226 resultados para nitrocefin, HEK 293, HEK 293T, biopharmaceuticals


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本文通过自相关分析探讨在“Maunder极小期”期间太阳活动是否仍然存在11年活动周期.利用Eddy根据欧洲望远镜在“Maunder极小期”时观测的太阳黑子记录所作的相对黑子数年平均值进行了自相关分析,也与中国地方志在“Maunder极小期”时的有关黑子记录一起进行了同样的自相关分析.在作自相关分析时采用几种不同的方法进行比较,结果发现,11年活动周期性的存在与否与所选用的统计方法有关,因此不能绝对地说在“Maunder极小期”时太阳活动完全停止了,或者说在“Maunder极小期”时仍然存在着11年周期的活动性质.

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<正> 由于同位素分离日益增长的需要,提高单极分离系数和产量成为十分重要的问题.机械离心机可以使两种不同气体或液体高速旋转,达到使其分离的目的.但因结构强度限制和存在机械振动,继续提高分离系数有一定困难.能否使用电磁场力来推动两种同位素气体产生更高的转速,达到分离的目的呢?六十年代开始探索其可能性.Gross等人利

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从溶液中聚集体的角度研究了溶液的热历史改变生长出的蛋白质晶体的数目和尺寸的内在原因.将在281和309 K下保存1 d的两组溶菌酶溶液按不同比例混合,加入沉淀剂生长晶体.随着高温溶液的比例增加,生长出的晶体数目减少,同时溶液中生长基元的尺寸增大.在5周内,采用动态光散射对281,293和309K三种温度下保存的溶菌酶溶液中聚集体的变化情况进行监测,发现溶液中均存在大小不同的两部分聚集体,称之为小聚集体与多聚体.前者的尺寸基本不随保存时间而变化,而后者尺寸随保存时间增加而减小,减小的速度与保存温度有关.多聚体的尺寸经过5周后和小聚集体基本相同.研究结果表明,处于无序聚集阶段的溶液的均一化程度和成核阶段生长基元的尺寸受到了溶液热历史的影响,并最终对晶体的数目产生影响.

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Adiabatic shear localization is a mode of failure that occurs in dynamic loading. It is characterized by thermal softening occurring over a very narrow region of a material and is usually a precursor to ductile fracture and catastrophic failure. This reference source is the first detailed study of the mechanics and modes of adiabatic shear localization in solids, and provides a systematic description of a number of aspects of adiabatic shear banding. The inclusion of the appendices which provide a quick reference section and a comprehensive collection of thermomechanical data allows rapid access and understanding of the subject and its phenomena. The concepts and techniques described in this work can usefully be applied to solve a multitude of problems encountered by those investigating fracture and damage in materials, impact dynamics, metal working and other areas. This reference book has come about in response to the pressing demand of mechanical and metallurgical engineers for a high quality summary of the knowledge gained over the last twenty years. While fulfilling this requirement, the book is also of great interest to academics and researchers into materials performance.

Table of Contents

1Introduction1
1.1What is an Adiabatic Shear Band?1
1.2The Importance of Adiabatic Shear Bands6
1.3Where Adiabatic Shear Bands Occur10
1.4Historical Aspects of Shear Bands11
1.5Adiabatic Shear Bands and Fracture Maps14
1.6Scope of the Book20
2Characteristic Aspects of Adiabatic Shear Bands24
2.1General Features24
2.2Deformed Bands27
2.3Transformed Bands28
2.4Variables Relevant to Adiabatic Shear Banding35
2.5Adiabatic Shear Bands in Non-Metals44
3Fracture and Damage Related to Adiabatic Shear Bands54
3.1Adiabatic Shear Band Induced Fracture54
3.2Microscopic Damage in Adiabatic Shear Bands57
3.3Metallurgical Implications69
3.4Effects of Stress State73
4Testing Methods76
4.1General Requirements and Remarks76
4.2Dynamic Torsion Tests80
4.3Dynamic Compression Tests91
4.4Contained Cylinder Tests95
4.5Transient Measurements98
5Constitutive Equations104
5.1Effect of Strain Rate on Stress-Strain Behaviour104
5.2Strain-Rate History Effects110
5.3Effect of Temperature on Stress-Strain Behaviour114
5.4Constitutive Equations for Non-Metals124
6Occurrence of Adiabatic Shear Bands125
6.1Empirical Criteria125
6.2One-Dimensional Equations and Linear Instability Analysis134
6.3Localization Analysis140
6.4Experimental Verification146
7Formation and Evolution of Shear Bands155
7.1Post-Instability Phenomena156
7.2Scaling and Approximations162
7.3Wave Trapping and Viscous Dissipation167
7.4The Intermediate Stage and the Formation of Adiabatic Shear Bands171
7.5Late Stage Behaviour and Post-Mortem Morphology179
7.6Adiabatic Shear Bands in Multi-Dimensional Stress States187
8Numerical Studies of Adiabatic Shear Bands194
8.1Objects, Problems and Techniques Involved in Numerical Simulations194
8.2One-Dimensional Simulation of Adiabatic Shear Banding199
8.3Simulation with Adaptive Finite Element Methods213
8.4Adiabatic Shear Bands in the Plane Strain Stress State218
9Selected Topics in Impact Dynamics229
9.1Planar Impact230
9.2Fragmentation237
9.3Penetration244
9.4Erosion255
9.5Ignition of Explosives261
9.6Explosive Welding268
10Selected Topics in Metalworking273
10.1Classification of Processes273
10.2Upsetting276
10.3Metalcutting286
10.4Blanking293
 Appendices297
AQuick Reference298
BSpecific Heat and Thermal Conductivity301
CThermal Softening and Related Temperature Dependence312
DMaterials Showing Adiabatic Shear Bands335
ESpecification of Selected Materials Showing Adiabatic Shear Bands341
FConversion Factors357
 References358
 Author Index369
 Subject Index375

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Mitochondria dynamics is crucial to many biological processes such as mitochondria fusion and fission, which is highly correlated to the mechanics of single mitochondria. However, the mechanobiological coupling of mitochondria has been poorly understood. Here membrane deformability and membrane tension of individual mitochondria isolated from MtDsRed labeled human embryonic T-Rex-293 kidney cells were measured using a micropipette aspiration assay. The results demonstrated that membrane deformation of isolated mitochondria exhibited an elastic transition phase followed by an equilibrium phase, and mitochondrial membrane tension was proportional to the area compressibility. It was also indicated that mitochondrial membrane deformability was significantly affected by physical chemical factors such as osmotic pressure or pH value, and was further correlated to mitochondrial functionality in different respiratory states and Ca2+ regulation. These findings provide a new insight into understanding the mechanical regulation of mitochondrial physiology.

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Based on birefringence, a building-block stacking technique is suggested in this paper. A solid-state optical morphological processor module is thus developed, which is an integration of a beam array generator submodule, an optical connector submodule, and a Pockels readout optical modulator. It is shown that the technique is compact in construction, simple for fabrication, and insensitive to the environment.

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