39 resultados para Adiponectine récepteurs 1 et 2
Resumo:
Microstructure and mechanical properties of Mg-4.5Zn-xNd (x = 0, 1 and 2, wt%) alloys heat-treated at 603 K for 2 It have been investigated. T-phase (an Mg-Zn-Nd ternary phase) was observed in the Nd containing alloys. The optimal mechanical properties were obtained in the Mg-4.5Zn-1Nd alloy, and the ultimate tensile strength and yield strength were 228 and 79 MPa, respectively. Through comparing with the Mg-4.5Zn alloy, the increments of ultimate tensile strength and yield strength were 51 and 17 MPa.
Resumo:
The first aryldiimine NCN-pincer ligated rare earth metal dichlorides (2,6-(2,6-C6H3R2N=CH)(2)C6H3)LnCl(2)(THF)(2) (Ln = Y, R = Me (1), Et (2), Pr (3); R = Et, Ln = La (4), Nd (5), Gd (6), Sm (7), Eu (8), Tb (9), Dy (10), Ho (11), Yb (12), Lu (13)) were successfully synthesized via transmetalation between 2,6-(2,6-C2H3-R2N=CH)(2)-C6H3Li and LnCl(3)(THF)(1 similar to 3.5). These complexes are isostructural monomers with two coordinating THF molecules, where the pincer ligand coordinates to the central metal ion in a kappa C:kappa N: kappa N' tridentate mode, adopting a meridional geometry.
Resumo:
A series of new 1,1'-bi-2-naphthol (BINOL) derived ligands, 3-[6-(hydroxymethyl)pyridin-2-yl]-BINOLs or 3,3'-bis[6(hydroxymethyl)pyridin-2-yl]-BINOLs, bearing one or two chiral pyridinylmetlianols attached to a binaphthyl skeleton, have been synthesized using the Suzuki cross-coupling reaction. The resulting compounds have been used as ligands in the enantioselective addition of diethylzinc to aldehydes; the products were obtained with up to 96% ee.
Resumo:
The crystal structures of EtEDTB.1.4C(2)H(5)OH.5H(2)O 1 and H4EtEDTB(ClO4)(4).C2H5OH 2 (EtEDTB = N, N,N',N'-tetrakis[2-(1-ethylbenzimidazolyl)methyl]-1,2-ethanediamine) have been determined by single-crystal X-ray diffraction method. Compound 1 crystallizes in the space group P(1) over bar with a = 11.489(2), b = 11.866(3), c = 12.002(3) Angstrom, alpha = 97.47(2), beta = 114.564(13), gamma = 114.11(2)degrees, V = 1266.6(5) Angstrom(3), Z = 1, M-r = 847.48, D-c = 1.111 g/cm(3), F(000) = 456 and mu(MoKalpha) = 0.076 mm(-1). A total of 5207 reflections were measured for 1, of which 4323 were independent. The structure of 1 was solved by direct methods and refined by full-matrix least-squares technique to the final R = 0.0706 and wR = 0.1802 for 1318 observed reflections with I > 2sigma(I). In the structure of 1, centrosymmetric EtEDTB molecules are linked by hydrogen bonds through water and ethanol to form 2-dimensional network. Compound 2 crystallizes in the space group C2/c with a = 24.260(5), b = 13.040(3), c = 17.680(4) Angstrom, beta = 97.50(3)degrees, V = 5545.2(2) Angstrom(3), Z = 4, M-r = 1140.80, D-c = 1.366 g/cm(3), F(000) = 2384 and mu(MoKalpha) = 0.289 mm(-1).
Resumo:
利用差示扫描量热仪、X射线衍射仪、正交偏光显微镜研究了成核剂 1,3 :2 ,4-二 (亚苄基 ) -D山梨醇(DBS)对聚对苯二甲酸乙二醇酯 (PET) /聚 2 ,6-萘二甲酸乙二醇酯 (PEN)共混体系的结构及结晶形态的影响。结果表明 :成核剂的加入 ,使PET/PEN共混体系熔融起始温度升高 10℃左右 ,结晶峰形变尖锐 ,说明加入成核剂后有效促进了PET/PEN共混体系的结晶。实验结果表明 :成核剂含量低于 1%时 ,PET/PEN共混体系晶体的球晶完整。成核剂含量大于 3 %时 ,PET/PEN /DBS共混体系晶体的球晶碎小。成核剂的加入 ,能够有效地减小球晶尺寸和降低球晶的完善性
Resumo:
在合成BCPDA基础上 ,对甲胎蛋白抗体与BCPDA连接及与铕离子螯合条件进行了研究。BCPDA与甲胎蛋白抗体反应后 ,分离纯化最佳淋洗液为pH9.1的0.1mol/L碳酸盐缓冲溶液 ,BCPDA用量为甲胎蛋白抗体量 (mol)的120~160倍;反应时间为30min。讨论了Eu3+ BCPDA AFP抗体螯合物的荧光光谱 ,最佳温育时间为60min,体系pH值为7.8的Tris HCl溶液。当Eu3+ 浓度为10-6mol/L时,BCPDA的检出限为4.3×10-11mol/L。
Resumo:
Full Paper: Two new 1,1'-binaphthyl-2,2'-diyl-based dianhydrides, i.e., 2,2'-bis(3,4-dicarboxybenzamido)-1,1'-binaphthyl dianhydride (BNDADA) and 2,2'-bis(3,4-dicarboxybenzoyloxy)-1,1'-binaphthyl dianhydride (BNDEDA), were synthesized and polymerized with various aromatic diamines to afford polyimides through the traditional two-step method. The polyimides with inherent viscosities ranging from 0.27 to 0.70 dl . g(-1) showed excellent solubilities in polar solvents such as DMAc, DMSO and NMP etc., except of the poly(ester imide) prepared from BNDEDA and benzidine. Poly(ester imide)s based on BNDEDA can also be readily dissolved in weakly polar solvents such as THF, CH2Cl2 and CHCl3. The glass transition temperatures of these polyimides are in the range of 210-310 degrees C; the 5% weight loss temperatures are in the range of 390-465 degrees C in nitrogen and 384-447 degrees c in air. These polymers from light yellow, tough films that were transparent above 365 nm. The effects of different flexible units attached in the 2- and 2'-positions, i.e., amide, ester and ether, on the properties of the polyimides obtained are discussed.
