72 resultados para 12C6
Resumo:
(HIRFLCSR),(CSRm)(SFC)7MeV/u,0.5%12C6+,CSRm,1GeV/u,
Resumo:
HIRFL12C6+C57BL/6JLewisLewis.,.,,.,.4Gy3,8Gy312Gy23,P0.05;.
Resumo:
1 2 C6 + 1 2 C6 + (LET 36 70keV m) , ,CB 0 6Gy , ,Y =6 6 5 0 9D0 .851 2 C6 + 0 6Gy
Resumo:
Human hepatoma (SMMC-7721) and normal liver (L02) cells were irradiated with c-rays, 12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou (HIRFL). By using the Calyculin-A induced premature chromosome condensation technique, chromatid-type breaks and isochromatid-type breaks were scored separately. Tumor cells irradiated with heavy ions produced a majority of isochromatid break, while chromatid breaks were dominant when cells were exposed to c-rays. The relative biological effectiveness (RBE) for irradiation-induced chromatid breaks were 3.6 for L02 and 3.5 for SMMC-7721 cell lines at the LET peak of 96 keVlm 1 12C6+ ions, and 2.9 for both of the two cell lines of 512 keVlm 1 36Ar18+ ions. It suggested that the RBE of isochromatid-type breaks was pretty high when high-LET radiations were induced. Thus we concluded that the high production of isochromatid-type breaks, induced by the densely ionizing track structure, could be regarded as a signature of high-LET radiation exposure.
Resumo:
: 12C6+, (LET) LET. : 3, 2,1. 2, 6,. 80100mev/u 3 72120 GyE/6212 f, (RBE) =3. :2 3mo,;1 75%,,100%..:12C6+,,. ,.
Resumo:
The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOI of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in C-12(6+) beam induced AdCMV-p53 infected cells were more than 90%, which were significantly more than those in gamma-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose 12C6+ beam significantly prevented the G(0)/G(1) arrest and activated G(2)/M checkpoints. The pre-exposure to C-12(6+) beam significantly improved cell to apoptosis. RBEs for the C-12(6+)+ AdCMV-p53 infection groups were 30%-60%,20% -130% and 30%-70% more than those for the C-12(6+)_irradiated only, AdCMV-p53 infected only, and gamma-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose C-12(6+) beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.
Resumo:
The brain of the Kun-Ming strain mice were irradiated with 0.05 Gy of C-12(6+) ion or Co-60 gamma-ray as the pre-exposure dose, and were then irradiated with 2 Gy of 12C6+ ion or Co-60 gamma-ray as challenging irradiation dose at 4 h after per-exposure. Body weight and serum growth hormone (GH) concentration were measured at 35th day after irradiation. The results showed that irradiation of mouse brain with 2 Gy of C-12(6+) ion or Co-60 gamma-ray significantly diminished mouse body weight and level of serum GH. The relative biological effectiveness values of a 2 Gy dose of C-12(6+) ion calculated with respect to Co-60 gamma-ray were 1.47 and 1.34 for body weight and serum GH concentration, respectively. Pre-exposure with a low-dose (0.05 Gy) of C-12(6+) ion or Co-60 gamma-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by a subsequent high-dose (2 Gy) irradiation. The data suggested that low-dose ionizing irradiation can induce adaptive hormetic responses to the harmful effects of pituitary by subsequent high-dose exposure.
Resumo:
::296,13,Bowens6,2,2(5070)GyE/(612)d,5.511.67GyE,1f/d,RTOGWHO:2009-05,13.5(125),100%29(CR)24(82.8%),(PR)5(17.2%),(RR)100%,22.8(95%CI:20.624.9)011(37.9%),9(31.0%),6(20.7%),2(6.9%),1(3.4%);:(12C6+),,
Resumo:
(12C6+),12()100MeV/u,RBE(Relative biologic effectiveness)2.5-3.0,60-70GyE,2.5-5.41Gy,1f/d,6-7d3,(RTOG)3,10(CR),2(PR),1-2,,,,,
Resumo:
(melatonin,MLT)10mg/kgMLT,1h00.51.02.04.0Gy12C6+,1.4Gy/min,8h,SODMDAGSH,,10mg/kgMLTSODGSHMDA;,MLT,MIT,,DNA
Resumo:
BJ1,,,12C6+BJ1:BJ1200~400 Gy,(LET)60 keV/m;BJ12%~21%;BJ117.48%,
Resumo:
N-(NAC)(ALCAR)12C6+,4Gy12C6+NAC(100mg/kg)ALCAR(100mg/kg)(TAC)DNA,,NACALCAR(P<0.001),12C6+DNA(P<0.001)(P<0.001),ALCARNAC(P<0.05)NACALCAR,DNA,CALCARNACC
Resumo:
12C6+B1aZJAV-A1,,12C6+50Gy97%,34.2%12C6+,,,B1a44604588g/ml,11.1%14.7%ZJAV-Y1-203
