Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: Possible mechanisms for corticosterone on opiate addiction

The hippocampus, being sensitive to stress and glucocorticoids, plays significant roles in certain types of learning and memory. Therefore, the hippocampus is probably involved in the increasing drug use, drug seeking, and relapse caused by stress. We have studied the effect of stress with morphine on synaptic plasticity in the CA1 region of the hippocampus in vivo and on a delayed-escape paradigm of the Morris water maze. Our results reveal that acute stress enables long-term depression (LTD) induction by low-frequency stimulation (LFS) but acute morphine causes synaptic potentiation. Remarkably, exposure to an acute stressor reverses the effect of morphine from synaptic potentiation ( similar to 20%) to synaptic depression ( similar to 40%), precluding further LTD induction by LFS. The synaptic depression caused by stress with morphine is blocked either by the glucocorticoid receptor antagonist RU38486 or by the NMDA-receptor antagonist D-APV. Chronic morphine attenuates the ability of acute morphine to cause synaptic potentiation, and stress to enable LTD induction, but not the ability of stress in tandem with morphine to cause synaptic depression. Furthermore, corticosterone with morphine during the initial phase of drug use promotes later delayed-escape behavior, as indicated by the morphine-reinforced longer latencies to escape, leading to persistent morphine-seeking after withdrawal. These results suggest that hippocampal synaptic plasticity may play a significant role in the effects of stress or glucocorticoids on opiate addiction.

面向大规模定制的软件开发模式

在领域工程、基于构件的软件工程和并行工程的基础上，提出了面向大规模定制的软件开发模式。该模式以大规模开发标准软件的效益满足用户的个性化需求。介绍了面向大规模定制的软件开发过程，面向大规模定制的软件产品族体系结构，以及面向大模型定制软件开发的产品集成过程模型。最后介绍了一种面向大规模定制的敏捷软件开发组织。

交易型领导的结构和作用机制研究

The Multifactor Leadership theory developed by Bass (1985) has become the new paradigm of leadership research. The empirical results of the effectiveness of transformational and transactional leadership in the literature, however, are not consentient. Researchers in China found the different structure of transformational leadership, but have not developed the transactional leadership. This study attempts to investigate three key questions in the unique Chinese socio-economic context: 1) what is the structure of transactional leadership in China? 2) What are the differences between western countries and China? And 3) what is the relationship between the transformational and transactional leadership mechanism? This study examines data collected from 3,500 participants, using Explored Factor Analysis (EFA), Confirmed Factor Analysis (CFA), Hierarchical Regression Analyses, partial correlations and other statistics methods. The major finings are listed as follows： Firstly, inductive methods was used to explore the structure of transactional leadership and the result show that transactional leadership is a four dimensions structure which includes contingent reward, contingent punishment , process control and anticipated investment. Reliability analysis, item analysis, EFA and CFA show the reliability and validity of the transactional leadership questionnaire we designed is good enough, the design of the item is effectively and properly. Contrast to other researches, anticipated investment emphasis on the leader’s recessive investment for subordinate, and this kind of transaction is quite special under the Chinese culture. While the content of the contingent reward with the contingent punishment is wider than the contingent reward in the western country, and the process control is wider than the management by exception and including goal setting and the management during the process. Secondly, hierarchical regression analyses showed that transformational and transactional leadership were significant positively related with in-role performance, extra-role performance, satisfaction and leadership effectiveness while negatively related to intention to leave. The effects of transactional and transformational leadership are different. Transactional leadership could significantly predict intention to leave controlling for transformational leadership, while transformational leadership could significantly predict in-role performance, extra-role performance, satisfaction and leadership effectiveness controlling for transactional leadership. Thirdly, the income level and the rank of subordinates are the moderators between the transformational, transactional leadership and leadership effectiveness. The leadership effectiveness of transactional leadership would decrease as the rank of subordinates increased, while the leadership effectiveness of transformational leadership would increase as the rank of subordinates increased. Transactional leadership is positively related to the effectiveness when the level of the subordinate income is low, but negatively related to the effectiveness when the level of the subordinate income is high. However the income level of the subordinate could not influence the leadership effectiveness of transformational leadership.

