Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study

The effects of aniracetam on extracellular amino acid levels in the hippocampus of conscious gerbils, with or without transient cerebral ischemia/reperfusion, were measured by microdialysis and reverse phase-high performance liquid chromatography. Increased extracellular levels of aspartate and glutamate that were observed in the hippocampus of conscious gerbils during transient global forebrain ischemia were reversed by aniracetam. In contrast, the level of extracellular gamma-aminobutyric acid was increased, while taurine was maintained at a higher level than other amino acids by administration of aniracetam (100 mg/kg, p.o.) 60 min before ischemia. Further, in contrast to ischemic animals, administration of aniracetam (100 mg/kg, p.o.) enhanced the release of glutamate and aspartate in the normal gerbil hippocampus. The results suggest that these effects might be due to a partial calcium agonist activity of aniracetam, and that the effects of aniracetam on amino acid levels might be a mechanism of protection against delayed neuronal death in the ischemic hippocampus, thereby improving memory dysfunction induced by ischemia/reperfusion. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

6种常用渔药对厚颌鲂鱼苗的急性毒性试验

在水温29~30℃条件下,用硫酸铜与硫酸亚铁合剂(比例5:2)、高锰酸钾、晶体敌百虫、强氯精、溴氯菊脂、甲醛共6种药物对厚颌鲂(Megalobrama pellegrini)鱼苗进行急性毒性试验。试验结果显示,6种药物48h的半致死浓度分别为5.78、6.50、4.90、2.55、0.042、120mg/L,安全浓度分别为0.445、0.528、0.268、0.190、0.003、7.500mg/L,厚颌鲂鱼苗对药物敏感性比一般鱼类高,实际用药时应根据具体情况确定用药时间和用药量,溴氯菊脂不宜作为治疗药物

收割对穗花狐尾藻生长的影响

在水深为24cm的桶中,以6、12和18cm等3个收割强度对穗花狐尾藻(Myrio-phyllum spicatum)进行了连续4次收割实验,研究了收割强度、收割频次及收割季节对穗花狐尾藻生长恢复的影响。结果表明:8月下旬第1次收割18cm后,植物在41d恢复,但产生分枝较少,影响了植物的无性繁殖;9月下旬之前,前2次收割6cm或12cm后,穗花狐尾藻在55d恢复,并能产生较多的分枝,而且条枝总长有明显的增加,表明穗花狐尾藻的无性繁殖没有受到抑制;10月初第2次收割18cm,或11月下旬前第3次收割6或1

黄鳝摄食活饵的初步研究

本文对不同体重的黄鳝摄食蚯蚓、蝌蚪、蛴螬的饵料系数、特定生长率、能量转化效率和最大摄食量等作了初步研究。结果表明 :在限食试验中 ,黄鳝摄食蚯蚓、蝌蚪、蛴螬的饵料系数分别为 3.2 83.89、7.0 99.0 7、3.393.4 2 ;特定生长率分别为 0 .33% 1.0 9%、1.0 9% 1.2 0 %、0 .6 5 % 0 .70 % ;能量转化效率分别为2 4 .9% 2 9.5 %、33.2 % 34.1%、2 8.8% 2 9.1%。饵料系数、特定生长率的大小主要决定于饵料性质 ,与体重(

单克隆抗体技术在水生动物病毒研究中的应用

“淡水生态与生物技术”国家重点实验室开放课题(2002FB07); 国家自然科学基金(30170726); 中国科学院及中国科学院水生生物研究所创新项目(KSCX2-SW-302与220313)