Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209)

Polybrominated diphenyl ethers (PBDEs) are an important class of halogenated organic brominated flame retardants. Because of their presence in abiotic and biotic environments widely and their structural similarity to polychlorinated biphenyls (PCBs), concern has been raised on their possible adverse health effects to humans. This study was designed to determine the anti-proliferative, apoptotic properties of decabrominated diphenyl ether (PBDE-209), using a human hepatoma Hep G2 line as a model system. Hep G2 cells were cultured in the presence of PBDE-209 at various concentrations (1.0-100.0 mu mol/L) for 72 h and the percentage of cell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The results showed that PBDE-209 inhibited the cells viability in time and concentration-dependent characteristics at concentrations (10.0-100.0 mu mol/L). We found that anti-proliferative effect of PBDE-209 was associated with apoptosis on Hep G2 cells by determinations of morphological changes, cell cycle and apoptosis. Mechanism study showed that PBDE-209 could increase the generation of intracellular reactive oxygen species (ROS) concentration-dependently. Antioxidant N-acetylcyteine partially inhibited the increase of ROS. The mechanism for its hepatoma-inhibitory effects was the induction of cellular apoptosis through ROS generation. In addition, activity of lactate dehydrogenase (LDH) release increased when the cells incubated with PBDE-209 at various concentrations and times. These results suggested that PBDE-209 had the toxicity activity of anti-proliferation and induction of apoptosis in tumor cells in vitro. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

~(209)Fr的能级结构研究

利用能量为 90— 1 0 5MeV的16 O束流 ,通过197Au( 16 O ,4n)反应研究了2 0 9　Fr的高自旋态能级结构 .进行了γ射线的激发函数、γ γ延迟符合及γ射线的角分布测量 .首次建立了由 2 1条γ射线构成的2 0 9Fr的能级纲图 ,其中包括一个半寿命为 ( 52± 2 0 )ns的同质异能态 .基于2 0 9Fr与2 0 8Rn低位能级结构的相似性 ,用一个h9/ 2 价质子与2 0 8Rn激发态的弱耦合解释了2 0 9Fr的低位能级结构 .

~(12)C与~(209)Bi反应中Au同位素的产额与Q_(gg)的关系；Q_(gg)-Yield Dependence of Au Isotopes in Interaction of 47 MeV/u ~(12)C With ~(209)Bi

用47MeV/u12C离子轰击天然铋靶,通过炮弹和靶核之间的核子转移反应产生Au同位素。使用放射化学方法从大量Bi和复杂反应产物中分离、纯化Au,并制备Au的γ射线测量源。使用HPGe探测器测量放射性Au同位素的γ活性。根据照射结束时Au同位素的活度和其他相关数据,确定每个Au同位素的产生截面。分析发现,缺中子Au同位素的产生截面与Qgg值之间不遵从指数依赖关系,这可用重离子碰撞中的次级过程加以解释。

47MeV/u~(12) C轰击~(197)Au和~(209)Bi引起的裂变关联测量

本论文的工作：利用两体裂变角关联技术，辅之以飞行时间测量，测定了47MeV/u的~(12)C轰击~(197)Au和~(209)Bi靶中心碰撞对应的线性动量转移（LMT），得到了关联裂片出射的共面歧离分布，同时还发现了关联角很小且共面歧离很大的裂变事件，并得到了其相对速度分布。从测到的LMT分布中，得到中心碰撞对应的最可几线性动量转移约占入射动量的65％，相应于单核子线性动量转移约为192MeV/c.A，进而还估算出了所形成热核的激发能上限。在对关联裂片出射的共面歧离效应研究中，发现了共面歧离宽度是热核激发能的较好量度之一。并给出了共面歧离宽度跟热核单核子激发能的经验关系；还用简化的裂片级联蒸发模型估算了蒸发中子、质子和α粒子的平均多重性

