Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65.

豌豆核酮糖1,5-二磷酸羧化酶/加氧酶亚基结合蛋白的纯化及特性

用~(35)S-Met在照光下与豌豆完整叶绿体保温,显示新合成的标记的RubisCO大亚基与结合蛋白形成一复合物,经ATP处理后解离为结合蛋白亚基,同时释放出的标记的RubisCO大亚基参与了RubisCO的装配。豌豆叶片提取液经热处理,硫酸铵分部,DEAE-Sepharose fast flow和Sephacryl S-300柱层析在ND-PAGE,SDS-PAGE上显示为一条带,估计纯度达90％以上,得率比以前报道的高12倍。纯化的结合蛋白表面巯基数经测定为12±1个,总巯基数为36±1个。远紫外CD

Chromosomal localization and molecular marker development of the lipopolysaccharide and beta-1,3-glucan binding protein gene in the Zhikong scallop Chlamys farreri (Jones et Preston) (Pectinoida, Pectinidae)

Zhikong scallop Chlamys farreri(Jones et Preston) is an economically important species in China. Understanding its immune system would be of great help in controlling diseases. In the present study, an important immunity-related gene, the Lipopolysaccharide and Beta-1,3-glucan Binding Protein (LGBP) gene, was located on C. farreri chromosomes by mapping several lgbp-containing BAC clones through fluorescence in situ hybridization (FISH). Through the localization of various BAC clones, it was shown that only one locus of this gene existed in the genome of C. farreri, and that this was located on the long arm of a pair of homologous chromosomes. Molecular markers, consisting of eight single nucleotide polymorphism (SNPs) markers and one insertion-deletion (indel), were developed from the LGBP gene. Indel marker testing in an F1 family revealed slightly distorted segregation (p = 0.0472). These markers can be used to map the LGBP gene to the linkage map and assign the linkage group to the corresponding chromosome. Segregation distortion of the indel marker indicated genes with deleterious alleles might exist in the surrounding region of the LGBP gene.

SRNS方程求解叶栅流动的研究

对不可压SRNS方程提出了拟压缩性空间推进法，对压气机叶栅和透平叶栅的典型计算表明，该法可准确而快速地模拟叶轮机械内部流场。

铸件残余应力的爆炸法消除

将铸件浸在水中，在水中距铸件适当位置放置炸药并引爆，铸件在爆炸引起的冲击载荷作用下，其残余应力的４０％左右得以消除。该法具有生产成本低、污染小的优点

小钝头锥无粘平衡、非平衡绕流流场的数值分析

本文给出钝头细长锥无粘、平衡和非平衡高超声速绕流流场的数值分析。对存在化学反应的空气,考虑了13种气体组分和22个化学反应,包括N_2、O_2和NO的振动松弛与离介过程之间的耦合反应。头部亚-跨声速区和后身高超声速区分别用直线法和有限差分法进行计算。在来流条件M_∞=20～26,Re_∞=(p_∞u_∞α)/μ_∞=1.5×10~3～5.5×10~6(α为头部半径)的参数范围内,给出了绕流流场和等离子体鞘层诸特性,如激波形状、电子密度和电子碰撞频率等。

二维扫描法测量连续型激光器远场分布

二维扫描法测量连续型激光器远场分布的原理是,用一个有一系列螺旋状分布小孔的旋转圆筒扫过被测光斑,以一维的旋转动作完成二维扫描。它能在10~(-3)—10~4瓦的功率范围内以10帧/秒的速度连续记录激光器二维的远场分布。此方法原则上适用于各种波长的连续输出激光器,特别适合于输出功率高、远场分布不规则并且随时间变化较快的连续激光器。

重力埧抗震問題研究(一)

<正> 在地震区内修建巨型水电站时,必須对水电站的主要結构物——拦河煩进行抗震問題的研究。 通过模型試驗,计算了重力坝茌地震作有下的振动、应力及位移。假設地震时,地基是作为整体来运动的,并且只考虑了地震时地面的水平运动、略去了地面的垂直运动的影响。选用美国1940年5月18日在El Centro(加利福尼亚州)的地震加速度記录(最大加速度为0.33g),和一系列的地震振谱作为地震的原始资料。

气/液界面上Richtmyer-Meshkov不稳定性的实验研究

报道了在国内首次实现的矩形激波管内气/液界面上(即Atwood number,A1)的Richtmyer-Meshkov(RM)不稳定性现象.实验在一台垂直矩形激波管中进行,得到了较低马赫数(M=1.36和1.58)下,多元扰动R-M不稳定性后期阶段气泡和尖钉高度对时间的增长规律,即气泡高度h_b ~ t~(0.55±0.01)1 ,尖钉高度h_s~ t.当激波马赫数从1.36增加到1.58时,气泡和尖钉高度对时间的指数规律没有发生明显改变,气泡的增长速度没有受到影响,而尖钉增长速度却有大幅度的增加.同时还观察研究了多元扰动R-M不稳定性中典型的气泡竞争现象.