1 resultado para wild animals
em Cambridge University Engineering Department Publications Database
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Repository Napier (1)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberystwyth University Repository - Reino Unido (4)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- Aquatic Commons (53)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (29)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (8)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (15)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (2)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (34)
- Brock University, Canada (10)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (29)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (65)
- Cochin University of Science & Technology (CUSAT), India (6)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Deakin Research Online - Australia (14)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (6)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (45)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (56)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (19)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (27)
- Infoteca EMBRAPA (1)
- Instituto Politécnico de Viseu (3)
- Ministerio de Cultura, Spain (56)
- National Center for Biotechnology Information - NCBI (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (37)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (5)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (124)
- Queensland University of Technology - ePrints Archive (72)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Santarém - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal de Goiás - UFG (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (119)
- Research Open Access Repository of the University of East London. (2)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- South Carolina State Documents Depository (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (1)
- Universidade Complutense de Madrid (5)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (5)
- Universidade Federal do Rio Grande do Norte (UFRN) (4)
- Universita di Parma (2)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (6)
- Université de Lausanne, Switzerland (19)
- Université de Montréal, Canada (16)
- University of Michigan (12)
- University of Queensland eSpace - Australia (4)
- University of Southampton, United Kingdom (2)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a delicate compromise between sufficient colonization-mediated adaptive immunity and minimizing the risk for infection by the vaccine strain itself. Immune defects can predispose to vaccine strain infections. It has remained unclear whether vaccine safety could be improved via mutations attenuating a vaccine in immune-deficient individuals without compromising the vaccine's performance in the normal host. We have addressed this hypothesis using a mouse model for Salmonella diarrhea and a live attenuated Salmonella Typhimurium strain (ssaV). Vaccination with this strain elicited protective immunity in wild type mice, but a fatal systemic infection in immune-deficient cybb-/-nos2-/- animals lacking NADPH oxidase and inducible NO synthase. In cybb-/-nos2-/- mice, we analyzed the attenuation of 35 ssaV strains carrying one additional mutation each. One strain, Z234 (ssaV SL1344_3093), was >1000-fold attenuated in cybb-/-nos2-/- mice and ≈100 fold attenuated in tnfr1-/- animals. However, in wt mice, Z234 was as efficient as ssaV with respect to host colonization and the elicitation of a protective, O-antigen specific mucosal secretory IgA (sIgA) response. These data suggest that it is possible to engineer live attenuated vaccines which are specifically attenuated in immuno-compromised hosts. This might help to improve vaccine safety. © 2012 Periaswamy et al.