基于SPC的电源故障预测系统研究

本文结合飞行器电源系统故障维护特点,利用统计过程控制理论,从数理统计的角度对电源系统测试数据进行分析,设计了电源故障预测系统。文中阐述了系统的工作原理和利用LabView软件的实现过程。实验结果表明此预测系统可以发现故障征兆及时维护,提高系统安全性。最后阐述了进一步研究可能会遇到的问题。

机器人系统的故障预测技术研究

文章针对机器人系统维护特点,提出将故障预测与健康管理(PHM)技术应用到机器人系统的维护上。论述了PHM关键技术——故障预测技术的特点和研究内容。对故障预测技术进行分类和分析,总结出各种预测方法的特点。最后提出了基于统计过程控制(SPC)进行故障预测的方法,并阐述了进一步研究可能遇到的问题。

基于Labview开发统计过程控制软件

统计过程控制是质量管理的重要内容,介绍了SPC的原理,并用Labview软件实现了SPC软件。这种开发方法应用了Labview软件提供的统计过程控制模块,方便了程序的开发,很容易被质量人员掌握,设备改动或软件应用于别的设备时,只需简单地修改参数,大大方便了统计过程控制的普及,提高企业的质量水平。

生产线监控与管理系统的设计

介绍在Labview的开发环境下,装配检测生产线监控与管理系统的开发方法。该系统实现了检测数据的人机界面显示,查询打印,统计过程控制(SPC)以及每月的不合格工件计数。统计过程控制(SPC)实现了对生产线的实时监控及质量管理,其他三个软件模块实现了对生产线的自动化生产管理。这种模块化的生产线管理系统对设计同类软件具有借鉴意义。

黄骅坳陷大港探区油气资源潜力与资源结构预测

Facing the problems that Dagang region of Huanghua Depression has high exploration degree and its remaining resource potential and structure are not clear, the theory of Petroleum Accumulation System (PAS) is applied to divide and evaluate the oil/gas systems quantitatively. Then, the petroleum accumulation systems are taken as units to forecast and analyse the oil/gas resources and their structure using statistical methods of sampling analysis of discovery process model and generalized pareto distribution model. The exploration benefit of the unit is estimated using exploration simulation methods. On the basis of the above study, the resource potential of Huanghua Depression is discussed.Huanghua Depression can be diveded into four petroleum accumulation systems, i.e. North PAS5 Middle Qibei PAS, Middle Qinan PAS and South PAS. Each PAS can be diveded futher into several sub- PASs. Using the basic princple of Analytical Hierarchy Process, the method of quantitative evaluation of PAS is established. Then the elements and maturity of PAS are evaluated quantitatively.Taking migration and accumulation units and sub-PASs as prediction units, sampling analysis of discovery process model and generalized pareto distribution model are applied comparatively to forecast the resource structure of eight migration and accumulation units in six PASs of medium-high exploration degree. The results of these two methods are contrasted and analyzed. An examination of X2 data of these two models from exploration samples shows that generalized pareto distribution model is more effective than sampling analysis of discovery process model in Huanghua Depression. It is concluded that minimum and maximum size of reservoir and discovery sequence of reservoirs are the sensitive parameters of these two methods.Aiming at the difficult problem of forecast in low exploration degree, by analysis of relativity between resource parameters and their possible influential geological factors, forecast models for resource parameters were established by liner regressing. Then the resource structure is forecasted in PASs of low exploration degree.Based on the forecast results, beginning with the analysis of exploration history and benefit variation, the exploration benefit variation of the above PASs is fitted effectively using exploration simulation method. The single well exploration benefit of remaining oil resource is also forecasted reasonably.The results of resource forecast show that the total oil resources ofHuanghua Depression amount to 2.28 b illion ton. By the end o f 2 003, the accumulative total proved oil reserve is 0.90 billion ton and the remaining oil resources is 1.38 billion ton. The remaining oil resource is concentrated in Kongdian-Dengmingshi, Banqiao-Beidagang, Qidong-Yangerzhuang and Baidong-Qizhong sub-PASs.

