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The aim of this research is to explore the characteristics of family functioning���personality and their relation to anxiety and depression in high school students. A total of 914 high school students were assessed with The Chinese Family Assessment Instrument and Five -factor Personality Questionnaire and Mental Health Test and Middle School Students Depression Questionnaire. The result indicates, 1. The family functioning and Personality were all significant difference to school, gender, mother���s education and father���s education. 2. There were school, gender, mother���s education and father���s education differences in anxiety of students. 3. There were school, mother���s education and father���s education differences in depression of students. 4. Family functioning were predictive factor directly to anxiety of students, personality serves in part as medium between family functioning and anxiety of students. 5. Family functioning were predictive factor directly to the high school students��� depression, personality serves in part as medium between family functioning and depression of students. 6. The different schools had special features in relation models between family functioning, personality and anxiety of students. 7. The different schools had special features in relation models between family functioning, personality and depression of students.