25MeV/u~(40)Ar~(15+)+~(209)Bi反应的裂变研究

本文首先回顾了重离子物理学的发展简史，并介绍了当前的一些关于重离子反应的理论方法，同时对于现在核物理的研究热点，热核的特性进行了概括性的叙述．由于裂变是作者工作的重点，因此在文章中，对裂变反应的理论也进行了介绍．为了能够清楚全面的说明我们的工作，本文对于实验装置和探测器也给出了详细的描述．最后，文章对25 MeVu Ar+Bi反应中的裂变进行了讨论．在这些讨论中，我们分析了反应中与裂变相关的数据，得到了碎片的质量，动能分布。同时运用与碎片相关联的4He粒子能谱提取了核温度和裂前裂后的4He粒子多重性，并利用这一数据计算了不同初始激发能下的裂点激发能和裂变时标.

变形介质双渗模型非线性流动模拟

在碳酸盐油藏和低渗油藏的渗流问题研究中,传统的研究方法都是假设地层渗透率是常数,然而对于地层渗透率是压力敏感的,这样的假设,对压力的变化将导致较大的误差.研究了应力敏感地层中双渗流动模型的压力不稳定响应,不仅考虑了储层的双渗特征,而且考虑了应力敏感地层中介质的变形,建立了应力敏感地层双孔隙度、双渗透率流动的数学模型,渗透率依赖于孔隙压力变化的流动方程是强非线性的,采用Douglas-Jones预估-校正法获得了圆井定产量生产和定压生产时无限大地层情况下的数值解,并探讨了变形参数和双重介质参数变化时压力变化规律,给出了典型压力曲线图版和应用实例.

An anisotropic elastic-plastic constitutive model for single and polycrystalline metals. II—Experiments and predictions concerning thin-walled tubular OFHC copper

Predictions based on an anisotropic elastic-plastic constitutive model proposed in the first part of this paper are compared with the experimental stress and strain data on OHFC copper under first torsion to about 13% and partial unloading, and then tension-torsion to about 10% along eight different loading paths. This paper also describes the deformation and stress of the thin-walled tubular specimen under finite deformation, the numerical implementation of the model, and the detailed procedure for determining the material parameters in the model. Finally, the model is extended to a general representation of the multiple directors, and the elastic-viscoplastic extension of the constitutive model is considered.

复合材料结构力学

<正> 复合材料结构力学研究复合材料的杆、板、壳及其组合结构的应力分析、变形、稳定和振动等各种力学问题,在广义上属于复合材料力学的一个分支。由于其内容丰富,问题重要和研究对象不同,已成为和研究复合材料力学问题的狭义复合材料力学并列的学科分支。 Ⅰ.复合材料结构的力学特点

等离子体湍流对电子的加速

本文讨论了等离子体湍流对电子加速的两种模型:(1)假定在空间中存在一个空间均匀的等离子体湍流区,当具有一定初始分布的电子束通过此湍流区时,研究湍流场对电子束的加速过程;(2)在某一封闭的区域中,存在着具有一定初始分布和空间均匀的等离子体,当某种类型的等离子体波突然传入此等离子体区,然后考察此区中电子的加速过程。在这两种模型中,可能存在着某种电子消失机制。假定湍谱是幂指数形式,我们给出了不同类型湍流扩散系数的普遍形式。利用较简单的数学方法,求解了包括消失过程的一维准线性动力学方程,对于给定的初始分布,得出了分布函数的解析解,并给出了平均能量时间关系的表达式。另外,对于特定的湍谱指数,解出了当平行电场和湍流同时存在时的分布函数。最后,对所得结果进行了数值分析和讨论。

On the topological bifurcation of flows around a rotating circular cylinder

Flow fields around a rotating circular cylinder in a uniform stream are computed using a low dimensional Galerkin method. Results show that the formation of a Fopple vortex pair behind a stationary circular cylinder is caused by the structural instability in the vicinity of the saddle located at the rear of the cylinder. For rotating cylinder a bifurcation diagram with the consideration of two parameters, Reynolds number Re and rotation parameter a, is built by a kinematic analysis of the steady flow fields.