交易型领导的结构和作用机制研究

The Multifactor Leadership theory developed by Bass (1985) has become the new paradigm of leadership research. The empirical results of the effectiveness of transformational and transactional leadership in the literature, however, are not consentient. Researchers in China found the different structure of transformational leadership, but have not developed the transactional leadership. This study attempts to investigate three key questions in the unique Chinese socio-economic context: 1) what is the structure of transactional leadership in China? 2) What are the differences between western countries and China? And 3) what is the relationship between the transformational and transactional leadership mechanism? This study examines data collected from 3,500 participants, using Explored Factor Analysis (EFA), Confirmed Factor Analysis (CFA), Hierarchical Regression Analyses, partial correlations and other statistics methods. The major finings are listed as follows： Firstly, inductive methods was used to explore the structure of transactional leadership and the result show that transactional leadership is a four dimensions structure which includes contingent reward, contingent punishment , process control and anticipated investment. Reliability analysis, item analysis, EFA and CFA show the reliability and validity of the transactional leadership questionnaire we designed is good enough, the design of the item is effectively and properly. Contrast to other researches, anticipated investment emphasis on the leader’s recessive investment for subordinate, and this kind of transaction is quite special under the Chinese culture. While the content of the contingent reward with the contingent punishment is wider than the contingent reward in the western country, and the process control is wider than the management by exception and including goal setting and the management during the process. Secondly, hierarchical regression analyses showed that transformational and transactional leadership were significant positively related with in-role performance, extra-role performance, satisfaction and leadership effectiveness while negatively related to intention to leave. The effects of transactional and transformational leadership are different. Transactional leadership could significantly predict intention to leave controlling for transformational leadership, while transformational leadership could significantly predict in-role performance, extra-role performance, satisfaction and leadership effectiveness controlling for transactional leadership. Thirdly, the income level and the rank of subordinates are the moderators between the transformational, transactional leadership and leadership effectiveness. The leadership effectiveness of transactional leadership would decrease as the rank of subordinates increased, while the leadership effectiveness of transformational leadership would increase as the rank of subordinates increased. Transactional leadership is positively related to the effectiveness when the level of the subordinate income is low, but negatively related to the effectiveness when the level of the subordinate income is high. However the income level of the subordinate could not influence the leadership effectiveness of transformational leadership.

心算年老化的认知心理机制及功能磁共振成像研究

Mechanisms underlying cognitive psychology and cerebral physiological of mental arithmetic with increasing are were studied by using behavioral methods and functional magnetic resonance imaging (fMRI). I. Studies on mechanism underlying cognitive psychology of mental arithmetic with increasing age These studies were accomplished in 172 normal subjects ranging from 20 to 79 years of age with above 12 years of education (Mean = 1.51, SD = 1.5). Five mental arithmetic tasks, "1000-1", "1000-3", "1000-7", "1000-13", "1000-17", were designed with a serial calculation in which subjects sequentially subtracted the same prime number (1, 3, 7, 13, 17) from another number 1000. The variables studied were mental arithmetic, age, working memory, and sensory-motor speed, and four studies were conducted: (1) Aging process of mental arithmetic with different difficulties, (2) mechanism of aging of mental arithmetic processing. (3) effects of working memory and sensory-motor speed on aging process of mental arithmetic, (4) model of cognitive aging of mental arithmetic, with statistical methods such as MANOVA, hierarchical multiple regression, stepwise regression analysis, structural equation modelling (SEM). The results were indicated as following: Study 1: There was an obvious interaction between age and mental arithmetic, in which reaction time (RT) increased with advancing age and more difficult mental arithmetic, and mental arithmetic efficiency (the ratio of accuracy to RT) deceased with advancing age and more difficult mental arithmetic; Mental arithmetic efficiency with different difficulties decreased in power function: Study 2: There were two mediators (latent variables) in aging process of mental arithmetic, and age had an effect on mental arithmetic with different difficulties through the two mediators; Study 3: There were obvious interactions between age and working memory, working memory and mental arithmetic; Working memory and sensory-motor speed had effects on aging process of mental arithmetic, in which the effect of working memory on aging process of mental arithmetic was about 30-50%, and the effect of sensory-motor speed on aging process of mental arithmetic was above 35%. Study 4: Age, working memory, and sensory-motor speed had effects on two latent variables (factor 1 and factor 2), then had effects on mental arithmetic with different difficulties through factor 1 which was relative to memory component, and factor 2 which relative to speed component and had an effect on factor 1 significantly. II. Functional magnetic resonance imaging study on metal arithmetic with increasing age This study was accomplished in 14 normal right-handed subjects ranging from 20 to 29 (7 subjects) and 60 to 69 (7 subjects) years of age by using functional magnetic resonance imaging apparatus, a superconductive Signa Horizon 1.5T MRI system. Two mental arithmetic tasks, "1000-3" and "1000-17", were designed with a serial calculation in which subjects sequentially subtracted the same prime number (3 or 17) from another number 1000 silently, and controlling task, "1000-0", in which subjects continually rehearsed number 1000 silently, was regarded as baseline, based on current "baseline-task" OFF-ON subtraction pattern. Original data collected by fMRI apparatus, were analyzed off-line in SUN SPARC working station by using current STIMULATE software. The analytical steps were composed of within-subject analysis, in which brain activated images about mental arithmetic with two difficulties were obtained by using t-test, and between-subject analysis, in which features of brain activation about mental arithmetic with two difficulties, the relationship between left and right hemisphere during mental arithmetic, and age differences of brain activation in young and elderly adults were examined by using non-parameter Wilcoxon test. The results were as following:

一种支持软件过程控制和改进的主动度量模型

提出了一种支持软件过程控制与改进的主动度量模型 AMM(active measurement model)和度量方法.模型形式化描述了软件过程的目标、特征和度量指标等关键元素以及相互间的关系,给出了确定软件过程度量的原则、方法和步骤.基于该度量模型,软件组织一方面可以依据确定的过程目标,主动导出合适的度量过程;另一方面还可以依据度量的结果,识别过程改进的机会,并主动导出过程改进的方向.为正确的决策和成功的结果提供有效的支持.