The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats

The effects of morphine on hippocampal sensory gating (N40) during the development of morphine dependence and withdrawal were investigated in the double click auditory evoked potential (EP) suppression paradigm. Rats were made dependent upon morphine hydrochloride by a series of injections (every 12h) over 6 days, followed by withdrawal after stopping morphine administration. Hippocampal gating was examined during the development of dependence and withdrawal. Moreover, the DA antagonist haloperidol was used to assess the contribution of dopamine to hippocampal gating induced by morphine. Our results showed that the morphine-treated rats exhibited significantly disrupted hippocampal gating during the development of morphine dependence and this disrupted gating was partially reversed by haloperidol pretreatment. In contrast, there was significantly enhanced hippocampal gating at the fifth and sixth days of withdrawal. The dynamics of hippocampal gating during the development of morphine dependence and withdrawal suggests the interaction between the hippocampus and opioids. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Influence of physical parameters of sound on the sensory gating effects of N40 in rats

Sensory gating is the ability of the brain to modulate its sensitivity to incoming stimuli. The N40 component of the auditory evoked potential, evaluated with the paired click paradigm, was used to probe the gating effect in rats. The physical characteris

The ontogeny of echolocation in a Yangtze finless porpoise (Neophocaena phocaenoides asiaeorientalis)

Acoustic and concurrent behavioral data from one neonatal male Yangtze finless porpoise (Neophocaena phocaenoides asiaeorientalis) in captivity were presented. The calf click train was first recorded at 22 days postnatal, and the frequency of hydrophone-exploration behavior with head scanning motions in conjunction with emissions of click trains by the calf increased gradually with age. The echolocation clicks in the first recorded click train were indistinguishable from those of adults. Calf echolocation trains were found to decrease in maximum click-repetition rate, duration, and number of clicks per train with age while the. minimum click-repetition rate remained more consistent. (c) 2007 Acoustical Society of America.

A method for individual identification of echolocation signals in free-ranging finless porpoises carrying data loggers

Echolocation click events of a free-ranging juvenile and an adult finless porpoise (Neophocaena phocaenoides) were recorded with an acoustic data logger. Additionally, dive depth and swim speed of the juvenile were recorded with a behavior data logger. Echoes of echolocation signals from the water surface were clearly detected in shallow dives approximately less than 2 m. The delay time between a surface echo and a direct signal corresponded with the two-way transmission time for the animal's depth, indicating that the signals originated from the animal wearing the data loggers. The finless porpoises produced echolocation signals frequently and were thought to be able to detect their depth by listening to echoes from the water surface. (C) 2000 Acoustical Society of America. [S0001-4966(00)01609-X].

Echolocation range of captive and free-ranging baiji (Lipotes vexillifer), finless porpoise (Neophocaena phocaenoides), and bottlenose dolphin (Tursiops truncatus)

The interclick intervals of captive dolphins are known to be longer than the two-way transit time between the dolphin and a target. In the present study, the interclick intervals of free-ranging baiji, finless porpoises, and bottlenose dolphins in the wild and in captivity were compared. The click intervals in open waters ranged up to 100-200 ms, whereas the click intervals in captivity were in the order of 4-28 ms. Echolocation of free-ranging dolphins appears to adapt to various distance in navigation or ranging, sometimes up to 140 m. Additionally, the difference of waveform characteristics of clicks between species was recognized in the frequency of maximum energy and the click duration. (C) 1998 Acoustical Society of America. [S0001-4966(98)06609-0].

QtUCP-A program for determining unit-cell parameters in electron diffraction experiments using double-tilt and rotation-tilt holders

A computer program, QtUCP, has been developed based on several well-established algorithms using GCC 4.0 and Qt (R) 4.0 (Open Source Edition) under Debian GNU/Linux 4.0r0. it can determine the unit-cell parameters from an electron diffraction tilt series obtained from both double-tilt and rotation-tilt holders. In this approach, two or more primitive cells of the reciprocal lattice are determined from experimental data, in the meantime, the measurement errors of the tilt angles are checked and minimized. Subsequently, the derived primitive cells are converted into the reduced form and then transformed into the reduced direct primitive cell. Finally all the patterns are indexed and the least-squares refinement is employed to obtain the optimized results of the lattice parameters. Finally, two examples are given to show the application of the program, one is based on the experiment, the other is from the simulation. (C) 2008 Elsevier B.V. All rights reserved.

