216 resultados para HLA-G antigens


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细齿缺萼苔 (G .crenulatumGott.exCarr.)的中国记录为错误鉴定 ,标本实为中华缺萼苔(G .sinenseK .Muell.) ,应被移出中国苔藓植物区系。研究发现了多号西藏产中华缺萼苔标本 ,将中华缺萼苔其在中国的分布范围从云南的模式产地扩展到了西藏。对中华缺萼苔进行了形态特征描述和分布分析 ,并提供了特征示意图

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“仿真是一种基于模型的活动”,任何仿真系统都不能离开模型的支持,如果每次开发新的系统都要重新建立模型,费时费力。随着仿真系统的日益复杂,导致仿真模型的结构也日趋复杂,模型管理亦日趋繁琐。因此,研究一种有效的模型管理方法,对于方便模型重用,提高开发效率有着重要的意义。实现对模型的有效管理,首先需要明确管理对象,然后把模型有条理的分类并且规范的描述出来,最后把模型存储在数据库中,供用户重用。论文首先在HLA联邦开发执行过程的基础上,分析和完善了HLA仿真建模体系,明确了HLA仿真中模型的层次;然后总结了现有的模型分类方法,从方便模型统一管理的角度,提出了一种可扩展的模型分类方法;引入了元数据和XML技术,实现了对模型的规范化描述;根据课题研究目的,提出了仿真模型管理系统的设计目标,并设计了系统的体系结构、功能模块和数据结构;最后,综合应用数据库、VC++等技术,实现了模型存储、模型的增、删、改、查以及用户管理等功能,实现了对于模型的统一管理。

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Thrombin-binding aptamer is found to bind hemin to form a catalytic complex whose activity is significantly promoted by the addition of thrombin, which enables the colorimetric detection of thrombin with high specificity and sensitivity in a facile way.

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Two new stepladder conjugated polymers, that is, poly(7,7,15,15-tetraoctyldinaphtho[1,2-a:1',2'-g]-s-indacene) (PONSI) and poly(7,7,15,15-tetra(4-octylphenyl)dinaphtho[1,2-a:1',2'-g]-s-indacene) (PANSI) with alkyl and aryl substituents, respectively, have been synthesized and characterized. In comparison with poly(indenofluorene)s, both polymers have extended conjugation at the direction perpendicular to the polymer backbone because of the introduction of naphthalene moieties. The emission color of the polymers in film state is strongly dependent on the substituents. While PONSI emits at a maximum of 463 nm, PANSI with the same backbone but aryl substituents displays dramatically redshifted emission with a maximum at 494 nm.

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This paper presented a new approach for preparing a new type of slow-release membrane-encapsulated urea fertilizer with starch-g-PLLA as biodegradable carrier materials. By solution-casting and washing rapidly with water the urea was individually encapsulated within the starch matrix modified by L-lactide through in situ graft-copolymerization.

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Here, we report the first example that one enantiomer of a supramolecular cylinder can selectively stabilize human telomeric G-quadruplex DNA. The P-enantiomer of this cylinder has a strong preference for G-quadruplex over duplex DNA and, in the presence of sodium, can convert G-quadruplexes from an antiparallel to a hybrid structure. The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage.

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A cation-driven allosteric G-quadruplex DNAzyme (PW17) was utilized to devise a conceptually new class of DNA logic gate based on cation-tuned ligand binding and release. K+ favors the binding of hemin to parallel-stranded PW17, thereby promoting the DNAzyme activity, whereas Pb2+ induces PW17 to undergo a parallel-to-antiparallel conformation transition and thus drives hemin to release from the G-quadruplex, deactivating the DNAzyme. Such a K+-Pb2+ switched G-quadruplex, in fact, functions as a two-input INHIBIT logic gate. With the introduction of another input EDTA, this G-quadruplex can be further utilized to construct a reversibly operated IMPLICATION gate.

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Two significant G-quadruplex aptamers named AGRO100 and T30695 are identified as multi functional aptamers that can bind the protein ligands nucleolin or HIV-1 integrase and hemin. Besides their strong binding to target proteins, both AGRO100 and T30695 exhibit high hemin-binding affinities comparable to that of the known aptamer (termed PS2M) selected by the in vitro evolution process. Most importantly, their corresponding hemin-DNA complexes reveal excellent peroxidase-like activities. higher than that of the reported hemin-PS2M DNAzyme. This enables these multifunctional aptamers to be applied to the sensitive detection of proteins. which is demonstrated by applying AGRO100 to the chemiluminescence detection of nucleolin expressed at the surface of HeLa cells. Based on the specific AGRO100-nucleolin interaction, the surface-expressed nucleolin of HeLa cells is labeled in situ with the hemin-AGRO100 DNAzyme, and then determined in the luminol-H2O2 system.