Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants.

Salmonella enterica causes a range of life-threatening diseases in humans and animals worldwide. Current treatments for S. enterica infections are not sufficiently effective, and there is a need to develop new vaccines and therapeutics. An understanding of how S. enterica spreads in tissues has very important implications for targeting bacteria with vaccine-induced immune responses and antimicrobial drugs. Development of new control strategies would benefit from a more sophisticated evaluation of bacterial location, spatiotemporal patterns of spread and distribution in the tissues, and sites of microbial persistence. We review here recent studies of S. enterica serovar Typhimurium (S. Typhimurium) infections in mice, an established model of systemic typhoid fever in humans, which suggest that continuous bacterial spread to new infection foci and host phagocytes is an essential trait in the virulence of S. enterica during systemic infections. We further highlight how infections within host tissues are truly heterogeneous processes despite the fact that they are caused by the expansion of a genetically homogeneous microbial population. We conclude by discussing how understanding the within-host quantitative, spatial and temporal dynamics of S. enterica infections might aid the development of novel targeted preventative measures and drug regimens.

Grand Challenges for Data Sensing and Analysis

A diverse group of experts proposed the 9 grand challenges outlined in this booklet. This expert task force was assembled by the ASCE TCCIT Data Sensing and Analysis (DSA) Committee and endorsed by the TRB AFH10(1) Construction IT joint subcommittee at the request of their membership. The task force did not rank the challenges selected, nor did it endorse particular approaches to meeting them. Rather than attempt to include every important goal for data sensing and analysis, the panel chose opportunities that were both achievable and sustainable to help people and the planet thrive. The panel’s conclusions were reviewed by several subject-matter experts. The DSA is offering an opportunity to comment on the challenges by contacting the task force chair via email at becerik@usc.edu.