集群网络评测模型的新探索

传统集群网络(cluster area network,简称cLAN)的评测模型主要考虑了延迟、带宽、路由、拥塞、网络拓扑结构等因素.但这些因素是否足以描述实际应用程序在集群上的通信行为,或者对其在集群系统上的性能给出一个很好的预测呢?当对NAS Parallel Benchmark(2.4版本)在集群系统深腾1800(DeepComp 1800)上进行大量测试时发现,集群网络的通信性能可以被一种特殊的通信模式(LU模式)所严重影响.更深入的研究表明,这个影响LU模式的因素是独立于前面所述的如延迟、带宽、路由、拥塞、网络拓扑结构等因素的.因此有必要对集群网络的评测模型重新进行审视,并增加一个新的性能评测因子以反映这个新发现的现象.从研究结果来看,这个重新审视也将对集群系统上的并行算法设计以及实际大规模科学计算的应用程序性能的优化提供一些新的思路.

面向高性能数值计算的并行计算模型DRAM(h)

提出了一个基于存储层次的新并行计算模型DRAM（h），并在该模型下对两个经典并行数值计算算法的不同实现形式：四种形式并行了三角方程求解（PTRS）和六种形式无列选主元并行LU分解（PLU），进行了分析。模型分析表明，具有近乎相同时间和空间复杂性的同一算法不同实现形式在该模型下会有完全不同的存储复杂度。作者在日立公司SR2201 MPP并行机、曙光3000超级服务器和中国科学院科学与工程计算国家重点实验室（LSEC）的128节点Linux Cluster等三种并行计算平台上对模型分析结果进行了实验验证。结果表明，该模型分析在绝大数情况下都能较好地与不同实验枰台上的实验结果吻合。个别出现偏差的分析结果，在根据计算平台的存储层次特点修改模型分析的假定后，也能够进行解释。这说明了该模型以不同形式的算法实现进行存储访问模式区分的有效性。对在计算模型中加入指令/线程级并行的可行性和方法的研究是下一步的工作。

FM—index算法性能测试及并行化

介绍了FM-index压缩查询技术，详细阐述了FM—index的工作流程，描述了实现计算字符串在压缩文本中出现次数的算法。对FM-index的源代码在Linux平台上进行了测试，从测试结果分析了使用FM-index进行压缩查询的优点和不足。最后给出了加快FM-index压缩速度的一个并行化算法的初步设计思路。

交换机和路由器一体化的设计与实现

宽带社区接入网是下一代网络研究的主要领域之一.RBISN(社区宽带综合业务网络)研究使用交换式以太网提供电视、IP电话和Internet接入服务,边缘路由设备必不可少.该文分析了该环境下的通信量,在对可用的方案进行对比的基础上,提出了将智能二层VLAN交换机和VLAN路由器一体化的方案.随后给出其模型和设计,加以实现以证明其可行性.

基于路由器编码的自适应包标记

拒绝服务攻击由于其高发性、大危害、难防范而成为因特网上的一大难题.研究人员为此提出了各种各样的对策,其中概率包标记具有较大的潜力.然而,现有的标记方案都存在各种各样的缺点.提出了一个新的标记方案,与其他标记方法相比,该方案具有反映灵敏,误报率低和计算量小的优点.此外,该方法还限制了攻击者伪造追踪信息的能力.

基于虚拟机架构的系统攻击与防范技术研究

随着虚拟机架构的日渐流行，虚拟机平台的安全性越来越重要。研究虚拟机平台下的系统攻击和防范技术，对于化解系统面临的安全威胁，保障系统的安全运行具有十分重要的意义。 本文以开源的虚拟机系统 Xen 为研究对象，分别研究了针对虚拟机监控器（VMM）和客户机的攻击与防范技术。 对于虚拟机监控器， 本文分析了一个利用DMA技术攻击VMM的恶意程序，并讨论了使用 IOMMU防范该类型攻击的方法。 对于客户机，本文分析了内核 Rootkit 的常见攻击技术，并给出了一个虚拟机架构下防范 Rootkit的方法。 该方法通过写保护来保证内核关键资源的完整性，并通过 Xen对页表的保护来确保写保护的有效性。在 2.6 版本的Linux上进行的实验表明，该方法能够有效防止多种Rootkit的攻击。

一种机载DSP系统主控机的实时计算模型

现代机载数字信号处理 (DSP)系统中的主控机是具有严格实时需求的计算环境 ,负责实时存储、显示和控制等重要功能 针对机载DSP系统的特殊性及其对实时计算的具体需求 ,提出了一种基于实时Linux技术的实时计算模型 它通过与操作系统层的实时支持相结合 ,实现了包括多任务并发的实时调度方法、硬实时和软实时任务协同工作机制以及实时事件驱动机制在内的完整运行环境 相对于现有的基于分时操作系统的方案 ,实时性能更为可靠 ,计算资源利用率高 ;相对于使用受严格许可证限制的商业实时操作系统的技术 ,应用开发灵活易行 ,软件成本更低