汉语发展性阅读障碍的神经心理学研究The Neuropsychological Basic of Chinese Developmental Dyslexia by ERP Study

本论文实验结果发现汉语阅读障碍在视听觉功能上有非语言特异性的感知觉加工缺陷：他们在完成视觉任务时成绩稍差，反应时延长，ERP波形成分的峰潜伏期也延长，波幅降低，尤其是左侧枕叶视皮层对右侧视野投射信号的加工效能差，这是首次报道他们枕叶视皮质的左右差异；他们完成听觉分辨任务时，对听觉分辨的效能比正常儿童低；尤其是在听觉相关电位中的表现，峰潜伏期延长，波幅降低。他们在视听觉双通道信号整合的加工上仍表现出ERP波形成分的峰潜伏期延长，波幅较低的现象；综合这三方面的结果，可以推论阅读障碍者可能对一般的信息进行感知觉加工的效能弱。 他们在同音字判断任务中表现出有语音意识缺陷：完成同音字判断任务的正确率与正常儿童有显著的差异；对假字的加工和形似同音字的加工产生的ERP波形均与正常儿童有显著差异，这种差异尤其在左脑更明显。 结合Franck的理论，推论汉语阅读障碍形成原因：汉语阅读障碍行为表现多种多样，这些变异性可能有一些共同的神经心理基础；由于出生前神经的异常发育，遗传的异常或环境的影响而导致的大脑左右两半球功能的差异，尤其左半球引起其对语言加工的缺陷，可能伴随出现视听觉等基本的感知觉功能障碍。

语音意识缺陷儿童的言语知觉技能

Considerable studies find that developmental dyslexia is associated with deficits in phonological processing skills, especially phonological awareness. In order to explore the nature of phonological awareness deficits in dyslexia, researchers have begun to investigate the role of speech perception. The findings about speech perception abilities in dyslexics are inconsistent. The heterogeneity of dyslexia may be responsible for the inconsistency of findings. Considering the general suggestion that phonological awareness deficits in dyslexia are attributed to categorical perception deficits, it is more direct to examine whether children with phonological awareness difficulties or phonological dyslexia show speech categorization deficits consistently. The present study would investigate whether Chinese children with phonological awareness deficits or phonological dyslexia showed abnormal speech perception. The whole study consisted of two parts. Part I screened children with phonological-awareness deficits from Year 3 kindergartens and examined their abilities of perceiving native category continuum, nonnative category contrasts and non-speech sound series. Part II selected phonological dyslexics from an elementary school as participants, and further explored the relation between phonological deficits and speech perception. The first two experiments of Part II examined separately the abilities to label stimuli in native category continuum and brief stops in different contexts, the last experiment investigated the adaptation effects of different participant groups. The main conclusions are as follows: 1) Children with phonological dyslexia showed categorical perception deficits: they had lower consistency than controls when perceiving stimuli within phonetic categories, especially for the stimuli which were not natural sounds. 2) Children with phonological dyslexia exhibited a general difficulty of perceiving brief segments of stops from different contexts. 3) Children with phonological dyslexia did not show adaptation to repeatedly presented stimuli. Based on the present conclusions and the findings of previous studies, we suggested that the representations of sound stimuli in phonological dyslexics’ brains are different from those in normal children’s; the representations of sound stimuli in dyslexics’ cortical neural networks are more diffuse and inconsistent.

汉语深层失读及词汇－语义系统的认知神经心理学研究

Chinese deep dyslexia is an important type of reading disorder that attracted many research interests. In the current thesis, three studies concerning Chinese deep dyslexia were performed: (1) clinical dominating and incidental symptoms were collected and their relationships were analyzed, and error scores of different character and word types compared; to verify typical reading model of alphabetic readers, and to develope a novel model for reading Chinese scripts; (2) based on these results, further neuropsychological analysis on the basic rules of lexical-semantic system and semantic distance were employed; (3) rehabilitation scheme were shaped to verify our research results. With cognitive neuropsychological methods, this study was mainly focused on deep dyslexic patients with brain impairment. The results were compared with those of normal people on rapid reading. Computer emulation was also used to describe reading process of patients. Both group analysis and case study were carried out. This study for the first time systematically investigated the clinical symptoms of Chinese deep dyslexia. A novel model was developed with a hypothesis that the sublexical pathway is composed of two parallel pathways: the phonetic sublexical pathway and the semantic sublexical pathway. Two characteristics of Chinese deep dyslexia were found compared with alphabetic deep dyslexia: (1) having no distinct word class effect and imagination effect; (2) the organization of Chinese lexical-semantic system has correlation with construct regulation, imagination and splitability of characters. Evoking of semantic correlation is stronger than phonetic correlation.

知觉组织在拥挤现象中的作用

Crowding, generally defined as the deleterious influence of nearby contours on visual discrimination, is ubiquitous in spatial vision. Specifically, long-range effects of non-overlapping distracters can alter the appearance of an object, making it unrecognizable. Theories in many domains, including vision computation and high-level attention, have been proposed to account for crowding. However, neither compulsory averaging model nor insufficient spatial esolution of attention provides an adequate explanation for crowding. The present study examined the effects of perceptual organization on crowding. We hypothesize that target-distractor segmentation in crowding is analogous to figure-ground segregation in Gestalt. When distractors can be grouped as a whole or when they are similar to each other but different from the target, the target can be distinguished from distractors. However, grouping target and distractors together by Gestalt principles may interfere with target-distractor separation. Six experiments were carried out to assess our theory. In experiments 1, 2, and 3, we manipulated the similarity between target and distractor as well as the configuration of distractors to investigate the effects of stimuli-driven grouping on target-distractor segmentation. In experiments 4, 5, and 6, we focused on the interaction between bottom-up and top-down processes of grouping, and their influences on target-distractor segmentation. Our results demonstrated that: (a) when distractors were similar to each other but different from target, crowding was eased; (b) when distractors formed a subjective contour or were placed regularly, crowding was also reduced; (c) both bottom-up and top-down processes could influence target-distractor grouping, mediating the effects of crowding. These results support our hypothesis that the figure-ground segregation and target-distractor segmentation in crowding may share similar processes. The present study not only provides a novel explanation for crowding, but also examines the processing bottleneck in object recognition. These findings have significant implications on computer vision and interface design as well as on clinical practice in amblyopia and dyslexia.

汉语发展性阅读障碍儿童的视觉大细胞通路特点

Developmental dyslexia (DD) is a common kind of learning disorder, which affects 5-18% of people. It seems important to explore the deficit in visual magnocellular pathway in Chinese developmental dyslexia, for many researches demonstrated that one of the core deficits of Chinese developmental dyslexia was orthographic deficit which was associated with the deficit in visual magnocellular pathway. Two studies were done to detect the differences among Chinese developmental dyslexics, average readers of the same chronological age (CA controls) and average readers of the same reading level (RL controls) in reaction time, accuracy and visual mismatch negativity (vMMN) elicited by the moving gratings responded by visual magnocellular pathway. There were two grating-conditions which were low contrast/low spatial frequency condition and high contrast/high spatial frequency condition respectively. In ERP study, a modified “cross-modal delayed response” paradigm was used to elicit the vMMN. The results showed that the developmental dyslexics responded slower than CA controls, had more errors than RL controls, and had smaller amplitudes of vMMNs than the two controls in visual magnocellular pathway condition, but not in control condition. That is to say, Chinese developmental dyslexics had deficits in visual magnocellular pathway.