Phomoeuphorbins A-D, azaphilones from the fungus Phomopsis euphorbiae

Four azaphilones, named phomoeuphorbins A-D (1-4) were isolated from cultures of Phomopsis euphorbiae, an endophytic fungus isolated from Trewia nudiflora. Structures of 1-4 were established on the basis of spectroscopic analyses, including application of

Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus

Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were eluci

Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval

D-Serine, the endogenous coagonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be an important gliotransmitter, and is essential for the induction of long-term potentiation. However, less is known about the role of D-serine in another for

三黄果蝇(Drosophila trilutea)近黄果蝇(D. paralutea)的有丝分裂中期染色体

用产于日本的D. paralutea和产于昆明的D. trilutea三龄幼虫的脑神经节作染色体制片,进行C-带染色观察。其正常染色体与亚组种D. takahashil的染色体十分相似,染色体数均为2n=8。发现在所有的分裂细胞中几乎都包含1对微小染色体。图4参1

NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo

Behavioral stress facilitates long-term depression but impairs long-term potentiation in the hippocampus. Recent evidence in vitro demonstrates that the NIR2B-containing N-methyl-D-aspartate subtype glutamate receptor antagonist Ro25-6981 prevents the beh

N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus

Long term potentiation in hippocampus, evoked by high-frequency stimulation, is mediated by two major glutamate receptor subtypes, alpha-amino-3-hydroxyl-5-methyl-4-isoxazole propionate receptors and N-methyl-D-aspartate receptors. Receptor subunit compos

Genetic diversity and origin of Chinese cattle revealed by mtDNA D-loop sequence variation

To determine the origin and genetic diversity of Chinese cattle, we analyzed the complete mtDNA D-loop sequences of 84 cattle from 14 breeds/populations from southwest and west China, together with the available cattle sequences in GenBank. Our results sh

猕猴群D���逆转录病毒感染的控制与猕猴资源的保护和利用

猕猴群Ｄ型逆转录病毒感染的控制与猕猴资源的保护和利用贲昆龙（中国科学院昆明动物研究所）猴获得性兔疫缺陷综合征（ＳＡＩＤＳ）简称猴艾滋病，是一种严重危害猴类的疾病，它的传播可影响灵长类资源的保护和在生物医学中的合理利用。已有文献报道，一旦猴艾滋病传入易...

DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS

Dopamine (DA) D-1 receptor compounds were examined in monkeys for effects on the working memory functions of the prefrontal cortex and on the fine motor abilities of the primary motor cortex. The D-1 antagonist, SCH23390, the partial D-1 agonist, SKF38393, and the full D-1 agonist, dihydrexidine, were characterized in young control monkeys, and in aged monkeys with naturally occurring catecholamine depletion. In addition, SKF38393 was tested in young monkeys experimentally depleted of catecholamines with chronic reserpine treatment. Injections of SCH23390 significantly impaired the memory performance of young control monkeys, but did not impair aged monkeys with presumed catecholamine depletion. Conversely, the partial agonist, SKF38393, improved the depleted monkeys (aged or reserpine-treated) but did not improve young control animals. The full agonist, dihydrexidine, did improve memory performance in young control monkeys, as well as in a subset of aged monkeys. Consistent with D, receptor mechanisms, agonist-induced improvements were blocked by SCH23390. Drug effects on memory performance occurred independently of effects on fine motor performance. These results underscore the importance of DA D-1 mechanisms in cognitive function, and provide functional evidence of DA system degeneration in aged monkeys. Finally, high doses of D-1 agonists impaired memory performance in aged monkeys, suggesting that excessive D-1 stimulation may be deleterious to cognitive function.

线粒体D-loop序列变异与东方鲀属鱼类系统发育

东方鲀属的红鳍东方鲀(Takifugu rubripes)是后基因组时代的一种重要模式生物。本研究中,利用东方鲀属11种鱼类(18尾)的D-loop基因序列,对东方鲀属鱼类的系统发育关系进行研究。经序列比对排定后,分析中D-loop序列有841个位点,其中395个位点为可变位点,267个位点为系统发育信息位点。分别采用邻接法(NJ)、最大简约法(MP)、最大似然法(ML)和贝叶斯方法构建了分子系统树。研究结果表明:(1)东方鲀属鱼类为一单系类群;(2)由横纹东方鲀(T. oblongus)和铅点东方鲀(T

线粒体DNA d-loop序列变异与鳅鮀亚科鱼类系统发育

对鳅鮀亚科(Gobiobotinae)2个属8个种10个个体线粒体控制区d-loop全序列进行了测定.以(鱼丹)亚科斑马鱼为外类群,对鳅鮀及鲤科(Cyprinidae)一些亚科代表种鱼类进行了系统发育分析.结果显示,鳅鮀鱼类是一个单系类群,与鮈和细鲫有较近的亲缘关系.从系统发育的角度看,鳅鮀亚科应归属于鮈亚科(Gobioninae).研究结果支持鳅鮀亚科分为异鳔鳅鳅属(Xenophyso-gobio)和鳅鮀属(Gobiobtia).