35 resultados para STRUCTURE-BASED DRUG DESIGN


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设计实现了一个基于数字笔的用户界面设计工具,该工具以面向笔式界面领域,基于场景的设计思想来设计系统中的界面场景组织关系以及场景之间的动态切换方式,设计者与工具间的交互自然流畅、快捷高效。通过手势识别技术,该工具可以将场景的设计结果转换为内部的界面描述语言,并通过相应的解释最终构造生成笔式用户界面。该工具可以快速生成界面原型,从而有效地提高了笔式交互系统的设计和开发效率。

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Concept maps are an important tool to knowledge organization,representation, and sharing. Most current concept map tools do not provide full support for hand-drawn concept map creation and manipulation, largely due to the lack of methods to recognize hand-drawn concept maps. This paper proposes a structure recognition method. Our algorithm can extract node blocks and link blocks of a hand-drawn concept map by combining dynamic programming and graph partitioning and then build a concept-map structure by relating extracted nodes and links. We also introduce structure-based intelligent manipulation technique of hand-drawn concept maps. Evaluation shows that our method has high structure recognition accuracy in real time, and the intelligent manipulation technique is efficient and effective.

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为缩短的笔式用户界面软件的开发周期,让设计人员对软件的整体构思在开发过程中得以保持,提高团队人员的交流效率,提出了有关笔式界面软件的文档描述规范PUIML(pen-based user interface modeling language),并设计实现了一个笔交互的笔式用户界面软件设计工具。以笔式操作平台为软件平台,以PUIML为数据模型,采用基于场景设计的开发方法,为设计人员和用户提供自然的纸笔交互方式,设计结果形成PUIML形式的文档,通过主控程序执行。实践结果表明,使用PUI Maker可以解决笔式用户界面开发中存在的以开发人员为中心,原始设计与开发结果不一致等问题,提高了笔式界面软件的开发效率。

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基于属性的存取,对于在包含不同来源的大量文件的系统中进行有效的信息管理来说,是一种非常具有吸引力的特性。然而尽管在相当长的一段时间内其价值已广为人知,该特性的真正有实用价值的实现仍然非常之少。本文探讨了实现该特性时面临的主要挑战,以及它们是怎样在一种专为此目的设计的文件系统中,通过成功的应用各种原则而被妥善处理。

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We present a staggered buffer connection method that provides flexibility for buffer insertion while designing global signal networks using the tile-based FPGA design methodology. An exhaustive algorithm is used to analyze the trade-off between area and speed of the global signal networks for this staggered buffer insertion scheme, and the criterion for determining the design parameters is presented. The comparative analytic result shows that the methods in this paper are proven to be more efficient for FPGAs with a large array size.

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阐述应用程序开发的三层结构的基本组织形式及存在的问题,提出了基于四层结构的应用程序开发模型及其带来的好处.结合七里村采油厂综合信息系统开发实例,对基于.NET的四层结构的应用程序开发技术进行了研究,实现了基于.NET的四层结构的部署,阐述了基于四层结构的具体实现策略,并在此基础上给出了基于四层结构的应用程序设计与开发的关键技术.

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As the leading nanodevice candidate, single-walled carbon nano-tubes (SWNTs) have potential therapeutic applications in gene therapy and novel drug delivery. We found that SWNTs can inhibit DNA duplex association and selectively induce human telomeric i-motif DNA formation by binding to the 5'-end major groove under physiological conditions or even at pH 8.0. SWNT binding to telomeric DNA was studied by UV melting, NMR, S1 nuclease cleavage, CD, and competitive FRET methods. These results suggest that SWNTs might have the intriguing potential to modulate human telomeric DNA structures in vivo, like biologically relevant B-A and B-Z DNA transitions, which is of great interest for drug design and cancer therapy.

