关于蜕变测试和特殊用例测试的实例研究

提出了基于蜕变测试方法的集成测试环境MTest,进而为检验蜕变测试方法的能力和效率,以稀疏矩阵乘法程序为例设计了一组实验.该实验基于变异分析技术,分别以mutation score和错误发现率为度量指标,定量地分析和对比了特殊用例测试,以特殊测试用例和随机测试用例为源测试用例的蜕变测试这3种方法的测试能力和效率.该实验可在MTest测试环境下自动完成.实验结果表明,蜕变测试与特殊用例测试之间是互补的,而且就蜕变测试的源测试用例而言,随机测试用例在测试能力和效率上优于特殊测试用例.

一种基于模型的并发系统测试目的描述

提出了带约束事件的时序逻辑TLCE,用于描述系统运行中输入/输出事件之间的时序关系以及对事件参数的数据相关性约束.阐述了一种基于模型的并发系统测试框架,采用TLCE描述测试目的以引导测试用例生成.缓存一致性协议和会议协议的实例研究中所生成的测试用例集显著优于随机测试用例集.这说明了TLCE作为测试目的描述的有效性.

传值系统的互模拟与谓词等式系

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

模型检测:理论、方法与应用

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

面向传值进程的一阶模态逻辑的可判定性与模型检测

对于面向传值进程的Hennesssy-Milner逻辑的一阶扩充HML(FO)，给出了基于带赋值的符号迁移图的语义解释。证明了HML(FO)的子逻辑HML(FO^2)是满足性可判定的，并且讨论了判定的复杂性。最后给出了传值进程关于HML(FO^2)的模型检测的可判定性结果。

带复杂数据结构的模型检测工具

模型检测是近二十几年来最成功的自动验证技术之一,而模型检测工具的开发是将模型检测和实际相结合的关键.为了有效地对涉及到复杂数据类型的并发传值系统进行模型检测,总结了以扩展的带赋值符号迁移图和模态图分别作为并发系统和逻辑公式的语义模型来实现模型检测工具的工作,特别是将复杂数据结构引入传值进程定义语言和带赋值符号迁移图.同时结合实际例子说明模型检测工具的有效性.

谓词μ演算和模态图的语义一致性

模态图是谓词μ演算的一种有效的图形表示形式。证明了谓词μ演算和模态图的语义一致性，详细讨论了谓词μ演算公式、嵌套谓词等式系和模态图之间的关系，并给出了一种优化的从线性公式到嵌套谓词等式系的转换算法。

面向传值进程的谓词μ-演算与FO(HML)的完备推演系统

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

π-演算互模拟判定算法的优化和实现

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

带赋值符号迁移图的局部优化算法

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

嵌套谓词等式系与弱互模拟

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

移动进程的空间逻辑

提出了一个用于描述异步π-演算中移动进程的时态和空间性质的模态逻辑.该逻辑具有基于谓词变量的递归构造.建立了这一逻辑的语义理论,并证明了语义的单调性,从而保证了不动点的存在.还设计了一个算法来自动地检测移动进程是否具有用该逻辑公式所描述的性质,并证明了该算法的正确性.

高可靠软件研究:向信息技术的未来投资

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

a higher-order duration calculus and its completeness

National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Office

毛蕊异黄酮类似物的合成及其对JAK/STAT信号途径调控的构效关系研究

干扰素（IFNs）是最早发现的具有广泛用途的一类细胞因子，IFN-α通过JAK/STAT信号途径调控机体一系列生理和病理反应。至今尚未发现类干扰素的小分子。我们前期研究发现天然产物毛蕊异黄酮可激活干扰素诱导的JAK/STAT信号途径。为发现类干扰素小分子、获得小分子探针，本课题拟建立成熟的JAK/STAT信号途径的筛选模型，合成毛蕊异黄酮及其类似物，研究这些化合物的构效关系，进而尝试通过共价键标记生物素或香豆素来直接研究它们与相关受体的作用。 从异香草醛出发经7步合成反应得到了毛蕊异黄酮。采用平行合成策略得到异黄酮类化合物；采用分支式合成策略，以取代苯乙酸作为合成砌块，获得具有与异黄酮类似结构的香豆素、3-芳基喹诺酮。与分离得到的黄酮类化合物，构建了一个包括异黄酮、黄酮、香豆素、3-芳基喹诺酮在内的化合物库。 建立了包含IFN-α刺激反应元件 (ISRE)的荧光素酶报告基因体系，通过筛选化合物库中的化合物，发现异黄酮骨架为激活JAK/STAT信号途径必须结构、毛蕊异黄酮7-位酚羟基被取代后活性丧失。根据以上结果，对毛蕊异黄酮3′-位标记物的合成进行了初步尝试。 发现山茱萸科植物青荚叶(Helwingia japonica (Thunb.) Dietr.)有抑制蛋白酪氨酸磷酸酯酶1B（PTP1B）的活性。从其地上部分95%乙醇提取物的乙酸乙酯部分分离得到5个化合物,应用波谱方法及与已知品对照的手段鉴定它们为p-menth-2-en-1β, 4β, 8-triol (Z-1)、blumenol A (Z-2)、2′,3′,4′,5′,6′-五羟基查尔酮(Z-3)、洋芹素7-O-β-D-吡喃葡萄糖苷(Z-4)、木犀草素7-O-β-D-吡喃葡萄糖苷(Z-5). Interferons (IFNs) are one kind of cytokines with broad functions. IFN-α mediates series physiological and pathological changes of human body via JAK/STAT pathway. Untill now, no IFNs-like small molecules are discovered. In our preliminary experiment, the natural product calycosin has been observed to activate JAK/STAT pathway. Therefore, we establish a luciferase reporter gene system and synthesize calycosin and its analogues to reveal their structure-activity relationship (SAR). Besides, in order to prove that calycosin activates JAK/STAT pathway through IFN receptor, we attempted to tag it with biotin or coumarin by covalent bonding. Calycosin was synthesized from isovanillin via seven steps. Other isoflavones were obtained by parallel synthesis; coumarins and quinolones were prepared through divergent synthesis, using substituted phenylacetic acids as building blocks. Combing with natural flavones, a small molecule library was established. A luciferase reporter gene system, consisting of 5 copies of the ISRE (interferon-stimulated response element), was used for screening of small molecules from that library. We found that the core-structure of isoflavone was necessary, and if the 7-OH is substituted, the activity slumps. According to our observation, we tried to tag biotin or coumarin at 3′-OH of calycosin. The 95% ethanol extract of the aerial parts of Helwingia japonica (Thunb.) Dietr. showed protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Five compounds were isolated. On the basis of spectral data or by comparison with authentic samples, they were identified as p-menth-2-en-1β,4β,8-triol (1), blumenol A (2), 2′,3′,4′,5′,6′-pentahydroxychalcone (3), apigenin 7-O-β-D-glucopyranoside (4), and luteolin 7-O-β-D-glucopyranoside (5).