真实和虚拟现实环境下场景识别中的空间更新

Currently，one of the important research areas in Spatial updating is the role of external (for instance visual) and internal (for instance proprioceptive or vestibular) information in spatial updating of scene recognition. Our study uses the paradigm of classic spatial updating research and the experimental design of investigation of Burgess(2004),first, we will explore the concrete influence of locomotion on scene recognition in real world; next, we will use virtual reality technology, which can control many spatial learning parameters and exclude the influence of extra irrelevant variables, to explore the influence of pure locomotion without visual cue on scene recognition, and furthermore, we will explore whether the ability of spatial updating can be transferred to new situations in a short period of time and compare the result pattern in real word with that in virtual reality to test the validity of virtual reality technology in spatial updating of scene recognition research. The main results of this paper can be summarized as follows： 1. In real world, we found two effects: the spatial updating effect and the viewpoint dependent effect, this result indicated that the spatial updating effect based on locomotion does not eliminate the viewpoint dependent effect during the scene recognition process in physical environment. 2. In virtual reality environment, we still found two effects: the spatial updating effect and the viewpoint dependent effect, this result showed us that the spatial updating effect based on locomotion does not eliminate the viewpoint dependent effect during the scene recognition process in virtual reality environment either. 3. The spatial updating effect based on locomotion plays double role in scene recognition: When subjects were tested in different viewpoint, spatial updating based on locomotion promoted scene recognition; while subjected were tested in same viewpoint, spatial updating based on locomotion had a negative influence on scene recognition, these results show us that spatial updating based on locomotion is automated and can not be ignored. 4. The ability of spatial updating can be transferred to new situations in a short period of time , and the experiment in the immersed virtual reality environment got the same result pattern with that in the physical environment, suggesting VR technology is a very effective method to do research on spatial updating of the scene recognition studies. 5. This study about scene recognition provides evidence to double system model of spatial updating in the immersed virtual reality environment.

迁移性安慰剂效应的多模态机制 ：从痛觉到情绪的行为、ERP和fMRI研究

Although studies on placebo effect proved the placebo expectation established by pain-alleviating treatment could significantly alleviate later pain perception, or the placebo expectation established by anxiety-reducing treatment could significantly reduce the intensity of induced negative feelings, it is still unclear whether or not the placebo effect can occur in a transferable manner. That is, we still don’t know if the placebo expectation derived from pain-alleviating can significantly reduce later negative emotional arousal or not. Experiment 1: We compared the effect of the verbal expectation (purely verbal induction and without pain-alleviating reinforcement) with the reinforced expectation (building the belief in the placebo’s ataractic efficiency on unpleasant picture processing by secret reduction of the intensity of the pain-evoking stimulus) on the negative emotion. The results showed that the expectation, which was reinforced by actual analgesia, was transferable and could produce significant placebo effect on negative emotional arousal. However, the expectation that was merely induced by verbal instruction did not have such power. Experiment 2 both examined the direct analgesic effect of the placebo on the sensory pain (how strong is the pain stimulus) and emotional pain (how disturbing is the pain stimulus) and the transferable ataractic effect of the placebo on the negative emotion (how disturbing is the emotional picture stimulus), and further proved that the placebo expectation that was established from pain-reducing reinforcement not only induced significant placebo effect on pain, but also significant placebo effect on unpleasant feeling. These results support the viewpoint that the reduction of affective pain based on the conditioning mechanism plays an important role in the placebo analgesia, but can’t explain the transferred placebo effect on visual unpleasantness. Experiment 3 continued to use the paradigm of the reinforced expectation group and recorded the EEG activities, the data showed that the transferable placebo treatment was accompanied with decreased P2 amplitude and increased N2 distributed, and significant differences between the transferable placebo condition and the control condition (i.e., P2 and N2) were observed within the first 150-300 ms, a duration brief enough to rule out the possibility that differences between the two conditions merely reflect a bias “to try to please the investigator. In Experiment 4, we selected the placebo responders in the pre-experiment and let them to go through the formal fMRI scan. The results found that the transferable placebo treatment reduced the negative emotional response, emotion-responsive regions such as the amygdala, insula, anterior cingulate cortex and the thalamus showed an attenuated activation. And in the placebo condition, there was an enhanced activation in the subcollosal gyrus, which may be involved in emotional regulation. In conclusion, the transferable placebo treatment induced the reliable placebo effect on the behavior, EEG activity and bold signal, and we attempted to discuss the pychophysiological mechanism based on the positive expectancy.

线索语义相容性的研究

With the studies of the Stimulus-Response Compatibility (SRC), more and more psychologists consider that the compatibility isn't only exist between stimulus and stimulus, response and response, but also any two sets in the information processing, it means that the compatibility is the basic feature of the human information processing. Research on the compatibility of the precue is a powerful evidence to support the issue. Dimension Overlap Model (Kornblum, 1990) is one of the most popular models to explain the mechanism of the SRC which focus on the dimension overlapping between the stimulus and response will activate the compatible response automatically, the compatibility effects origin from whether the compatible response prove or interference the response, the so the time course between the automatic activation and the task processing cause the dynamical time feature of the SRC (Kornblum, 1997). Yet the DO model has gotten many supports, it hasn't been tested in the paradigm of the precue task. At the same time, company with the development of the Environment Psychology, the effect of the ex-information in the environment on the inside information processing has drown much attention, does the validity probability of the cue have any influence on the cue compatibility? How about the relationship of the cue compatibility and the SRC? Research on the questions will reveal the characteristics of the human information processing, enhance the knowledge of the compatibility phenomena and resource, enlarge the field of SRC and produce more practice usage on the design of human-machine system. The mechanism and influence factors of symbolic compatibility between cue and stimulus were investigated within a precueing paradigm. The influence of the dimension overlapping relation between the cue and the stimulus, cue and the response on the reaction time were studied under the different kinds of SRC, to test whether or not it confirms the dimension overlap hypothesis, to test is there any effect of SOA and validity probability of cues on the cue compatibility. The results showed that the cue compatibility exists and owns such features: 1, It confirms the dimension overlap model that the cue which dimension overlapped with the stimulus or the response will influence the efficiency of the processing, the reaction time is shorter when the cue is congruent with the stimulus or the response that that of the incongruent cue; 2, Consistent to the automatic activation hypothesis, the time course is the important characteristic of the cue compatibility. The largest compatibility effect can be gotten from the middle duration of SOA. 3, The validity probability of cues influence the cue compatibility significantly, the strength of the cue compatibility effect grows stronger with the higher validity probability of cues. 4, The cue compatibility affect the effect of SRC, especially when the cue is compatible with the stimulus; 5, The cue compatibility has two-fold meaning, the cue-stimulus compatibility and the cue-response compatibility, the former is stronger than the later when they compete each other. In summary, the compatibility, the basic feature of human information processing, is proved by the research, and the dimension overlap model and automatic activation hypothesis is tested by the studying on the cue compatibility.