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在已有制造工艺及标定技术基础上,为进一步改善大型铰接并联六维测力平台的测量精度,本文基于螺旋理论和影响系数原理,引入符号函数建立了Stewart结构大型铰接六维测力平台的摩擦模型。文中提出了关节摩擦对铰接并联六维测力平台测量精度的影响矩阵及I、H类误差表达式,绘制了在不同外载和关节摩擦系数条件下,六维测力平台的I、II类误差曲线,并总结丁关节摩擦和平台自重对测力平台测量精度的影响规律。为具有普通球形铰链人型Stewart平台六维测力下台精度的提高和改善提供了理论基础。

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文中设计了模块化的新型蛇形机器人关节单元 .该单元具有三个自由度 ,其中摆动和俯仰自由度由耦合机构驱动来获得较大的力矩和活动空间 .由该单元组成的蛇形机器人具有很强的驱动能力 ,能够抬起较多的单元 .针对蛇形机器人的特点 ,给出了耦合机构的设计原则 .对蛇形机器人抬起方法作了分析 ,得出采用适当规划方法能够抬起的最大单元数量是直接抬起的最大单元数量的平方关系的结论 ,并在此基础上分析了最大关节角对机器人抬起的影响 ,最后结合实例验证了上面分析结果

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本文给出的结构基自由网格法综合了正规栅格法和自由空间法的基本思想,依环境的结构信息确定地解决自由空间分割过程中构造想象边界的任意性问题,由此消除了路径的不确定性;此外,结构基自由网格模型可以在一定程度上消除规划路径“绕大弯”的现象。

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In this paper, we propose an n-type vertical transition bound-to-continuum Ge/SiGe quantum cascade structure utilizing electronic quantum wells in the L and Gamma valleys of the Ge layers. The optical transition levels are located in the quantum wells in the L valley. The Gamma-L intervalley scattering is used to depopulate the lower level and inject the electrons into the upper level. We also show that high quality Si1-yGey pseudosubstrate is obtained by thermal annealing of Si1-xGex/Ge/Si structure. (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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We present designs of high-efficiency compression grating based on total internal reflection (TIR) for picosecond pulse laser at 1053 nm. The setup is devised by directly etching gratings into the bottom side of a prism so that light can successfully enter (or exit) the compression grating. Dependence of the -1 order diffraction efficiencies on the constructive parameters is analyzed for TE- and TM-polarized incident light at Littrow angle by using Fourier modal method in order to obtain optimal grating structure. The electric field enhancement within the high-efficiency TIR gratings is regarded as another criterion to optimize the structure of the TIR gratings. With the criterion of high diffraction efficiency, low electric field enhancement and sufficient manufacturing latitude, TIR compression gratings with optimized constructive parameters are obtained for TE- and TM-polarized incident light, respectively. The grating for TE-polarized light exhibits diffraction efficiencies higher than 0.95 within 23 nm bandwidth and relatively low square of electric field enhancement ratio of 5.7. Regardless of the internal electric field enhancement, the grating for TM-polarized light provides diffraction efficiencies higher than 0.95 within 42 nm bandwidth. With compact structure, such TIR compression gratings made solely of fused silica should be of great interest for application to chirped pulse amplification (CPA) systems. (c) 2007 Elsevier B.V. All rights reserved.

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AlGaN-based resonant-cavity-enhanced (RCE) p-i-n photodetectors (PDs) for operating at the wavelength of 330 nm were designed and fabricated. A 20.5-pair AlN/Al0.3Ga0.7N distributed Bragg reflector (DBR) was used as the back mirror and a 3-pair AlN/Al0.3Ga0.7N DBR as the front one. In the cavity is a p-GaN/i-GaN/n-Al0.3Ga0.7N structure. The optical absorption of the RCE PD structure is at most 59.8% deduced from reflectance measurement. Selectively enhanced by the cavity effect, a response peak of 0.128 A/W at 330 nm with a half-peak breadth of 5.5 nm was obtained under zero bias. The peak wavelength shifted 15 nm with the incident angle of light increasing from 0 degrees to 60 degrees.