广西高原鳅属鱼类一穴居新种记述

2003 年1 月, 在广西壮族自治区天峨县红水河水系地下河采集到一批盲鱼标本。经鉴定, 为高原鳅 属Triplophysa 一未经发表的新种。新种天峨高原鳅Triplophysa tianeensis sp1nov1 与个旧盲高原鳅T. gejiuensis 、 石林盲高原鳅T. shilinensis 、阿庐高原鳅T. aluensis 和南丹高原鳅T. nandanensis 相似; 本新种腹鳍末端不达 肛门, 尾鳍分枝鳍条16 , 可进一步与个旧盲高原鳅和石林盲高原鳅(腹鳍末端达到肛门, 尾鳍分枝鳍条14～ 15) 相区别; 本新种背鳍起点位于体之中点、腹鳍起点之后, 肛门紧靠臀鳍起点, 可进一步与阿庐高原鳅(背 鳍起点靠近吻端、位于腹鳍起点之前, 肛门距臀鳍起点仍有一段距离) 相区别。本新种与同分布于红水河水系 的南丹高原鳅Triplophysa nandanensis Lan et al1 较为相似; 但二者区别明显: 新种背鳍分枝鳍条7 、胸鳍分枝鳍 条9 、腹鳍分枝鳍条6 、背鳍外缘平截、背鳍起点位于腹鳍起点之后, 后者背鳍分枝鳍条8 、胸鳍分枝鳍条10～ 11 、腹鳍分枝鳍条7 、背鳍外缘凹入、背鳍起点位于腹鳍起点之前; 此外, 新种的穴居特征更为显著: 眼极度 退化、头长为眼径1618～3218 (2510) 倍、部分个体无色素斑且各鳍无斑点, 而南丹高原鳅眼小、头长为眼径 417～910 (715) 倍、体和头背侧密布云状斑且各鳍均具点状斑。

A new species of Genus Triplophysa (Nemacheilinae: Balitoridae), Triplophysa longipectoralis sp nov, from Guangxi, China

A new species, Triplophysa longipectoralis, is described from Liujiang River, Guangxi, China. The new species is distinguished from other species of Triplophysa by the following combination of characters: pectoral fin highly developed, reaching beyond pel

昆明山海棠对中国仓鼠V_(79)细胞二酰基甘油含量的影响

研究以昆明山海棠根部水抽提物(Tripterygium hypoglaucum (Level) Hutch,THH)处理中国仓鼠V_(79)细胞,通过检测V_(79)细胞C-M细胞频率以及二酰基甘油(1,2-diacylgcerol,DAG)的含量测定,分析了THH诱发非整倍体与细胞醇磷酯信号通路的关系。结果指出:THH能在1mg/ml、2mg/ml两个剂量上使V_(79)细胞的DAG含量显著升高(P<0.001),并明显的提高C-M细胞频率(P<0.05),提示肌醇酯信号通路是介导THH诱发非整倍体的途径之一。

In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate

Sodium rutin sulfate (SRS) is a sulfated rutin modified from the natural flavonol glycoside rutin. Here, we investigated its in vitro anti-HIV and -HSV activities and its cytotoxic profile. Fifty percent inhibitory concentration (IC50) values of SRS against HIV-1 X4 virus IIIB, HIV-1 R5 isolates Ada-M and Ba-L were 2.3 +/- 0.2, 4.5 +/- 2.0 and 8.5 +/- 3.8 mu M with a selectivity index (SI) of 563, 575 and 329, respectively. Its IC50 against primary R5 HIV-1 isolate from Yunnan province in China was 13.1 +/- 5.5 mu M, with a Sl of 197. In contrast, unsulfated rutin had no activity against any of the HIV-1 isolates tested. Further study indicated that SRS blocked viral entry and virus-cell fusion likely through interacting with the HIV- I envelope glycoprotein. SRS also demonstrated some activity against human herpes simplex virus (HSV) with an IC50 of 88.3 +/- 0.1 mu M and a Sl of 30. The 50% cytotoxicity concentration (CC50) of SRS was >3.0 mM, as determined in human genital ME 180, HeLa and primary human foreskin fibroblast cells. Minimum inhibitory concentration of SRS for vaginal lactobacilli was >3.0 mM. These results collectively indicate that SRS represents a novel candidate for anti-HIV-1/HSV microbicide development. (C) 2007 Elsevier B.V. All rights reserved.