Fluid flow induced calcium response in bone cell network

In our previous work, bone cell networks with controlled spacing and functional intercellular gap junctions had been successfully established by using microcontact printing and self assembled monolayers technologies [Guo, X. E., E. Takai, X. Jiang, Q. Xu, G. M. Whitesides, J. T. Yardley, C. T. Hung, E. M. Chow, T. Hantschel, and K. D. Costa. Mol. Cell. Biomech. 3:95-107, 2006]. The present study investigated the calcium response and the underlying signaling pathways in patterned bone cell networks exposed to a steady fluid flow. The glass slides with cell networks were separated into eight groups for treatment with specific pharmacological agents that inhibit pathways significant in bone cell calcium signaling. The calcium transients of the network were recorded and quantitatively evaluated with a set of network parameters. The results showed that 18 alpha-GA (gap junction blocker), suramin (ATP inhibitor), and thapsigargin (depleting intracellular calcium stores) significantly reduced the occurrence of multiple calcium peaks, which were visually obvious in the untreated group. The number of responsive peaks also decreased slightly yet significantly when either the COX-2/PGE(2) or the NOS/nitric oxide pathway was disrupted. Different from all other groups, cells treated with 18 alpha-GA maintained a high concentration of intracellular calcium following the first peak. In the absence of calcium in the culture medium, the intracellular calcium concentration decreased slowly with fluid flow without any calcium transients observed. These findings have identified important factors in the flow mediated calcium signaling of bone cells within a patterned network.

1994-2006年《水土保持研究》载文被引定量分析

利用中国知识资源总库的中国引文数据库检索《水土保持研究》在1994-2006年所载论文的被引用情况,采用文献计量学方法对该刊1994-2006年载文被《中国期刊文献引证数据库》来源期刊引用的情况进行统计分析及评价。从文献引证的角度透视《水土保持研究》的学术水平。该刊1994-2006年共载文2098篇,被引用2018篇,占载文总数的96.62%。2001-2006年该刊影响因子、即年指标等文献计量指标逐年上升,分析表明:《水土保持研究》载文质量较高,在该学科有较大的学术影响力。

陕西省汉台区1978年至2006年耕地数量变化及驱动力分析

汉台区是陕西省农业产业结构调整典型示范区,近年来,由于农业产业结构调整、退耕还林还草和建设占用耕地,汉台区耕地数量大量减少,耕地供需矛盾突出。本文利用1978年以来汉台区耕地长序列统计资料和近9年的土地详查与变更数据,研究汉台区土地利用现状及其结构变化、分析汉台区耕地数量变化的基本过程及空间差异、探讨耕地数量变化的主要驱动力。研究结果表明:①1978年～2006年全区耕地共减少5600hm2,平均每年减少200hm2,人均耕地减少0.027hm2,耕地递减率曲线与人均耕地递减率曲线走势基本一致;②建设占用耕地、退耕还林还草和农业结构调整等直接影响因子在4种类型区影响耕地变化差异明显;总体上,农业产业结构调整是全区耕地减少的主导因素,经济发展较快的城镇,建设占用耕地较多;③耕地面积与社会经济发展各因素间的相关系数约低于累计耕地面积与各因素之间的相关系数,说明全区耕地减少与社会经济发展存在时间上的错位性,即经济和社会发展滞后于对耕地资源的占用。

HIRFL-CSR commissioning in 2006 and 2007

HIRFL-CSR, a new heavy ion cooler-storage-ring system at IMP, had been in commissioning since the beginning of 2006. In the two years of 2006 and 2007 the CSR commissioning was finished, including the stripping injection (STI), electron-cooling with hollow electron beam, C-beam stacking with the combination of STI and e-cooling, the wide energy-range synchrotron ramping from 7 MeV/u to 1000 MeV/u by changing the RF harmonic-number at mid-energy, the multiple multi-turn injection (MMI), the beam accumulation with MMI and e-cooling for heavy-ion beams of Ar, Kr and Xe, the fast extraction from CSRm and single-turn injection to CSRe, beam stacking in CSRe and the RIBs mass-spectrometer test with the isochronous mode in CSRe by using the time-of-flight method.

Synchronism of Holocene East Asian monsoon variations and North Atlantic drift-ice tracers (vol 65；pg 443；2006)

IEECAS SKLLQG

2006年3月11日南京“泥雨”降尘特征及其粉尘来源

对２００６年春季南京地区一次“泥雨”形式的湿降尘特征进行了系统分析，并在此基础上对泥雨粉尘来源及泥雨降尘形成机制进行了探讨.