小学儿童空间物体位置编码的实验研究

As a key issue in spatial cognitive developmental research, the coding of object location plays an important role in children's cognitive development. The development of location coding is a precondition for children's adaptation to their environments, and the development of corresponding ability could enhance children's adaptation ability and improve their synthetic diathesis. In this paper, under the improved paradigm of object searching, 7-, 9- and 11-year-olds of urban primary school students were involved in two studies including the total of four experiments. The children were examined upon the ability to encode target location in terms of the distance between two landmarks, three points on a line, the intersection of two lines, or the corresponding points on two parallel lines. The experiments were designed to explore the primary school children's cognitive developmental process upon spatial object location and the correlative restricting factors. From the studies, the following conclusions were drawn: 1)The ability of 7-year-olds to represent target location in terms of the relationships of points and lines is in the inceptive stage and appears unstable. Meanwhile, the same ability of 9-year-olds is in a state of fast developing. The 9-year-olds' performance depends on how difficult the task is. It is stable when task is easy while unstable when task becomes difficult. The ability of 11-year-olds reaches much-developed state and the group's performance is independent of the difficulty of tasks. 2) The correlate coefficient is significant between Raven Standard Inference ability levels and the performance of representing target location in terms of the relationships of points. Those children with good performance in Raven Standard Inference Test have good performance in target location coding. The case is true for all different age groups. As of the task in terms of the relationships of lines, the correlate coefficient between Raven Standard Inference ability levels and children's performance of representing target location is found significant only for the 7-year-olds' group. The case is not true for the groups of 9- and 11-year-olds. It is also found that the correlate coefficient is significant between the sum of performance and Raven Standard Inference ability levels, and that is true for all age groups. 3) Effects from task variable exist upon children's above-mentioned cognitive performance. The effects are different according to different difficulty levels of tasks. Also, they are different according to the different ages. 4) The subjects who failed in the 'no cues for encoding given' situation were able to improve their performances when the cues of encoding were given. Therefore it is possible to improve the primary school children's corresponding cognitive performance by providing the cues of encoding. 5) Two kinds of efficient strategies were used to solve the problem. They are trial-comparison strategy and anticipation-directed strategy.

汉字音匹配和半球加工

This study explores hemispheric processing and relations during the homophone matching. In the literature summary, we review the past studies employing Tachistoscopic Presentation of Divided View Field (DVF) to the two hemispheres cooperation, and point out the different and complex opinions about both homophone matching and hemispheric processing. to some focuses, we handle this study by six behavioral experiments. First, under the condition of stimulus presenting simultaneously and function of graphic/semantic dimension, we study the bilateral/unilateral processing efficiency, the function on the level of synonym/similar grapheme. Main result shows, during homophone matching, bilateral processing is better than unilateral one, i.e., bilateral processing advantage rises. For further study whether the effects of transferring information between hemispheres will change along the time, combining with the paradigm of Priming, we make the stimulus present in the certain order; and under the function of graphic/semantic dimension, we also study the bilateral/unilateral processing efficiency, the function on the level of synonym/similar grapheme. Results show, there is semantic/graphic information which brings effects on homophone matching transferring between two hemispheres. And semantic/graphic information can be affected with the time, for example, when SOA = 210ms, the effect of semantic/graphic information disappears. When homophone present in the sequence, bilateral processing advantage also disappears, there are no significant differences between bilateral processing and unilateral one. In addition, we also explore whether sex differences exist during bilateral homophone matching, and we get, there are no significant differences between different sex. Among all experimental results, we also find several special phenomenon as the following example: 1) when stimuli presenting simultaneously during homophone matching on the level of synonym/similar grapheme, the processing effect of LVF(Left View Field) is better than RVF (Right View Field). 2) when stimuli presenting simultaneously, during homophone matching on the level of synonym/similar grapheme, one hemisphere may inhibit the other (because of the interference). to wrap up, under certain condition bilateral processing advantage is obtained, and during the interhemispheric interaction when homophone matching, some kind of information will relay between two hemispheres. And when two hemispheres cooperate, mutual inhibition (or interference) also follows. Further, interhemispheric interaction is closely connected with time, the attribution of stimuli, and so on. At last, a model is put forward to describe the coordinated process and the possible relations between two hemispheres.