分离扇回旋加速器的接受度及效率；Acceptance and efficiency of sector-separated cyclotron

以9.7MeV/u的238U36+,5.62MeV/u的70Zn10+为典型离子,分析并模拟了分离扇回旋加速器(SSC)的注入、加速和引出,得到了SSC在理论等时场下横向和纵向的接受度。为了研究SSC在实际情况下的接受度,在实测场的基础上采用Kr-Kb方法以及Lagrange插值方法建立了与实际比较符合的等时场,计算了该等时场下SSC横向和纵向的接受度,发现了导致SSC实际接受度和传输效率低的主要原因在于注入系统中的MSI3元件和引出系统中的MSE3元件设计存在缺陷。模拟结果显示,通过改变MSI3和MSE3的曲率或者垫铁改变元件内部的场分布可以改善SSC的实际接受度和传输效率。

Construction and test of Wien-filter combined with RIBLL

A recoil separator Wien-filter which was developed for the Radioactive Ion Beam Line in Lanzhou (RIBLL) as an extension is described. It consists of 2 quadruple triplets and a standard Wien-filter. It was designed for study of the fusion-evaporation reactions. The overall design, background suppression, the transmission efficiency, the angular acceptance and the momentum acceptance have been described. All the performances fulfil the designed requirements. Based on the test results, with some modifications the investigations of the nuclei with Z <= 110 and the drip-line nuclei in the medium-heavy mass region can be carried out with this facility.

Pre-irradiation with low-dose C-12(6+) beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOI of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in C-12(6+) beam induced AdCMV-p53 infected cells were more than 90%, which were significantly more than those in gamma-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose 12C6+ beam significantly prevented the G(0)/G(1) arrest and activated G(2)/M checkpoints. The pre-exposure to C-12(6+) beam significantly improved cell to apoptosis. RBEs for the C-12(6+)+ AdCMV-p53 infection groups were 30%-60%,20% -130% and 30%-70% more than those for the C-12(6+)_irradiated only, AdCMV-p53 infected only, and gamma-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose C-12(6+) beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.

The integration of coastal zone management into national development planning

The broad acceptance and collective commitment of countries to the tasks involved in the implementation of Agenda 21, Chapter 17, have profound implications vis-à-vis the interplay between coastal zone management (CZM) and national development planning (NDP). It appears that in many countries, CZM has evolved in isolation from the mainstream of national development processes. The paper examines various forms and elements for the effective integration of CZM into NDP.