Resumo:
A series of new optically active aromatic polyimides containing axially dissymmetric 1,1'-binaphthalene-2,2-diyl units were prepared from optically pure (R)-(+)-or (S)-(-)-2,2'-bis(3,4-dicarboxyphenoxy)-1,1'-binaphthalene dianhydrides and various aromatic diamines via a conventional two-step procedure that included ring-opening polycondensation and chemical cyclodehydration. The optically pure isomer of dianhydride was prepared by a nucleophilic substitution of optically pure (R)-(+)or (S)-(-)1,1'-bi-2-naphthol with 4-nitrophthalonitrile in aprotic polar solvent and subsequent hydrolysis of the resultant tetranitrile derivatives, followed by the dehydration of the corresponding tetracarboxylic acids to obtain the dianhydrides. These polymers were readily soluble in common organic solvents such as N,N-dimethylacetamide, N-methyl-2-pyrrolidone, and m-cresol, etc., and have glass transition temperatures of 251-296 degrees C, and 5% weight loss occurs not lower than 480 degrees C. The specific rotations of the optically active polyimides ranged from +196 degrees to +263 degrees, and the optical stability and chiroptical properties of them were also studied. (C) 1997 John Wiley & Sons, Inc.
Resumo:
2,2'-Bis(3,4-dicarboxyphenoxy)-1,1'-binaphthyl dianhydride was used as a new monomer with various aromatic diamines to obtain polyimides by the usual two-step method. The bis(ether anhydride) was prepared by a nucleophilic substitution of I,1'-bi-2-naphthol with N-phenyl-4-chlorophthalimide, N-methyl-4-nitrophthalimide or 4-nitrophthalonitrile in aprotic polar solvent, and subsequent hydrolysis of the resulting bis(ether imide)s or bis(ether dinitrile), and then dehydration of the corresponding tetracarboxylic acid to afford the dianhydride. Most of the obtained polyimides were soluble in chloroform, pyridine, DMF, etc. The polyimide prepared from p-phenylene diamine was partial crystalline, whereas the others showed amorphous patterns in a WAXD study. These polymers have glass transition temperatures between 255-294 degrees C and 5% weight loss temperatures in the range of 502-541 degrees C in nitrogen and 473-537 degrees C in air. (C) 1997 Elsevier Science Ltd.
Resumo:
以1,4-萘醌为原料,经溴化、氰化、烷基化合成了1,4-二丙氧基-2,3-二氰基萘,用SiemensP4四圆衍射仪测得了晶体结构。合成方法简便,反应时间短,产率高。
Resumo:
用 Siemens P4四圆衍射仪,测得了1,4-二丙氧基-2,3-二氰基萘的晶体结构。晶体属单斜晶系,空间群为 C2/C。晶格参数 a=14.987(3)A,b=10.527(2),c=11.755(2),β=118.98°(3),晶胞体积 V=1622.4(6)3,Z=4,Dc=1.205Kg/m~3,μ(MoK_α)=0.079mm~(-1),F(000)=624,T=293(2)K_o晶体结构应用直接法,解出最后的偏离因子 R=0.0554[1425个Ⅰ≥2σ(Ⅰ)衍射点]。结构分析表明,萘环的1,4和2,3位碳原子上的氢原子分别被丙氧基和氰基所取代,由于取代基的引入使萘环的结构有所改变。
Resumo:
本文报道9种新的含磷杂环化合物的电子轰击质谱(EIMS),并应用B/E、B2/E联动扫描及精确质量测量技术,探讨了该类化合物的质谱断裂机理,发现骨架重排及开环反应是该类化合物主要的质谱特征,而R2基因对重排过程有很大影响。
Resumo:
应用EI质谱和联动扫描技术研究了13个有机磷杂环化合物,讨论了主要离子的形成过程,分子离子在EI条件下的各种重排反应和取代基对不同解离反应产物离子相对强度的影响。
Resumo:
The mass spectral behaviour of 15 new type of organic phosphorus compounds with a considerable insecticidal activity, 1, 3,2-oxazaphospholidine 2-sulfides derivatives, under 70 eV electron impact has been studied by means of high and low resolution mass spectrometry as well as by B/E linked scan and MIKES/CID analysis. Discussion is focused into the isomerization between oxygen and sulphur in molecules and some rearrangement reactions.